The triggering of human peritoneal mesothelial cell apoptosis and oncosis by glucose and glycoxydation products

Nephrology Dialysis Transplantation

Volumn 19, Issue 9, 2004, Pages 2208-2216

  Boulanger, Eric ^a,b   Wautier, Marie Paule ^a   Gane, Pierre ^a   Mariette, Christophe ^c   Devuyst, Olivier ^d   Wautier, Jean Luc ^a  

^a INSTITUT NATIONAL DE LA TRANSFUSION SANGUINE   (France)

^b Clinique Néphrologique   (France)

^c LILLE UNIVERSITY HOSPITAL   (France)

^d UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

Author keywords

Apoptosis; Biocompatibility; Glycoxidation; Peritoneal dialysis

Indexed keywords

3 DEOXYGLUCOSONE; 6 N CARBOXYMETHYLLYSINE; ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; BICARBONATE; DNA; GLUCOSE; GLUCOSE DEGRADATION PRODUCT; ICODEXTRIN; LACTIC ACID; PERITONEAL DIALYSIS FLUID; PROPIDIUM IODIDE;

APOPTOSIS; ARTICLE; BIOCOMPATIBILITY; CELL DEATH; CELL FUNCTION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; FILTRATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTERCALATION COMPLEX; KIDNEY FAILURE; MEMBRANE POTENTIAL; MESOTHELIUM CELL; MITOCHONDRIAL MEMBRANE; PERITONEAL DIALYSIS; PERITONEUM CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR AFFINITY;

APOPTOSIS; CELL DEATH; CELL PROLIFERATION; CELLS, CULTURED; DIALYSIS SOLUTIONS; EPITHELIAL CELLS; EPITHELIUM; GLUCOSE; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; PERITONEAL DIALYSIS; PERITONEUM;

EID: 4544300340     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfh277     Document Type: Article

References (21)

1. Topley N. Membrane longevity in peritoneal dialysis: impact of infection and bio-incompatible solutions. Adv Ren Replace Ther 1998; 5: 179-184.
2. Witowski J, Bender T, Wisniewska-Elnur J et al. Mesothelial toxicity of peritoneal dialysis fluids is related primarily to glucose degradation products, not to glucose per se. Perit Dial Int 2003; 23: 381-390.
3. Miyata T, Ueda Y, Yamada Y et al. Accumulation of carbonyls accelerates the formation of pentosidine, an advanced glycation end product: carbonyl stress in uremia. J Am Soc Nephrol 1998; 9: 2349-2356.
4. Schmidt AM, Yan SD, Yan SF, Stern DM. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest 2001; 108: 949-955.
5. Boulanger E, Wautier M, Wautier J et al. AGEs bind to mesothelial cells via RAGE and stimulate VCAM-1 expression. Kidney Int 2002; 61: 148-156.
6. Majno G, Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 1995; 146: 3-15.
7. Morgan LW, Wieslander A, Davies M et al. Glucose degradation products (GDP) retard remesothelialization independently of D-glucose concentration. Kidney Int 2003; 64: 1854-1866.
8. Ahmed N, Thornalley PJ. Quantitative screening of protein biomarkers of early glycation, advanced glycation, oxidation and nitrosation in cellular and extracellular proteins by tandem mass spectrometry multiple reaction monitoring. Biochem Soc Trans 2003; 31: 1417-1422.
9. Wautier MP, Massin P, Guillausseau PJ et al. N(carboxymethyl)lysine as a biomarker for microvascular complications in type 2 diabetic patients. Diabetes Metab 2003; 29: 44-52.
10. Wautier JL, Zoukourian C, Chappey O et al. Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats. J Clin Invest 1996; 97: 238-243.
11. Combet S, Miyata T, Moulin P, Pouthier D, Goffin E, Devuyst O. Vascular proliferation and enhanced expression of endothelial nitric oxide synthase in human peritoneum exposed to long-term peritoneal dialysis. J Am Soc Nephrol 2000; 11: 717-728.
12. Devuyst O, Nielsen S, Cosyns JP et al. Aquaporin-1 and endothelial nitric oxide synthase expression in capillary endothelia of human peritoneum. Am J Physiol 1998; 275: H234-H242.
13. Susin SA, Daugas E, Ravagnan L et al. Two distinct pathways leading to nuclear apoptosis. J Exp Med 2000; 192: 571-580.
14. Posthuma N, ter Wee PM, Niessen H, Donker AJ, Verbrugh HA, Schalkwijk CG. Amadori albumin and advanced glycation end-product formation in peritoneal dialysis using icodextrin. Perit Dial Int 2001; 21: 43-51.
15. Tanaka N, Yonekura H, Yamagishi S, Fujimori H, Yamamoto Y, Yamamoto H. The receptor for advanced glycation end products is induced by the glycation products themselves and tumor necrosis factor-alpha through nuclear factor-kappa B, and by 17beta-estradiol through Sp-1 in human vascular endothelial cells. J Biol Chem 2000; 275: 25781-25790.
16. Linden T, Cohen A, Deppisch R, Kjellstrand P, Wieslander A. 3,4-dideoxyglucosone-3-ene (3,4-DGE): a cytotoxic glucose degradation product in fluids for peritoneal dialysis. Kidney Int 2002; 62: 697-703.
17. Liu BE, Miyata S, Hirota Y et al. Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells. Kidney Int 2003; 63: 947-957.
18. De Vriese AS, Flyvbjerg A, Mortier S, Tilton RG, Lameire NH. Inhibition of the interaction of AGE-RAGE prevents hyperglycemia-induced fibrosis of the peritoneal membrane. J Am Soc Nephrol 2003; 14: 2109-2118.
19. Vincent AM, Brownlee M, Russell JW. Oxidative stress and programmed cell death in diabetic neuropathy. Ann N Y Acad Sci 2002; 959: 368-383.
20. Wautier MP, Chappey O, Corda S, Stern DM, Schmidt AM, Wautier JL. Activation of NADPH oxidase by advanced glycation end-products (AGEs) links oxidant stress to altered gene expression via RAGE. Am J Physiol Endocrinol Metab 2001; 280: E685-E694.
21. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414: 813-820.