Selectively increased trace conditioning under the neurotensin agonist PD 149163 in an aversive procedure in which SR 142948A was without intrinsic effect

Journal of Psychopharmacology

Volumn 22, Issue 3, 2008, Pages 290-299

  Grimond Billa, S K ^a   Norman, C ^a   Bennett, G W ^a   Cassaday, H J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Aversive conditioning; Neurotensin; PD 149163; Rat; SR 1 42948A; Trace conditioning

Indexed keywords

2 [5 (2,6 DIMETHOXYPHENYL) 1 [4 [N (3 DIMETHYLAMINOPROPYL) N METHYLCARBAMOYL] 2 ISOPROPYLPHENYL] 1H PYRAZOL 3 YLCARBONYLAMINO]ADAMANTANE 2 CARBOXYLIC ACID; DOPAMINE RECEPTOR STIMULATING AGENT; NEUROTENSIN DERIVATIVE; NOOTROPIC AGENT; PD 141963; PD 149163;

ANIMAL EXPERIMENT; ARTICLE; CONDITIONING; CONTROLLED STUDY; DOSE RESPONSE; DRINKING; DRUG DOSE COMPARISON; FOOTSHOCK; LATENT INHIBITION; MALE; NOISE; NONHUMAN; PRIORITY JOURNAL; RAT; STATE DEPENDENT LEARNING; STIMULUS RESPONSE;

ADAMANTANE; ANIMALS; ASSOCIATION LEARNING; AVOIDANCE LEARNING; COGNITION; CONDITIONING, OPERANT; CUES; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSHOCK; IMIDAZOLES; MALE; NEUROTENSIN; RATS; RATS, WISTAR; REINFORCEMENT (PSYCHOLOGY); STIMULATION, CHEMICAL;

EID: 45349093964     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881106081528     Document Type: Article

References (75)

1. Austin J., Buckland P., Cardno A.G., Williams N., Spurlock G., Hoogendoorn B., Zammit S., Jones G., Sanders R., Jones L., McCarthy G., Jones S., Bray N.J., McGuffin P., Owen M.J., O'Donovan M.C. (2000) The high affinity neurotensin receptor gene (NTSR1). comparative sequencing and association studies in schizophrenia. Mol Psychiatry 5: 552-557
2. Azmi N., Norman C., Spicer C.H., Bennett G.W. (2006) Effects of a neurotensin analogue (PD149163) and antagonist (SR142948A) on the scopolamine-induced deficits in a novel object discrimination task. Behav Pharmacol 17: 357-362
3. Bennett T.L., Hebert P.N., Moss D.E. (1973) Hippocampal theta activity and the attention component of discrimination learning. Behav Biol 8: 173-181
4. Berod A., Rostène W. (2002) Neurotensin: an endogenous psychostimulant? Commentary. Curr Opin Pharmacol 2: 93-98
5. Betancur C., Canton M., Burgos A., Labeeuw B., Gully D., Rostene W., Pelaprat D. (1998) Characterization of binding sites of a new neurotensin receptor antagonist, [3H]SR 142948A, in the rat brain. Eur J Pharmacol 343: 67-77
6. Binder E.B., Kinkead B., Owens M.J., Nemeroff C.B. (2001 a) The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs. Biol Psychiatry 50: 856-872
7. Binder E.B., Kinkead B., Owens M.J., Nemeroff C.B. (2001 b) Neurotensin and dopamine interactions. Pharmacol Rev 53: 453-486
8. Binder E.B., Kinkead B., Owens M.J., Kilts C.D., Nemeroff C.B. (2001 c) Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating. J Neurosci 21: 601-608
9. Binder E.B., Gross R.E., Nemeroff C.B., Kilts C.D. (2002) Effects of neurotensin receptor antagonism on latent inhibition in Sprague-Dawley rats. Psychopharmacology 161: 288-295
10. Boules M., Fredrickson P., Richelson E. (2003) Current topics: brain penetrating neurotensin analogue. Life Sci 73: 2785-2792
11. Broderick P.A., Piercey M.F. (1998) Clozapine, haloperidol, and the D4 antagonist PNU-101387G: in vivo effects on mesocortical, mesolmbic, and nigrostrial dopamine and serotonin release. J Neural Transm 105: 749-767
12. Caceda R., Kinkead B., Nemeroff C.B. (2003) Do neurotensin receptor agonists represent a novel class of antipsychotic drugs? Semin Clin Neuropsychiatry 8: 94-108
13. Carraway R., Leeman S.E. (1973) The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J Biol Chem 248: 6854-6861
14. Carraway R., Leeman S.E. (1976) Radioimmunoassay for neurotensin, a hypothalamic peptide. J Biol Chem 25: 7035-7044
15. Cassaday H.J., Rawlins J.N.P. (1997) The hippocampus, objects and their contexts. Behav Neurosci 111: 1228-1244
16. Cassaday H.J., Horsley R.R., Norman C. (2005 a) Electrolytic lesions to nucleus accumbens core and shell have dissociable effects on conditioning to discrete and contextual cues in aversive and appetitive procedures respectively. Behav Brain Res 160: 222-235
17. Cassaday H.J., Nelson A.J., Norman C. (2005 b) Haloperidol can increase responding to both discrete and contextual cues in trace-conditioned rats. Behav Brain Res 158: 31-42
18. Clineschmidt B.V., McGuffin J.C., Bunting P.B. (1979) Neurotensin: antinocisponsive action in rodents. Eur J Pharmacol 54: 129-139
19. Crider A., Solomon P.R., McMahon M.A. (1982) Disruption of selective attention in the rat following chronic D-amphetamine administration: relationship to schizophrenic attention disorder. Biol Psychiatry 17: 351-361
20. Dobner P.R., Deutch AY, Fadel J. (2003) Neurotensin: dual roles in psychostimulant and antipsychotic drug responses. Life Sci 73: 801-811
21. Ellison G.D., Eison M.S. (1983) Continuous amphetamine intoxication: an animal model of acute psychotic episode. Psychol Med 13: 751-761
22. Feifel D., Minor K.L., Dulawa S., Swerdlow N.R. (1997) The effects of intra-accumbens neurotensin on sensorimotor gating. Brain Res 760: 80-84
23. Feifel D., Reza TL, Robeck SL (1998) Pro-dopamine effects of neurotensin on sensorimotor gating deficits. Peptides 18: 1457-1460
24. Feifel D., Reza T.L., Wustrow D.J., Davis M.D. (1999) Novel antipsychotic-like effects on prepulse inhibition of startle produced by a neurotensin agonist. J Pharmacol Exp Ther 288: 710-713
25. Gray N.S., Pickering A.D., Hemsley D.R., Dawling S., Gray J.A. (1992) Abolition of latent inhibition by a single 5 mg dose of D-amphetamine in man. Psychopharmacology 107: 425-430
26. Gully D., Labeeuw B., Boigegrain R., Oury-Donat F., Bachy A., Poncelet M., Steinberg R., Suaud-Chagny M.F., Santucci V., Vita N., Pecceu F., Labbe-Jullie C., Kitabgi P., Soubrie P., Le Fur G., Maffreand J.P. (1997) Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J Pharmacol Exp Ther 280: 802-812
27. Gully D., Canton M., Boigegrain R., Jeanjean F., Molimard J.C., Poncelet M., Gueudet C., Heaulme M., Leyris R., Brouard A., Peleprat D., Labbe-Jullie C., Mazella J., Soubrie P., Maffrand J.P., Rostene W., Kitabgi P., Le Fur G.L. (1993) Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor. Proc Natl Acad Sci USA 90: 65-69
28. Hanson G.R., Bush L. G, Taylor V.L., Gibb J.W., Davis K., Schmidt C.J. (1997) Comparison of neurotensin responses to MDL 100 907, a selective 5HT2A antagonist, with clozapine and haloperidol. Brain Res Bull 42: 211-219
29. Hertel P., Kurre Olsen C., Arnt J. (2002) Repeated administration of the neurotensin analogue NT69L induces tolerance to its suppressant effect on conditioned avoidance behaviour. Eur J Pharmacol 439: 107-111
30. Holtom P.E., Needham P.L., Bennett G.W., Aspley S. (2000) Chronic, but not acute, dosing of antipsychotic drugs alters neurotensin binding in rat brain regions. B J Pharmacol 131: 990-996
31. Horsley R.R., Cassaday H.J. (2007) Methylphenidate can reduce selectivity in associative learning in an aversive trace-conditioning task. J Psychopharmacol 21: 498-500
32. Jacobsen L., Madsen P., Jacobsen C., Nielsen M.S., Gliemann J., Petersen C.M. (2001) Activation and functional characterization of the mosaic receptor SorLA/LR11. J Biol Chem 22: 22788-22796
33. Jones S.H., Hemsley D., Ball S., Serra A. (1997) Disruption of the Kamin blocking effect in schizophrenia and in normal subjects following amphetamine. Behav Brain Res 88: 103-114
34. Kalivas P.W., Nemeroff C.B., Prange Jr A.J. (1984) Neurotensin microinjection into the nucleus accumbens antagonizes dopamine-induced increase in locomotion and rearing. Neuroscience 11: 919-930
35. Kamin L.J. (1965) Temporal and intensity characteristics of the conditioned stimulus. In Prokasy WF (ed). Classical conditioning: a symposium. Appleton-Century-Crofts, New York
36. Kantini E., Norman C., Cassaday H.J. (2004) Amphetamine decreases the expression and acquisition of appetitive conditioning but increases the acquisition of anticipatory responding over a trace interval. J Psychopharmacol 18: 516-526
37. Kinkead B., Binder E.B., Nemeroff C.B. (1999) Does neurotensin mediate the effects of antipsychotic drugs? Biol Psychiatry 46: 340-351
38. Kumari V., Cotter P.A., Mulligan O.F., Checkley S.A., Gray N.S., Hemsley D.R., Thornton J.C., Corr P.J., Toone B.K., Gray J.A. (1999) Effects of D-amphetamine and haloperidol on latent inhibition in healthy male volunteers. J Psychopharmacol 13: 398-405
39. Matthews R.T. (1999) Neurotensin depolarizes cholinergic and a subset of non-cholinergic septal/diagonal band neurons by stimulating neurotensin-1 receptors. Neuroscience 94: 775-783
40. Mazella J. (2001) Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking? Cell Signal 13: 1-6
41. Miller R.R., Matzel L.D. (1988) The comparator hypothesis: a response rule for the expression of associations. In Bower G H (ed). The psychology of learning and motivation 22: 51-92. San Diego, CA: Academic Press
42. Morin A.J., Tajani M., Jones B.E., Beaudet A. (1996) Spatial relationship between neurotensinergic axons and cholinergic neurons in the rat basal forebrain: a light microscopic study with three-dimensional reconstruction. J Chem Neuroanat 10: 147-156
43. Motoi Y., Aizawa T., Haga S., Nakamura S., Namba Y., Ikeda K. (1999) Neuronal localization of a novel mosaic apolipoprotein E receptor, LR11, in rat and human brain. Brain Res 3: 209-215
44. Muir J.L., Dunnett S.B., Robbins T.W., Everitt B.J. (1992) Attentional functions of the forebrain cholinergic systems: effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task. Exp Brain Res 89: 611-622
45. Nakachi N., Yamada M., Cho T., Coleman N.J., Yamada M., Richelson E. (1995) Expression of messenger RNA for neurotensin in rat brain cholinergic neurons. Biol Psychiatry 37: 642-642
46. Nemeroff C.B. (1980) Neurotensin: perchance an endogenous neuroleptic? Biol Psychiatry 15: 283-302
47. Nemeroff C.B. (1986) The interaction of neurotensin with dopaminergic pathways in the central nervous system: basic neurobiology and implications for the pathogenesis and treatment of schizophrenia. Psychoneuroendocrinology 11: 15-37
48. Norman C., Cassaday H.J. (2003) Amphetamine increases aversive conditioning to diffuse contextual stimuli and to a discrete trace stimulus when conditioned at higher footshock intensity. J Psychopharmacol 17: 67-76
49. Norman C., Cassaday H.J. (2004) Disruption of latent inhibition to a contextual stimulus with systemic amphetamine. Neurobiol Learn Mem 82: 61-64
50. Odling-Smee F.J. (1975) Background stimuli and the interstimulus interval during Pavlovian conditioning. Q J Exp Psychol B 27: 387-392
51. Ohad D., Lubow R.E., Weiner I., Feldon J. (1987) The effects of amphetamine on blocking. Psychobiology 15: 137-143
52. Osbahr A.J., Nemeroff C.B., Luttinger D., Mason G A., Prange Jr A.J. (1981) Neurotensin-induced antinociception in mice: antagonism by thyrotropin-releasing hormone. J Pharmacol Exp Ther 217: 645-651
53. Parkinson J.A., Robbins T.W., Everitt B.J. (1999) Selective excitotoxic lesions of the nucleus accumbens core and shell differentially affect aversive Pavlovian conditioning to discrete and contextual cues. Psychobiology 27: 256-266
54. Petrie K.A., Bubser M., Casey C.D., Davis M.D., Rothe B.L., Beutch A.Y. (2004) The neurotensin agonist PD149163 increases fos expression in the prefrontal cortex of the rat. Neuropsychopharmacology 29: 1878-1888
55. Pezze M.A., Heidbreder C.A., Feldon J., Murphy C.A. (2001) Selective responding of nucleus accumbens core and shell dopamine to aversively conditioned contextual and discrete stimuli. Neuroscience 108: 91-102
56. Prange Jr A.J., Nemeroff C.B. (1982) The manifold actions of neurotensin: a first synthesis. Ann N Y Acad Sci 400: 368-375
57. Rawlins J.N.P., Tanner J. (1998) The effects of hippocampal aspiration lesions on conditioning to the CS and to a background stimulus in trace conditioned suppression. Behav Brain Res 91: 61-72
58. Rescorla R.A., Wagner A.R. (1972) A theory of Pavlovian conditioning: variations in the effectiveness of reinforcement and nonreinforcement. In Black A H, Prokasy W F (eds). Classical conditioning II: current theory and research. Appleton-Century-Crofts, New York
59. Robledo R., Maldonado R., Koob G.F. (1993) Neurotensin injected into the nucleus accumbens blocks the psychostimulant effects of cocaine but does not atttenuate cocaine self-administration in the rat. Brain Res 622: 105-112
60. Sakamoto N., Michel J.P., Kiyama H., Tohyama M., Kopp N., Pearson J. (1986) Neurotensin immunoreactivity in the human cingulate gyrus, hippocampal subiculum and mammillary bodies: its potential role in memory processing. Brain Res 375: 351-356
61. Shibata K., Furukawa T. (1988) The mammillary body, a potential site of action of neurotensin in passive avoidance behavior in rats. Brain Res 8: 117-124
62. Shilling P.D., Richelson E., Feifel D. (2003) The effects of systemic NT69L, a neurotensin agonist, on baseline and drug-disrupted prepulse inhibition. Behav Brain Res 143: 7-14
63. Shilling P.D., Melendez G., Priebe K., Richelson E., Feifel D. (2004) Neurotensin agonists block the prepulse inhibition deficits produced by a 5-HT2A and an alpha1 agonist. Psychopharmacology 175: 353-359
64. Skoog K.M., Cain S.T., Nemeroff C.B., (1986) Centrally administered neurotensin suppresses locomotor hyperactivity induced by D-amphetamine but not by scopolamine or caffeine. Neuropharmacology 25: 777-782
65. Solomon P.R., Crider A., Winkelman J.W., Turi A., Kamer R.M., Kaplan L.J. (1981) Disrupted latent inhibition in the rat with chronic amphetamine or haloperidol-induced supersensitivity: relationship to schizophrenic attention disorder. Biol Psychiatry 17: 743-756
66. Stewart M., Fox S.E. (1990) Do septal neurons pace the hippocampal theta rhythm? Trends Neurosci 13: 163-168
67. Szigethy E., Beaudet A. (1987) Selective association of neurotensin receptors with cholinergic neurons in the rat basal forebrain. Neurosci Lett 83: 47-52
68. Tanganelli S., O'Connor W.T., Ferraro L., Bianchi C., Beani L., Ungerstedt U., Fuxe K. (1994) Facilitation of GABA release by neurotensin is associated with a reduction of dopamine release in rat nucleus accumbens. Neuroscience 60: 649-657
69. Van Wimersma Greidanus T.B., van Praag M.C., Kalmann R., Rinkel G.J., Croiset G., Hoeke E.C., van Egmond M.A., Fekete M. (1982) Behavioral effects of neurotensin. Ann N Y Acad Sci 400: 319-329
70. Vincent J.P., Mazella J., Kitabgi P. (1999) Neurotensin and neurotensin receptors. Trends Pharmacol Sci 20: 302-309
71. Weiner I. (1990) Neural substrates of latent inhibition: the switching model. Psychol Bull 108: 42-61
72. Weiner I., Lubow R.E., Feldon J. (1981) Chronic amphetamine and latent inhibition. Behav Brain Res 2: 285-286
73. Weiner I., Lubow R.E., Feldon J. (1988) Disruption of latent inhibition by acute administration of low doses of amphetamine. Pharmacol Biochem Behav 30: 871-878
74. Widerlov E., Lindstrom L.H., Besev G., Manberg P.J., Nemeroff C.B., Breese G.R., Kizer J.S., Prange Jr A.J. (1982) Subnormal CSF levels of neurotensin in a subgroup of schizophrenic patients: normalization after neuroleptic treatment. Am J Psychiatry 139: 1122-1126
75. Winocur G., Rawlins J.N.P., Gray J.A. (1987) The hippocampus and conditioning to contextual cues. Behav Neurosci 101: 617-625