Effects of d-amphetamine and haloperidol on latent inhibition in healthy male volunteers

Journal of Psychopharmacology

Volumn 13, Issue 4, 1999, Pages 398-405

  Kumari, Veena ^a   Cotter, Paul A ^a   Mulligan, Owen F ^a   Checkley, Stuart A ^a   Gray, Nicola S ^a   Hemsley, David R ^a   Thornton, Jasper C ^a   Corr, Philip J ^a   Toone, Brian K ^a   Gray, Effrey A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

d amphetamine; Dopamine; Haloperidol; Latent inhibition; Psychoticism; Schizophrenia

Indexed keywords

AMPHETAMINE; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; HALOPERIDOL;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HUMAN; HUMAN EXPERIMENT; LATENT INHIBITION; LEARNING; MALE; PRIORITY JOURNAL;

EID: 0033386612     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: 10.1177/026988119901300411     Document Type: Article

References (60)

1. Allan L M, Williams J H, Wellman N A, Tomin J, Taylor E, Rawlins J N P (1995) Effects of tobacco smoking, schizotypy and number of pre-exposures on latent inhibition in healthy subjects. Person Individ Diff 19: 893-902
2. Barnes T R E (1989) A rating scale for drug-induced akathisia. Br J Psychiatry 154: 672-676
3. Baruch I, Hemsley D R, Gray J A (1988a) Differential performance of acute and chronic schizophrenics in a latent inhibition task. J Nerv Ment Dis 176: 598-606
4. Baruch I, Hemsley D R, Gray J A (1988b) Latent inhibition and 'psychotic proneness' in normal subjects. Person Indiv Diff 9: 777-783
5. Claridge G S, Broks P (1984) Schizotypy and hemisphere function. I. Theoretical considerations and measurement of schizotypy. Person Individ Diff 5: 633-648
6. Christison G W, Atwater G E, Dunn L A, Kilts C D (1988) Haloperidol enhancement of latent inhibition - relation to therapeutic action. Biol Psychiatry 23: 746-749
7. Dawe S, Gerada C, Russell M A H, Gray J A (1995) Nicotine intake in smokers increases following a single dose of haloperidol. Psychopharmacology 117: 110-115
8. De la Casa L G, Ruiz G, Lubow R E (1993a) Amphetamine-produced attenuation of latent inhibition is modulated by stimulus preexposure duration: implications for schizophrenia. Biol Psychiatry 33: 707-711
9. De la Casa L G, Ruiz G, Lubow R E (1993b) Latent inhibition and recall/recognition of irrelevant stimuli as a function of preexposure duration in high and low psychotic-prone normal subjects. Br J Psychol 84: 119-132
10. Dunn L A, Atwater G, Kilts C D (1993) Effects of antipsychotic drugs on latent inhibition: sensitivity and specificity of an animal behavioural model of clinical drug action. Psychopharmacology 112: 315-323
11. Eysenck H J, Eysenck S B G (1975) Manual of the Eysenck personality questionnaire. Hodder and Stoughton, London
12. 2 dopamine receptors and personality traits. Nature 385: 590
13. Feldon J, Weiner I (1991) The latent inhibition model of schizophrenic attention disorder: haloperidol and sulpiride enhance rats' ability to ignore irrelevant stimuli. Biol Psychiatry 29: 635-646
14. Gray J A, Feldon J, Rawlins J N P, Hemsley D R, Smith A D (1991) The neuropsychology of schizophrenia. Behav Brain Sci 14: 1-84
15. Gray J A, Joseph M H, Hemsley D R, Young A M J, Warburton E C, Boulenguez P, et al. (1995) The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia. Behav Brain Res 71: 19-31
16. Gray J A, Moran P M, Grigoryan G, Peters S L, Young A M, Joseph M H (1997) Latent inhibition: the nucleus accumbens connection revisited. Behav Brain Res 88: 27-34
17. Gray N S, Hemsley D R, Gray J A (1992a) Abolition of latent inhibition in acute, but not chronic, schizophrenics. Neurol Psychiatr Brain Res 1: 83-89
18. Gray N S, Pickering A D, Hemsley D R, Dawling S, Gray J A (1992b) Abolition of latent inhibition by a single 5-mg dose of d-amphetamine in man. Psychopharmacology 114: 657-664
19. 2 binding set in the basal ganglia using single photon emission tomography. Person Individ Diff 3: 431-434
20. 2 binding using SPET. Schizophr Res 17: 95-107
21. Gray N S, Pickering A D, Gray J A (1996) Increased schizotypy scores in normal volunteers following the oral-administration of d-amphetamine (abstract). Schizophr Res 18: 2-3
22. Hall G (1991) Perceptual and associative learning. Oxford University Press, New York
23. Joseph M H, Peters S L, Gray J A (1993) Nicotine blocks latent inhibition in rats: evidence of a critical role of increased functional activity of dopamine in the mesolimbic system at conditioning rather than at pre-exposure. Psychopharmacology 110: 187-192
24. Killcross A S, Robbins T W (1993) Differential effect of intra-accumbens and systemic amphetamine on latent inhibition using an on-baseline, within-subject conditioned suppression paradigm. Psychopharmacology 110: 479-489
25. King D J, Burke M, Lucas R A (1995) Antipsychotic drug-induced dysphoria. Br J Psychiatry 167: 480-482
26. Kumari V, Cotter P, Corr P J, Gray J A, Checkley S (1996a) Effect of clonidine on the human acoustic startle reflex. Psychopharmacology 123: 353-360
27. Kumari V, Checkley S A, Gray J A (1996b) Effect of cigarette smoking on prepulse inhibition of the acoustic startle reflex in healthy male smokers. Psychopharmacology 128: 54-60
28. Kumari V, Corr P J, Mulligan O, Cotter P, Checkley S, Gray J A (1997) Effects of acute administration of d-amphetamine and haloperidol on procedural learning in man. Psychopharmacology 129: 271-276
29. Lipp O V, Vaitl D (1992) Latent inhibition in human Pavlovian differential conditioning: effect of additional stimulation after preexposure and relation to schizotypal traits. Person Indiv Diff 13: 1003-1012
30. Lipp O V, Siddle D A T, Arnold S L (1994) Psychosis-proneness in a non-clinical sample. II A multi-experimental study of 'attentional malfunctioning'. Person Indiv Diff 15: 405-424
31. Lubow R E (1973) Latent inhibition. Psych Bull 79: 398-407
32. Lubow R E (1989) Latent inhibition and conditioned attention theory. Cambridge University Press, UK
33. Lubow R E, Gewirtz J C (1995) Latent inhibition in humans: data, theory, and implications for schizophrenia. Psych Bull 117: 87-103
34. Lubow R E, Schnur P, Rifkin B (1976) Latent inhibition and conditioned attention theory. J Exp Psychol (Anim Behav Proc) 2: 163-174
35. Lubow R E, Weiner I, Scholossberg A, Baruch I (1987) Latent inhibition and schizophrenia. Bull Psychon Soc 25: 464-467
36. Lubow R E, Ingberg-Sachs Y, Zalstein-Orda N, Gewirtz J C (1992) Latent inhibition in low and high 'psychotic-prone' normal subjects. Person Individ Diff 13: 563-572
37. McAllister K H (1997) A single administration of d-amphetamine prior to stimulus pre-exposure and conditioning attenuates latent inhibition. Psychopharmacology 130: 79-84
38. Nordström A, Farde L, Halldin C (1992) Time course of D2-dopamine receptor occupancy examined by PET after single oral doses of haloperidol. Psychopharmacology 106: 433-438
39. Ramaekers J G, Louwerens J W, Muntjewerff H M, De Bie A, Rosenzweig P, O'Hanlon J F (1997) Repeated dose effect of amisulpride 50 and 400 mg/day, haloperidol (4 mg/day) and placebo upon hedonic, cognitive, psychomotor and extrapyramidal motor functions in healthy volunteers. J Psychopharmacol 11: 201-209
40. Rochford S, Sen A P, Quirion R (1996) Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat. J Pharm Exp Ther 277: 1267-1275
41. Schmajuk N A, Lam Y-W, Gray J A (1996) Intent inhibition: a neural network approach. J Exp Psychol (Anim Behav Proc) 22: 321-349
42. Solomon P R, Staton D M (1982) Differential effects of microinjections of d-amphetamine into the nucleus accumbens or the caudate putamen on the rat's ability to ignore an irrelevant stimulus. Biol Psychiatry 16: 743-756
43. Solomon P R, Crider A, Winkelman J W, Turi A, Kamer R M, Kaplan L J (1981) Disrupted latent inhibition in the rat with chronic amphetamine or haloperidol-induced supersensitivity: relationship to schizophrenic attention disorder. Biol Psychiatry 16: 519-537
44. Swerdlow N R, Braff D L, Hartston H, Perry W, Geyer M A (1996) Latent inhibition in schizophrenia. Schizophr Res 20: 91-103
45. Thornton J C, Dawe S, Lee C, Capstick C, Corr P J, Cotter P, Frangou S, Gray N S, Russell M A H, Gray J A (1996) Effects of nicotine and amphetamine on latent inhibition in normal human subjects. Psychopharmacology 127: 164-173
46. Trimble K M, Bell R, King D J (1997) Enhancement of latent inhibition in the rat by the atypical agent remoxipride. Pharmacol Biochem Behav 56: 809-816
47. Vaitl D, Lipp O V (1997) Latent inhibition and autonomie responses: a psychophysiological approach. Behav Brain Res 88: 85-93
48. Wan S H, Matin S B, Azarnoff D L (1978) Kinetics, salivary excretion of amphetamine isomers, and effect of urinary pH. Clin Pharmacol Ther 23: 585-590
49. Warburton E C, Joseph M H, Feldon J, Weiner I, Gray J A (1994) Antagonism of amphetamine-induced disruption of latent inhibition by haloperidol and ondansetron: implications for a possible antipsychotic action of ondansetron. Psychopharmacology 114: 657-664
50. Weiner I (1990) Neural substrates of latent inhibition: the switching model. Psych Bull 10: 442-461
51. Weiner I, Feldon J (1987) Facilitation of latent inhibition by haloperidol. Psychopharmacology 91: 248-253
52. Weiner I, Lubow R E, Feldon J (1981) Chronic amphetamine and latent inhibition. Behav Brain Res 2: 285-286
53. Weiner I, Lubow R E, Feldon J (1984) Abolition of the expression but not the acquisition of latent inhibition by chronic amphetamine in rats. Psychopharmacology 83: 194-199
54. Weiner I, Feldon J, Katz J (1987) Facilitation of the expression but not the acquisition of latent inhibition by haloperidol in rats. Pharmacol Biochem Behav 26: 241-246
55. Weiner I, Lubow R E, Feldon J (1988) Disruption of latent inhibition by acute administration of low doses of amphetamine in rats. Pharmacol Biochem Behav 30: 871-878
56. Weiner I, Shofel A, Feldon J (1990) Disruption of latent inhibition by a low dose of amphetamine is antagonised by haloperidol and apomorphine. J Psychopharmacol 4: 255
57. Williams J H, Wellman N A, Geaney D P, Cowen P J, Feldon J, Rawlins J N P (1996) Antipsychotic drug effects in a model of schizophrenic attentional disorder: a randomized controlled trial of the effects of haloperidol on latent inhibition in healthy people. Biol Psychiatry 40: 1135-1143
58. Williams J H, Wellman N A, Geaney D P, Rawlins J N P, Feldon J, Cowen P J (1997a) Intravenous administration of haloperidol to healthy volunteers: lack of subjective effects but clear objective effects. J Psychopharmacol 11: 247-252
59. Williams J H, Wellman N A, Geaney D P, Feldon J, Cowen P J, Rawlins J N P (1997b) Haloperidol enhances latent inhibition in visual tasks in healthy people. Psychopharmacology 133: 262-268
60. Williams J H, Wellman N A, Geaney D P, Cowen P J, Feldon J, Rawlins J N P (1998) Reduced latent inhibition in people with schizophrenia: an effect of psychosis or of its treatment? Br J Psychiatry 172: 243-249