Gonadotropin response to clomiphene and plasma leptin levels in weight recovered but amenorrhoeic patients with anorexia nervosa

Journal of Endocrinological Investigation

Volumn 27, Issue 6, 2004, Pages 523-527

  Djurovic, M ^a,c   Pekic, S ^a,c   Petakov, M ^a,c   Damjanovic, S ^a,c   Doknic, M ^a,c   Dieguez, C ^b   Casanueva, F F ^b   Popovic, Ver ^a,c  

^a CLINICAL CENTER OF SERBIA   (Serbia)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

Author keywords

Anorexia nervosa; Clomiphene gonadotropins; Leptin

Indexed keywords

CLOMIFENE CITRATE; ESTRADIOL; FOLLITROPIN; GONADOTROPIN; LEPTIN; LUTEINIZING HORMONE;

ADULT; AMENORRHEA; ANOREXIA NERVOSA; ARTICLE; BEHAVIOR THERAPY; BODY COMPOSITION; BODY FAT; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FAT INTAKE; FEMALE; HORMONE BLOOD LEVEL; HORMONE RELEASE; HUMAN; HYPOTHALAMUS; MENSTRUAL CYCLE; NUTRITIONAL DISORDER; PSYCHOLOGICAL ASPECT; REPRODUCTION; WEIGHT GAIN;

EID: 4544257919     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03347473     Document Type: Article

References (19)

1. Grinspoon S, Thomas L, Miller K, Pitts S, Herzog D, Klibanski A. Changes in regional fat redistribution and effects of estrogen during spontaneous weight gain in women with anorexia nervosa. Am J Clin Nutr 2001, 73: 865-9.
2. Friedman M. Leptin and the neural circuit regulating body weight and metabolism In: Kordon C, Robinson I, Hanoune J, Dantzer R, Christen Y, eds. Brain somatic cross-talk and the central control of metabolism. Berlin, Heidelberg, New York: Springer-Verlag. 2003. 15-35.
3. Considine R, Sinha M, Heiman M, et al. Serum immunoreactive-leptin concentrations in normal weight obese humans. N Engl J Med 1996, 334: 292-5.
4. Boden G, Chen X, Mozzoli M, Ryan I. Effect of fasting on serum leptin in normal subjects. J Clin Endocrinol Metab 1996, 81: 3419-23.
5. Mantzoros C, Moschos S. Leptin: in search of role(s) in human physiology and pathophysiology. Clin Endocrinol (Oxf) 1998, 49: 551-67.
6. Miller K, Parulekar M, Schoenfeld E, et al. Decreased leptin levels in normal weight women with hypothalamic amenorrhea: the effects of body composition and nutritional intake J Clin Endocrinol Metab 1998, 83: 2309-12.
7. Aihma R, Prakakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996, 382:250-2.
8. Farooqui I, Jebb S, Langmack G, et al. Effects of recombinant leptin therapy in a child with congenital leptin defciency. N Engl J Med 1999, 341: 879-84.
9. Oral E, Simha V, Ruiz E, et al. Leptin-replacement therapy for lipodystrophy. N Engl J Med 2002, 346: 570-8.
10. Stoving R, Vinten J, Handberg A, et al. Diurnal variation of the serum leptin concentration in patients with anorexia nervosa. Clin Endocrinol (Oxf) 1998, 48: 761-8.
11. Casanueva FF, Dieguez C, Popovic V, Peino R, Caro J. Serum immunoreactive-leptin concentrations in patients with anorexia nervosa before and after partial weight recovery. Biochem Mol Med 1997, 60: 116-120
12. Mantzoros C, Flier J, Lesem M, Breweton T, Jimerson D. Cerebrospinal fluid leptin in anorexia nervosa: correlation with nutritional status and potential role in resistance to weight gain. J Clin Endocrinol Metab 1997, 82: 1845-51.
13. Considine R, Sinha M, Heiman M, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996, 334: 292-5.
14. Yiannakouris N, Melistas L, Yannakoulia M, Mungal K, Mantzoros C. The -2548G/A plymorphism in the human leptin gene promoter region is associated with plasma free leptin levels;interaction with adiposity and gender in healthy subjects. Hormones 2003, in press.
15. Kratz M, von Eckardstein A, Fobker M, et al. The impact of dietary fat composition on serum leptin concentrations in healthy nonobese men and women. J Clin Endocrinol Metab 2003, 87: 5008-14.
16. Yannakoulia M, Yiannakouris N, Blueher S, Matals A, Klimis-Zacas A, Mantzoros C. Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin and resistin concentrations in healthy humans. J Clin Endocrinol Metab 2003, 88: 1730-6.
17. Mantzoros CS. The role of leptin in human obesity and disease: a review of current evidence. Ann Internal Med 1999, 130: 671-680.
18. Grinspoon S, Gulick T, Askari H, et al. Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab 1996, 81: 3861-3.
19. Chan J, Heist K, DePaoli A, Velghius J, Mantzoros C. The role of failing leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest 2003, 111: 1409-21