Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 15, 2004, Pages 4079-4082

  Miller, Michael L ^a   Roller, Elizabeth E ^a   Wu, Xinyaun ^b   Leece, Barbara A ^a   Goldmacher, Victor S ^a   Chari, Ravi V J ^a   Ojima, Iwao ^b  

^a IMMUNOGEN INC   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Antibody conjugate; Targeted delivery; Taxoid; Tumor specific

Indexed keywords

DOCETAXEL; MONOCLONAL ANTIBODY; PACLITAXEL; TAXANE DERIVATIVE; TAXOID;

ANTIBODY SPECIFICITY; ARTICLE; CHEMICAL MODIFICATION; CONJUGATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SYNTHESIS;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PACLITAXEL; STRUCTURE-ACTIVITY RELATIONSHIP; TAXOIDS;

EID: 3042549922     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.05.027     Document Type: Article

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