Microarray analyses identify JAK2 tyrosine kinase as a key mediator of ligand-independent gene expression

American Journal of Physiology - Cell Physiology

Volumn 287, Issue 4 56-4, 2004, Pages

  Wallace, Tiffany A ^a   VonDerLinden, Dannielle ^a   He, Kai ^b   Frank, Stuart J ^b   Sayeski, Peter P ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

Janus kinase 2

Indexed keywords

CELL SURFACE RECEPTOR; JANUS KINASE 2; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL SURFACE; CLUSTER ANALYSIS; CONTROLLED STUDY; DNA MICROARRAY; ENZYME ACTIVATION; ENZYME ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; NULL ALLELE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; VALIDATION PROCESS;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; GENE EXPRESSION REGULATION; JANUS KINASE 2; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

ANIMALIA; JANUS;

EID: 4544280982     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00085.2004     Document Type: Article

References (42)

1. Bhat GJ, Thekkumkara TJ, Thomas WG, Conrad KM, and Baker KM. Activation of the STAT pathway by angiotensin II in T3CHO/AT1A cells. Cross-talk between angiotensin II and interleukin-6 nuclear signaling. J Biol Chem 270: 19059-19065, 1995.
2. Buggy JJ. Binding of alpha-melanocyte-stimulating hormone to its G-protein-coupled receptor on B-lymphocytes activates the Jak/STAT pathway. Biochem J 331: 211-216, 1998.
3. Chatti K, Farrar WL, and Duhe RJ. Tyrosine phosphorylation of the Janus kinase 2 activation loop is essential for a high-activity catalytic state but dispensable for a basal catalytic state. Biochem J 43: 4272-4283, 2004.
4. Chomczynski P and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
5. Cook SA, Matsui T, Li L, and Rosenzweig A. Transcriptional effects of chronic Akt activation in the heart. J Biol Chem 277: 22528-22533, 2002.
6. Darnell JE Jr, Kerr IM, and Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415-1421, 1994.
7. Doan TN, Ali MS, and Bernstein KE. Tyrosine kinase activation by the angiotensin II receptor in the absence of calcium signaling. J Biol Chem 276: 20954-20958, 2001.
8. Duhe RJ and Farrar WL. Structural and mechanistic aspects of Janus kinases: how the two-faced god wields a double-edged sword. J Interferon Cytokine Res 18: 1-15, 1998.
9. Fan XD, Stark GR, and Bloom BR. Molecular cloning of a gene selectively induced by gamma Interferon from human macrophage cell line U937. Mol Cell Biol 9: 1922-1928, 1989.
10. Feng J, Witthuhn BA, Matsuda T, Kohlhuber F, Kerr IM, and Ihle JN. Activation of JAK2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol Cell Biol 17: 2497-2501, 1997.
11. Foley H, Ofori-Acquah SF, Yoshimura A, Critz S, Baliga S, and Pace BS. Stat3 beta inhibits gamma-globin gene expression in erythroid cells. J Biol Chem 277: 16211-16219, 2002.
12. 2+ and PKC-delta for Janus kinase 2 activation by angiotensin II: involvement of PYK2. Mol Endocrinol 16: 367-377, 2002.
13. Gadina M, Hilton D, Johnston JA, Morinobu A, Lighvani A, Zhou YJ, Visconti R, and O'Shea JJ. Signaling by type I and II cytokine receptors: ten years after. Curr Opin Immunol 13: 363-373, 2001.
14. Giulietti A, Overbergh L, Valckx D, Decallonne B, Bouillon R, and Mathieu C. An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods 25: 386-401, 2001.
15. He K, Wang X, Jiang J, Guan R, Bernstein KE, Sayeski PP, and Frank SJ. Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling. Mol Endocrinol 17: 2211-2227, 2003.
16. Horowitz DS, Lee EJ, Mabon SA, and Misteli T. A cyclophilin functions in pre-mRNA splicing. EMBO J 21: 470-480, 2002.
17. Ju H, Venema VJ, Liang H, Harris MB, Zou R, and Venema RC. Bradykinin activates the Janus-activated kinase/signal transducers and activators of transcription (JAK/STAT) pathway in vascular endothelial cells: localization of JAK/STAT signalling proteins in plasmalemmal caveolae. Biochem J 351: 257-264, 2000.
18. Kohlhuber F, Rogers NC, Watling D, Feng J, Guschin D, Briscoe J, Witthuhn BA, Kotenko SV, Pestka S, Stark GR, Ihle JN, and Kerr IM. A JAK1/JAK2 chimera can sustain alpha and gamma Interferon responses. Mol Cell Biol 17: 695-706, 1997.
19. Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, and Shuai K. Inhibition of Stall-mediated gene activation by PIAS1. Proc Natl Acad Sci USA 95: 10626-10631, 1998.
20. ΔΔC1 method. Methods 25: 402-408, 2001.
21. Lukashova V, Chen Z, Duhe RJ, Rola-Pleszczynski M, and Stankova J. Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus. J Immunol 171: 3794-3800, 2003.
22. Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P, and Bernstein KE. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature 375: 247-250, 1995.
23. Mascareno E, Dhar M, and Siddiqui MA. Signal transduction and activator of transcription (STAT) protein-dependent activation of angiotensinogen promoter: a cellular signal for hypertrophy in cardiac muscle. Proc Natl Acad Sci USA 95: 5590-5594, 1998.
24. Mascareno E and Siddiqui MA. The role of Jak/STAT signaling in heart tissue renin-angiotensin system. Mol Cell Biochem 212: 171-175, 2000.
25. Matsuoka H, Iwata N, Ito M, Shimoyama M, Nagata A, Chihara K, Takai S, and Matsui T. Expression of a kinase-defective Eph-like receptor in the normal human brain. Biochem Biophys Res Commun 235: 487-492, 1997.
26. Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, and Pfeffer K. JAK2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93: 397-409, 1998.
27. Pan J, Fukuda K, Kodama H, Makino S, Takahashi T, Sano M, Hori S, and Ogawa S. Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart. Circ Res 81: 611-617, 1997.
28. Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, Van Deursen JM, Grosveld G, and Ihle JN. JAK2 is essential for signaling through a variety of cytokine receptors. Cell 93: 385-395, 1998.
29. Park OK, Schaefer TS, and Nathans D. In vitro activation of Stat3 by epidermal growth factor receptor kinase. Proc Natl Acad Sci USA 93: 13704-13708, 1996.
30. Peeler TC, Conrad KM, and Baker KM. Endothelin stimulates sis-inducing factor-like DNA binding activity in CHO-K1 cells expressing ETA receptors. Biochem Biophys Res Commun 221: 62-66, 1996.
31. Rome S, Clement K, Rabasa-Lhoret R, Loizon E, Poitou C, Barsh GS, Riou JP, and Laville H. Microarray profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp. J Biol Chem 278: 18063-18068, 2003.
32. Rozovskaia T, Ravid-Amir O, Tillib S, Getz G, Feinstein E, Agrawal H, Nagler A, Rappaport EF, Issaeva I, Matsuo Y, Kees UR, Lapidot T, Lo Coco F, Foa R, Mazo A, Nakamura T, Croce CM, Cimino G, Domany E, and Canaani E. Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements. Proc Natl Acad Sci USA 100: 7853-7858, 2003.
33. Sandberg EM, Ma X, VonDerLinden D, Godeny MD, and Sayeski PP. JAK2 tyrosine kinase mediates angiotensin II-dependent inactivation of ERK2 via induction of mitogen-activated protein kinase phosphatase 1. J Biol Chem 279: 1956-1957, 2004.
34. 1 adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells. Biochem Biophys Res Commun 268: 25-30, 2000.
35. 2+, and protein kinase C. Circ Res 82: 1279-1288, 1998.
36. Sayeski PP, Ali MS, Safavi A, Lyles M, Kim SO, Frank SJ, and Bernstein KE. A catalytically active JAK2 is required for the angiotensin II-dependent activation of Fyn. J Biol Chem 274: 33131-33142, 1999.
37. Sayeski PP and Kudlow JE. Glucose metabolism to glucosamine is necessary for glucose stimulation of transforming growth factor-alpha gene transcription. J Biol Chem 271: 15237-15243, 1996.
38. Seki Y, Kai H, Shibata R, Nagata T, Yasukawa H, Yoshimura A, and Imaizumi T. Role of the JAK/STAT pathway in rat carotid artery remodeling after vascular injury. Circ Res 87: 12-18, 2000.
39. Sells MA, Knaus UG, Bagrodia S, Ambrose DM, Bokoch GM, and Chernoff J. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol 7: 202-210, 1997.
40. Von DerLinden D, Ma X, Sandberg EM, Gernert K, Bernstein KE, and Sayeski PP. Mutation of glutamic acid residue 1046 abolishes JAK2 tyrosine kinase activity. Mol Cell Biochem 241: 87-94, 2002.
41. Wen T, Bukczynski J, and Watts TH. 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. J Immunol 168: 4897-4906, 2002.
42. Zhuang H, Patel SV, He TC, Sonsteby SK, Niu Z, and Wojchowski DM. Dominant negative effects of a carboxy-truncated JAK2 mutant on Epo-induced proliferation and JAK2 activation. J Biol Chem 269: 21411-21414, 1994.