The spinal 5-HT system contributes to the generation of fictive locomotion in lamprey

Brain Research

Volumn 879, Issue 1-2, 2000, Pages 188-192

  Zhang, W ^a,b   Grillner, S ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Lamprey; Locomotion; NMDA; Serotonin; Spiperone

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SEROTONIN 1A RECEPTOR; SPIPERONE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; INTERNEURON; LAMPREY; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; SPINAL CORD;

ANIMALS; GLUTAMIC ACID; LAMPREYS; LOCOMOTION; MOTOR ACTIVITY; N-METHYLASPARTATE; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN; SEROTONIN ANTAGONISTS; SPINAL CORD; SPIPERONE;

EID: 0034613335     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02747-5     Document Type: Article

References (20)

1. Alford S., Grillner S. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 506:1990;297-302.
2. Barbeau H., Rossignol S. The effects of serotonergic drugs on the locomotor pattern and on cutaneous reflexes of the adult chronic spinal cat. Brain Res. 514:1990;55-67.
3. Brodin L., Grillner S. The role of putative excitatory amino acid neurotransmitters in the initiation of locomotion in the lamprey spinal cord. II. The effects of amino acid uptake inhibitors. Brain Res. 360:1985;149-158.
4. Brodin L., Grillner S., Rovainen C.M. N-Methyl-D-aspartate (NMDA), kainate and quisqualate receptors and the generation of fictive locomotion in the lamprey spinal cord. Brain Res. 325:1985;302-306.
5. Buchanan J.T., Grillner S. 5-Hydroxytryptamine depresses reticulospinal excitatory postsynaptic potentials in motorneurons of the lamprey. Neurosci. Lett. 112:1991;71-74.
6. Christenson J., Cullheim S., Grillner S., Hökfelt T. 5-Hydroxytryptamine immunoreactive varicosities in the lamprey spinal cord have no synaptic specializations - an ultrastructural study. Brain Res. 512:1990;201-209.
7. Cohen A.H., Wallén P. The neuronal correlate of locomotion in fish. 'Fictive swimming' induced in an in vitro preparation of the lamprey spinal cord. Exp. Brain Res. 41:1980;11-18.
8. Dale N. Excitatory synaptic drive for swimming mediated by amino acid receptors in the lamprey. J. Neurosci. 6:1986;2662-2675.
9. Dale N. Experimentally derived model for the locomotor pattern generator in the Xenopus embryo. J. Physiol. (London). 489:1995;489-510.
10. Grillner S., McClellan A., Sigvardt K., Wallén P., Wilén M. Activation of NMDA-receptors elicits 'fictive locomotion' in lamprey spinal cord in vitro. Acta Physiol. Scand. 113:1981;349-551.
11. Harris-Warrick R.M., Cohen A.H. Serotonin modulates the central pattern generator for locomotion in the isolated lamprey spinal cord. J. Exp. Biol. 116:1985;27-46.
12. Kiehn O., Kjaerulff O. Spatiotemporal characteristics of 5-HT and dopamine-induced rhythmic hindlimb activity in the in vitro neonatal rat. J. Neurophysiol. 75:1996;1472-1482.
13. J. Schotland, O. Shupliakov, M. Wikström, L. Brodin, M. Srinivasan, Z.B. You, Herrera-Marschnitz, W. Zhang, T. Hökfelt, S. Grillner, Control of Lamprey Locomotor Neurons by Colocalized Monoamine Transmitters, Nature 374 (1995) 266-268.
14. Schotland J.L., Grillner S. Effects of serotonin on fictive locomotion coordinated by a neural network deprived of NMDA receptor-mediated cellular properties. Exp. Brain Res. 93:1993;391-398.
15. Sillar K.T., Simmers A.J. 5-HT induces NMDA receptor-mediated intrinsic oscillations in embryonic amphibian spinal neurons. Proc. R. Soc. London. 255:1994;139-145.
16. Sillar K.T., Wedderburn J.F.S., Simmers A.J. Modulation of swimming rhythmicity by 5-hydroxytryptamine during post-embryonic development in Xenopus laevis. Proc. R. Soc. London. 250:1992;107-114.
17. Van Dongen P.A.M., Hökfelt T., Grillner S., Verhofstad A.A.J., Steinbusch H.W.M. Possible target neurons of 5-hydroxytryptamine fibers in the lamprey spinal cord: immunohistochemistry combined with intracellular staining with lucifer yellow. J. Comp. Neurol. 234:1985;523-535.
18. Wallén P., Buchanan J.T., Grillner S., Hill R., Christenson J., Hökfelt T. Effects of 5-hydroxytryptamine on the after hyperpolarization spike frequency regulation, and oscillatory membrane properties in lamprey spinal cord neurons. J. Neurophysiol. 62:1989;759-768.
19. Wallén P., Christenson J., Brodin L., Hill R., Lansner A., Grillner S. Mechanisms Underlying the Serotonergic Modulation of the Spinal Circuitry for Locomotion in Lamprey. 1989;321-327 Elsevier Science Publishers BV.
20. Zhang W., Pombal M.A., El Manira A., Grillner S. Rostrocaudal distribution of 5-HT innervation in the lamprey spinal cord and differential effects of 5-HT on fictive locomotion. J. Comp. Neurol. 374:1996;278-290.