Infarct reduction in rats following intraventricular administration of either tissue plasminogen activator (tPA) or its non-protease mutant S478A-tPA

Experimental Neurology

Volumn 189, Issue 2, 2004, Pages 354-360

  Yi, Jung Sun ^a   Kim, Yang Hee ^b   Koh, Jae Young ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Sejong University   (South Korea)

Author keywords

Excitotoxicity; Ischemia; Neuroprotection; NMDA; Protease; Zinc

Indexed keywords

ALTEPLASE; N METHYL DEXTRO ASPARTIC ACID; RECOMBINANT PROTEIN; S478A RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY OCCLUSION; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION; BRAIN SLICE; BRAIN VENTRICLE; CELL CULTURE; CELL PROTECTION; CONTROLLED STUDY; DENATURATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; FETUS; HEATING; MIDDLE CEREBRAL ARTERY; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; REDUCTION KINETICS;

ANIMALS; BRAIN; BRAIN INFARCTION; BRAIN ISCHEMIA; CELLS, CULTURED; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; ENDOPEPTIDASES; FETUS; INFARCTION, MIDDLE CEREBRAL ARTERY; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MOVEMENT DISORDERS; MUTATION; N-METHYLASPARTATE; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME; ZINC;

EID: 4544271208     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2004.05.032     Document Type: Article

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