5-HT(2a/2c) receptor agonist-induced increase in urinary isatin excretion in rats Reversal by both diazepam and dexamethasone

Biochemical Pharmacology

Volumn 58, Issue 8, 1999, Pages 1329-1334

  Tozawa, Yumiko ^a   Ueki, Akira ^b   Shimosawa, Tatsuo ^a   Fujita, Toshiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

5 HT(2A 2C) receptor; Anxiety; Corticotropin releasing factor; Dexamethasone; Isatin; m CPP

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXYLIC ACID 2 HYDROXY 1 METHYLPROPYL ESTER; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; ISATIN; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; CATECHOLAMINE SYNTHESIS; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS; URINALYSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DEXAMETHASONE; DIAZEPAM; DRUG ANTAGONISM; ISATIN; MALE; PIPERAZINES; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; STRESS;

EID: 0032818980     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00195-1     Document Type: Article

References (30)

1. Glover V., Bhattacharya S.K., Sandler M. Isatin - a new biological factor. Indian J Exp Biol. 29:1991;1-5.
2. Medvedev A.E., Clow A., Sandler M., Glover V. Isatin A link between natriuretic peptides and monoamines? Biochem Pharmacol. 52:1996;385-391.
3. Glover V., Halket J.M., Watkins P.J., Clow A., Goodwin B.L., Sandler M. Isatin Identity with the purified endogenous monoamine oxidase inhibitor tribulin . J Neurochem. 51:1988;656-659.
4. Watkins P., Clow A., Glover V., Halket J., Przyborowska A., Sandler M. Isatin, regional distribution in rat brain and tissues. Neurochem Int. 17:1990;321-333.
5. Bhattacharya S.K., Clow A., Przyborowska A., Halket J., Glover V., Sandler M. Effect of aromatic acids, pentylenetetrazole and yohimbine on isatin and tribulin activity in rat brain. Neurosci Lett. 132:1991;44-46.
6. Tozawa Y., Ueki A., Manabe S., Matsushima K. Stress-induced increase in urinary isatin excretion in rats. Reversal by both dexamethasone and α-methyl-p-tyrosine. Biochem Pharmacol. 56:1998;1041-1046.
7. 2 receptor. EMBO J. 7:1988;H35-H40.
8. Mueller E.A., Murphy D.L., Sunderland T. Neuroendocrine effects of m-chlorophenylpiperazine, a serotonergic agonist, in humans. J Clin Endocrinol Metab. 61:1985;1179-1184.
9. Charney D.S., Woods S.W., Goodman W.K., Heninger G.R. Serotonin function in anxiety. II. Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects. Psychopharmacology. 92:1987;14-24.
10. Kahn R.S., Asnis G.M., Wetzler S., von Praag H.M. Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder. Psychopharmacology. 96:1988;360-364.
11. Klein E., Zoher J., Geraci M.F., Murphy D.L., Uhde T.W. Anxiogenic effects of m-CPP in patients with panic disorder Comparison to caffeine's anxiogenic effects . Biol Psychiatry. 30:1991;973-984.
12. Germine M., Goddard A.W., Woods S.W., Charney D.S., Heninger G.R. Anger and anxiety responses to m-chlorophenylpiperazine in generalized anxiety disorder. Biol Psychiatry. 32:1992;457-461.
13. 1C receptor antagonists. Eur J Pharmacol. 164:1989;445-454.
14. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., Humphrey P.P. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev. 46:1994;157-203.
15. Calogero A.E., Bernardini R., Margioris A.N., Bagdy G., Gallucci W.T., Munson P.J., Jamarkin L., Tomai T.P., Brady L., Gold P.W., Chrousos G.P. Effects of serotonergic agonists and antagonists on corticotropin releasing hormone secretion by explanted rat hypothalami. Peptides. 10:1989;189-200.
16. Calogero A.E., Bagdy G., Szemeredi K., Tartaglia M.E., Gold P.W., Chrousos G.P. Mechanisms of serotonin receptor agonist-induced activation of the hypothalamic-pituitary-adrenal axis in the rat. Endocrinology. 126:1990;1888-1894.
17. 1C receptors. Neurosci Behav Rev. 16:1992;95-105.
18. Morley J.E., Farr S.A., Flood J.F. Isatin inhibits food intake in mice. Eur J Pharmacol. 305:1996;23-29.
19. Sandler M., Clow A., Watkins P.J., Glover V. Tribulin - an endocoid marker for anxiety in man. Stress Med. 4:1988;215-219.
20. Clow A., Glover V., Sandler M., Tiller J. Increased urinary tribulin output in generalized anxiety disorder. Psychopharmacology. 95:1988;378-380.
21. Sandler M., Przyborowska A., Halket J., Watkins P., Glover V., Coates M.E. Urinary but not brain isatin levels are reduced in germ-free rats. J Neurochem. 57:1991;1074-1075.
22. Bhattacharya S.K., Acharya S.B. Further investigations on the anxiogenic action of isatin. Biogen Amines. 9:1993;453-463.
23. Manabe S, Gao Q, Yuan J, Takahashi T and Ueki A, Determination of isatin in urine and plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 691: 197-202, 997.
24. Rivier C.L., Plotsky P.M. Mediation by corticotropin releasing factor (CRF) of adenohypophysial hormone secretion. Annu Rev Physiol. 48:1986;475-494.
25. Sutton R.E., Koof G.F., LeMoal M., Rivier J., Vale W. Corticotropin-releasing factor produces behavioral activation in rats. Nature. 297:1982;331-333.
26. Fisher L.A., Brown M.R. Central regulation of stress responses Regulation of the autonomic nervous system and visceral function by corticotrophin releasing factor-41 . Baillieres Clin Endocrinol Metab. 5:1991;35-50.
27. Suda T., Yajima F., Tomori N., Demura H., Shizume K. In vitro study of immunoreactive corticotropin-releasing factor release from the rat hypothalamus. Life Sci. 37:1985;1499-1505.
28. Imaki T., Nahan J.L., River C., Sawchenko P.E., Vale W. Differential regulation of corticotropin-releasing factor mRNA in rat brain regions by glucocorticoids and stress. J Neurosci. 11:1991;585-599.
29. Jensen J.B., Egsgaard H., Onckelen H.V., Jochimsen B.U. Catabolism of indole-3-acetic acid and 4- and 5-chloroindole-3-acetic acid in Bradyrhizobium japonicum. J Bacteriol. 177:1995;5762-5766.
30. Christen S., Peterhans E., Stocker R. Antioxidant activities of some tryptophan metabolites Possible implication for inflammatory diseases . Proc Natl Acad Sci USA. 87:1990;2506-2510.