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Volumn 363, Issue 1502, 2008, Pages 2441-2451

The Leeuwenhoek lecture 2006. Microscopy goes cold: Frozen viruses reveal their structural secrets

Author keywords

Electron cryomicroscopy; Hepatitis B virus; Image processing; Virus structure

Indexed keywords

FREEZING; HEPATITIS; IMAGE PROCESSING; MICROSCOPY; MODELING; ULTRASTRUCTURE; VIRUS;

EID: 45249115226     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2007.2150     Document Type: Review
Times cited : (15)

References (39)
  • 1
    • 0021257186 scopus 로고
    • Cryo-electron microscopy of viruses
    • doi:10.1038/308032a0
    • Adrian, M., Dubochet, J., Lepault, J. & McDowall, A. W. 1984 Cryo-electron microscopy of viruses. Nature 308, 32-36. (doi:10.1038/308032a0)
    • (1984) Nature , vol.308 , pp. 32-36
    • Adrian, M.1    Dubochet, J.2    Lepault, J.3    McDowall, A.W.4
  • 2
    • 1842409555 scopus 로고    scopus 로고
    • Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy
    • doi:10.1038/386088a0
    • Böttcher, B., Wynne, S. A. & Crowther, R. A. 1997 Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy. Nature 386, 88-91. (doi:10.1038/386088a0)
    • (1997) Nature , vol.386 , pp. 88-91
    • Böttcher, B.1    Wynne, S.A.2    Crowther, R.A.3
  • 3
    • 0343147172 scopus 로고    scopus 로고
    • Peptides that block hepatitis B virus assembly: Analysis by cryomicroscopy, mutagenesis and transfection
    • doi:10.1093/emboj/17.23.6839
    • Böttcher, B., Tsuji, N., Takahashi, H., Dyson, M. R., Zhao, S., Crowther, R. A. & Murray, K. 1998 Peptides that block hepatitis B virus assembly: analysis by cryomicroscopy, mutagenesis and transfection. EMBO J. 17, 6839-6845. (doi:10.1093/emboj/17.23.6839)
    • (1998) EMBO J , vol.17 , pp. 6839-6845
    • Böttcher, B.1    Tsuji, N.2    Takahashi, H.3    Dyson, M.R.4    Zhao, S.5    Crowther, R.A.6    Murray, K.7
  • 4
    • 0742282661 scopus 로고    scopus 로고
    • London, UK: Current Science Group
    • Brenner, S. 1997 A life in science, p. 118. London, UK: Current Science Group.
    • (1997) A life in science , pp. 118
    • Brenner, S.1
  • 5
    • 9644260511 scopus 로고    scopus 로고
    • Envelopment of the hepatitis B virus nucleocapsid
    • doi:10.1016/j.virusres.2004.08.016
    • Bruss, V. 2004 Envelopment of the hepatitis B virus nucleocapsid. Virus Res. 106, 199-209. (doi:10.1016/j.virusres.2004.08.016)
    • (2004) Virus Res , vol.106 , pp. 199-209
    • Bruss, V.1
  • 6
    • 73649156890 scopus 로고
    • Physical principles in the construction of regular viruses
    • Caspar, D. L. D. & Klug, A. 1962 Physical principles in the construction of regular viruses. Cold Spring Harb. Symp. Quant. Biol. 27, 1-23.
    • (1962) Cold Spring Harb. Symp. Quant. Biol , vol.27 , pp. 1-23
    • Caspar, D.L.D.1    Klug, A.2
  • 7
    • 0029665272 scopus 로고    scopus 로고
    • A model-based approach for determining orientations of biological macromolecules imaged by cryoelectron microscopy
    • doi:10.1006/jsbi.1996. 0020
    • Cheng, R. H. & Baker, T. S. 1996 A model-based approach for determining orientations of biological macromolecules imaged by cryoelectron microscopy. J. Struct. Biol. 116, 120-130. (doi:10.1006/jsbi.1996. 0020)
    • (1996) J. Struct. Biol , vol.116 , pp. 120-130
    • Cheng, R.H.1    Baker, T.S.2
  • 8
    • 0037790884 scopus 로고    scopus 로고
    • Coexistence of two distinct secretion mutations (P5Tand I97L) in hepatitis B virus core produces a wild-type pattern of secretion
    • doi:10.1128/JVI.77.13.7673-7676.2003
    • Chua, P. K., Wen, Y.-M. & Shih, C. 2003 Coexistence of two distinct secretion mutations (P5Tand I97L) in hepatitis B virus core produces a wild-type pattern of secretion. J. Virol. 77, 7673-7676. (doi:10.1128/JVI.77.13.7673-7676.2003)
    • (2003) J. Virol , vol.77 , pp. 7673-7676
    • Chua, P.K.1    Wen, Y.-M.2    Shih, C.3
  • 9
    • 0030937751 scopus 로고    scopus 로고
    • Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy
    • doi:10.1038/386091a0
    • Conway, J. F., Cheng, N., Zlotnick, A., Wingfield, P. T., Stahl, S. J. & Steven, A. C. 1997 Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy. Nature 386, 91-94. (doi:10.1038/386091a0)
    • (1997) Nature , vol.386 , pp. 91-94
    • Conway, J.F.1    Cheng, N.2    Zlotnick, A.3    Wingfield, P.T.4    Stahl, S.J.5    Steven, A.C.6
  • 10
    • 36949077319 scopus 로고
    • Structure of small viruses
    • doi:10.1038/177473a0
    • Crick, F. H. C. & Watson, J. D. 1956 Structure of small viruses. Nature 177, 473-475. (doi:10.1038/177473a0)
    • (1956) Nature , vol.177 , pp. 473-475
    • Crick, F.H.C.1    Watson, J.D.2
  • 11
    • 0015242164 scopus 로고
    • Procedures for three-dimensional reconstruction of spherical viruses by Fourier synthesis from electron micrographs
    • doi:10.1098/rstb.1971.0054
    • Crowther, R. A. 1971 Procedures for three-dimensional reconstruction of spherical viruses by Fourier synthesis from electron micrographs. Phil. Trans. R. Soc. B 261, 221-230. (doi:10.1098/rstb.1971.0054)
    • (1971) Phil. Trans. R. Soc. B , vol.261 , pp. 221-230
    • Crowther, R.A.1
  • 12
    • 0028307177 scopus 로고
    • Three-dimensional structure of hepatitis B virus core particles determined by electron cryomicroscopy
    • doi:10.1016/0092-8674(94)90142-2
    • Crowther, R. A., Kiselev, N. A., Böttcher, B., Berriman, J. A., Borisova, G. P., Ose, V. & Pumpens, P. 1994 Three-dimensional structure of hepatitis B virus core particles determined by electron cryomicroscopy. Cell 77, 943-950. (doi:10.1016/0092-8674(94)90142-2)
    • (1994) Cell , vol.77 , pp. 943-950
    • Crowther, R.A.1    Kiselev, N.A.2    Böttcher, B.3    Berriman, J.A.4    Borisova, G.P.5    Ose, V.6    Pumpens, P.7
  • 13
    • 0020631902 scopus 로고
    • Structure of the hepatitis B virus genome
    • Delius, H., Gough, N. M., Cameron, C. H. & Murray, K. 1983 Structure of the hepatitis B virus genome. J. Virol. 47, 337-343.
    • (1983) J. Virol , vol.47 , pp. 337-343
    • Delius, H.1    Gough, N.M.2    Cameron, C.H.3    Murray, K.4
  • 14
    • 0347928672 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids
    • doi:10.1126/science.1077215
    • Deres, K. et al. 2003 Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids. Science 299, 893-896. (doi:10.1126/science.1077215)
    • (2003) Science , vol.299 , pp. 893-896
    • Deres, K.1
  • 15
    • 0000668797 scopus 로고
    • Reconstruction of three dimensional structures from electron micrographs
    • doi:10.1038/217130a0
    • DeRosier, D. J. & Klug, A. 1968 Reconstruction of three dimensional structures from electron micrographs. Nature 217, 130-134. (doi:10.1038/217130a0)
    • (1968) Nature , vol.217 , pp. 130-134
    • DeRosier, D.J.1    Klug, A.2
  • 16
    • 85020780398 scopus 로고    scopus 로고
    • Dobell, C. 1932 Anthony van Leeuwenhoek and his 'little animals'. (Re-issued New York, 1958).
    • Dobell, C. 1932 Anthony van Leeuwenhoek and his 'little animals'. (Re-issued New York, 1958).
  • 18
    • 0028928193 scopus 로고
    • Selection of peptide inhibitors of interactions involved in complex protein assemblies: Association of the core and surface antigens of hepatitis B virus
    • doi:10.1073/pnas.92.6.2194
    • Dyson, M. R. & Murray, K. 1995 Selection of peptide inhibitors of interactions involved in complex protein assemblies: association of the core and surface antigens of hepatitis B virus. Proc. Natl Acad. Sci. USA 92, 2194-2198. (doi:10.1073/pnas.92.6.2194)
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 2194-2198
    • Dyson, M.R.1    Murray, K.2
  • 19
    • 0001435504 scopus 로고    scopus 로고
    • Hepadnaviridae: The viruses and their replication
    • eds D. Knipe & P. Howley, pp, Philadelphia, PA: Lippincott
    • Ganem, D. & Schneider, R. J. 2001 Hepadnaviridae: the viruses and their replication. In Fields virology (eds D. Knipe & P. Howley), pp. 2923-2969. Philadelphia, PA: Lippincott.
    • (2001) Fields virology , pp. 2923-2969
    • Ganem, D.1    Schneider, R.J.2
  • 20
    • 2542463976 scopus 로고    scopus 로고
    • An amino-terminal segment of hantavirus nucleocapsid protein presented on hepatitis B virus core particles induces a strong and highly cross-reactive antibody response in mice
    • doi:10.1016/j.virol.2004.02.022
    • Geldmacher, A. et al. 2004 An amino-terminal segment of hantavirus nucleocapsid protein presented on hepatitis B virus core particles induces a strong and highly cross-reactive antibody response in mice. Virology 323, 108-119. (doi:10.1016/j.virol.2004.02.022)
    • (2004) Virology , vol.323 , pp. 108-119
    • Geldmacher, A.1
  • 21
    • 0029950091 scopus 로고    scopus 로고
    • Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis
    • Gerelsaikhan, T., Tavis, J. E. & Bruss, V. 1996 Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis. J. Virol. 70, 4269-4274.
    • (1996) J. Virol , vol.70 , pp. 4269-4274
    • Gerelsaikhan, T.1    Tavis, J.E.2    Bruss, V.3
  • 22
    • 0344585939 scopus 로고    scopus 로고
    • Anti-virals interacting with hepatitis B virus core protein and core mutations may misdirect capsid assembly in a similar fashion
    • doi:10.1016/j.bcp.2003.08.001
    • Hacker, H. J., Deres, K., Mildenberger, M. & Schroder, C. H. 2003 Anti-virals interacting with hepatitis B virus core protein and core mutations may misdirect capsid assembly in a similar fashion. Biochem. Pharmacol. 66, 2273-2279. (doi:10.1016/j.bcp.2003.08.001)
    • (2003) Biochem. Pharmacol , vol.66 , pp. 2273-2279
    • Hacker, H.J.1    Deres, K.2    Mildenberger, M.3    Schroder, C.H.4
  • 23
    • 45249083395 scopus 로고
    • The Leeuwenhoek lecture, 1988. Antoni van Leeuwenhoek 1632-1723
    • doi:10.1098/rsnr.1989.0017
    • Hall, A. R. 1989 The Leeuwenhoek lecture, 1988. Antoni van Leeuwenhoek 1632-1723. Notes Rec. R. Soc. Lond. 43, 249-273. (doi:10.1098/rsnr.1989.0017)
    • (1989) Notes Rec. R. Soc. Lond , vol.43 , pp. 249-273
    • Hall, A.R.1
  • 24
    • 3142655417 scopus 로고    scopus 로고
    • Realizing the potential of electron cryomicroscopy
    • doi:10.1017/S0033583504003920
    • Henderson, R. 2004 Realizing the potential of electron cryomicroscopy. Q. Rev. Biophys. 37, 3-13. (doi:10.1017/S0033583504003920)
    • (2004) Q. Rev. Biophys , vol.37 , pp. 3-13
    • Henderson, R.1
  • 25
    • 0036284808 scopus 로고    scopus 로고
    • Influence of a putative intermolecular interaction between core and the pre-S1 domain of the large envelope protein on hepatitis B virus secretion
    • doi:10.1128/JVI.76.13.6510-6517.2002
    • Le Pogam, S. & Shih, C. 2002 Influence of a putative intermolecular interaction between core and the pre-S1 domain of the large envelope protein on hepatitis B virus secretion. J. Virol. 76, 6510-6517. (doi:10.1128/JVI.76.13.6510-6517.2002)
    • (2002) J. Virol , vol.76 , pp. 6510-6517
    • Le Pogam, S.1    Shih, C.2
  • 26
    • 0033808521 scopus 로고    scopus 로고
    • Low-level secretion of human hepatitis B virus virions caused by two independent, naturally occurring mutations (P5T and L60V) in the capsid protein
    • doi:10.1128/JVI.74.19.9099-9105.2000
    • Le Pogam, S., Yuan, T. T.-T., Sahu, G. H., Chatterjee, S. & Shih, C. 2000 Low-level secretion of human hepatitis B virus virions caused by two independent, naturally occurring mutations (P5T and L60V) in the capsid protein. J. Virol. 74, 9099-9105. (doi:10.1128/JVI.74.19.9099-9105.2000)
    • (2000) J. Virol , vol.74 , pp. 9099-9105
    • Le Pogam, S.1    Yuan, T.T.-T.2    Sahu, G.H.3    Chatterjee, S.4    Shih, C.5
  • 27
    • 0023662784 scopus 로고
    • The Leeuwenhoek lecture, 1985. A molecular biologist's view of viral hepatitis
    • doi:10.1098/rspb.1987.0013
    • Murray, K. 1987 The Leeuwenhoek lecture, 1985. A molecular biologist's view of viral hepatitis. Proc. R. Soc. B 230, 107-146. (doi:10.1098/rspb.1987.0013)
    • (1987) Proc. R. Soc. B , vol.230 , pp. 107-146
    • Murray, K.1
  • 28
    • 10044242868 scopus 로고    scopus 로고
    • Nucleolar localization of human hepatitis B virus capsid protein
    • doi:10.1128/JVI.78.24.13653-13668.2004
    • Ning, B. & Shih, C. 2004 Nucleolar localization of human hepatitis B virus capsid protein. J. Virol. 78, 13 653-13 668. (doi:10.1128/JVI.78.24.13653-13668.2004)
    • (2004) J. Virol , vol.78
    • Ning, B.1    Shih, C.2
  • 29
    • 21144480904 scopus 로고    scopus 로고
    • Safety and enhanced immunogenicity of a hepatitis B core particle Plasmodium falciparum malaria vaccine formulated in adjuvant Montanide ISA 720 in a phase I trial
    • doi:10.1128/IAI.73.6.3587-3597.2005
    • Oliveira, G. A. et al. 2005 Safety and enhanced immunogenicity of a hepatitis B core particle Plasmodium falciparum malaria vaccine formulated in adjuvant Montanide ISA 720 in a phase I trial. Infect. Immun. 73, 3587-3597. (doi:10.1128/IAI.73.6.3587-3597.2005)
    • (2005) Infect. Immun , vol.73 , pp. 3587-3597
    • Oliveira, G.A.1
  • 30
    • 0037213251 scopus 로고    scopus 로고
    • Mapping of amino acid side chains on the surface of hepatitis B virus capsids required for envelopment and virion formation
    • doi:10.1128/JVI.77.1.416-422. 2003
    • Ponsel, D. & Bruss, V. 2003 Mapping of amino acid side chains on the surface of hepatitis B virus capsids required for envelopment and virion formation. J. Virol. 77, 416-422. (doi:10.1128/JVI.77.1.416-422. 2003)
    • (2003) J. Virol , vol.77 , pp. 416-422
    • Ponsel, D.1    Bruss, V.2
  • 31
    • 0034889864 scopus 로고    scopus 로고
    • HBV core particles as a carrier for B cell/T cell epitopes
    • doi:10.1159/000050037
    • Pumpens, P. & Grens, E. 2001 HBV core particles as a carrier for B cell/T cell epitopes. Intervirology 44, 98-114. (doi:10.1159/000050037)
    • (2001) Intervirology , vol.44 , pp. 98-114
    • Pumpens, P.1    Grens, E.2
  • 34
    • 33745223883 scopus 로고    scopus 로고
    • Hepatitis B virus capsid-like particles can display the complete, dimeric outer surface protein C and stimulate production of protective antibody responses against Borrelia burgdorferi infection
    • doi:10.1074/jbc.M513571200
    • Skamel, C., Ploss, M., Böttcher, B., Stehle, T., Wallich, R., Simon, M. M. & Nassal, M. 2006 Hepatitis B virus capsid-like particles can display the complete, dimeric outer surface protein C and stimulate production of protective antibody responses against Borrelia burgdorferi infection. J. Biol. Chem. 281, 17474-17481. (doi:10.1074/jbc.M513571200)
    • (2006) J. Biol. Chem , vol.281 , pp. 17474-17481
    • Skamel, C.1    Ploss, M.2    Böttcher, B.3    Stehle, T.4    Wallich, R.5    Simon, M.M.6    Nassal, M.7
  • 35
    • 0035909370 scopus 로고    scopus 로고
    • The bacteriophage φ29 portal motor can package DNA against a large internal force
    • doi:10.1038/35099581
    • Smith, D. E., Tans, S. J., Smith, S. B., Grimes, S., Anderson, D. L. & Bustamante, C. 2001 The bacteriophage φ29 portal motor can package DNA against a large internal force. Nature 413, 748-752. (doi:10.1038/35099581)
    • (2001) Nature , vol.413 , pp. 748-752
    • Smith, D.E.1    Tans, S.J.2    Smith, S.B.3    Grimes, S.4    Anderson, D.L.5    Bustamante, C.6
  • 37
    • 0019949367 scopus 로고
    • Replication of the genome of a hepatitis-B-like virus by reverse transcription of an RNA intermediate
    • doi:10.1016/0092-8674(82)90157-X
    • Summers, J. & Mason, W. S. 1982 Replication of the genome of a hepatitis-B-like virus by reverse transcription of an RNA intermediate. Cell 29, 403-415. (doi:10.1016/0092-8674(82)90157-X)
    • (1982) Cell , vol.29 , pp. 403-415
    • Summers, J.1    Mason, W.S.2
  • 38
    • 0033152857 scopus 로고    scopus 로고
    • The crystal structure of the human hepatitis B virus capsid
    • doi:10.1016/S1097-2765(01)80009-5
    • Wynne, S. A., Crowther, R. A. & Leslie, A. G. W. 1999 The crystal structure of the human hepatitis B virus capsid. Mol. Cell 3, 771-780. (doi:10.1016/S1097-2765(01)80009-5)
    • (1999) Mol. Cell , vol.3 , pp. 771-780
    • Wynne, S.A.1    Crowther, R.A.2    Leslie, A.G.W.3
  • 39
    • 0141834247 scopus 로고    scopus 로고
    • Subtype-independent immature secretion and subtype-dependent replication deficiency of a highly frequent, naturally occurring mutation of human hepatitis B virus core antigen
    • Yuan, T. T.-T., Tai, P.-C. & Shih, C. 1999 Subtype-independent immature secretion and subtype-dependent replication deficiency of a highly frequent, naturally occurring mutation of human hepatitis B virus core antigen. J. Virol. 73, 10 122-10 128.
    • (1999) J. Virol , vol.73
    • Yuan, T.T.-T.1    Tai, P.-C.2    Shih, C.3


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