Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery

Journal of Medicinal Chemistry

Volumn 47, Issue 20, 2004, Pages 4802-4805

  Miller, Michael L ^a   Roller, Elizabeth E ^a   Zhao, Robert Y ^a   Leece, Barbara A ^a   Ab, Olga ^a   Baloglu, Erkan ^a   Goldmacher, Victor S ^a   Chari, Ravi V J ^a  

^a IMMUNOGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIBODY CONJUGATE; BUFFER; DOCETAXEL; PACLITAXEL; TAXANE DERIVATIVE; TAXOID;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; TUMOR;

ANTINEOPLASTIC AGENTS; BIOCHEMISTRY; BREAST NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; DISULFIDES; DRUG CARRIERS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; LUNG NEOPLASMS; PACLITAXEL; POLYETHYLENE GLYCOLS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TAXOIDS; TUMOR CELLS, CULTURED;

EID: 4544228227     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049705s     Document Type: Article

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