Reduced lung function in a chronic asthma model is associated with prolonged inflammation, but independent of peribronchial fibrosis

PLoS ONE

Volumn 3, Issue 2, 2008, Pages

  Koerner Rettberg, Cordula ^a   Doths, Sandra ^a   Stroet, Anke ^a   Schwarze, Jürgen ^a,b  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CYTOKINE; IMMUNOGLOBULIN G2A ANTIBODY; INTERLEUKIN 13; INTERLEUKIN 5; OVALBUMIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; ASTHMA; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; EOSINOPHILIA; FEMALE; HISTOPATHOLOGY; IMMUNE RESPONSE; LONG TERM EXPOSURE; LUNG FIBROSIS; LUNG FUNCTION TEST; LUNG LAVAGE; LYMPHOCYTOSIS; MOUSE; NONHUMAN; SENSITIZATION; T LYMPHOCYTE; TH1 CELL; ANIMAL; BIOSYNTHESIS; CHRONIC DISEASE; FIBROSIS; IMMUNOLOGY; INFLAMMATION; LUNG; PATHOLOGY; PATHOPHYSIOLOGY;

MUS;

ALLERGENS; ANIMALS; ASTHMA; CHRONIC DISEASE; FIBROSIS; INFLAMMATION; INTERLEUKIN-5; LUNG; LYMPHOCYTOSIS; MICE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 45249107798     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001575     Document Type: Article

References (38)

1. (1998) Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 351: 1225-1232.
2. Kumar RK, Foster PS (2002) Modeling allergic asthma in mice: pitfalls and opportunities. Am J Respir Cell Mol Biol 27: 267-272.
3. Roche WR, Beasley R, Williams JH, Holgate-ST (1989) Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1: 520-524.
4. Bento AM, Hershenson MB (1998) Airway remodeling: potential contributions of subepithelial fibrosis and airway smooth muscle hypertrophy/hyperplasia to airway narrowing in asthma. Allergy Asthma Proc 19: 353-358.
5. Leigh R, Ellis R, Wattie J, Southam DS, De Hoogh M, et al. (2002) Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation. Am J Respir Cell Mol Biol 27: 526-535.
6. Jain VV, Kitagaki K, Businga T, Hussain I, George C, et al. (2002) CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma. J Allergy Clin Immunol 110: 867-872.
7. Temelkovski J, Hogan SP, Shepherd DP, Foster PS, Kumar RK (1998) An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen. Thorax 53: 849-856.
8. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, et al. (2004) Inhibition of airway remodeling in IL-5-deficient mice. J Clin Invest 113: 551-560.
9. McMillan SJ, Lloyd CM (2004) Prolonged allergen challenge in mice leads to persistent airway remodelling. Clin Exp Allergy 34: 497-507.
10. Henderson WR Jr, Tang LO, Chu SJ, Tsao SM, Chiang GY, et al. (2002) A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med 165: 108-116.
11. Shinagawa K, Kojima M (2003) Mouse model of airway remodeling: strain differences. Am J Respir Crit Care Med 168: 959-967.
12. Corbel M, Caulet-Maugendre S, Germain N, Lagente V, Boichot E (2003) Enhancement of gelatinase activity during development of subepithelial fibrosis in a murine model of asthma. Clin Exp Allergy 33: 696-704.
13. Wegmann M, Fehrenbach H, Fehrenbach A, Held T, Schramm C, et al. (2005) Involvement of distal airways in a chronic model of experimental asthma. Clin Exp Allergy 35: 1263-1271.
14. Locke NR, Royce SG, Wainewright JS, Samuel CS, Tang ML (2007) Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease. Am J Respir Cell Mol Biol 36: 625-632.
15. Renauld JC (2001) New insights into the role of cytokines in asthma. J Clin Pathol 54: 577-589.
16. Hamelmann E, Wahn U, Gelfand EW (1999) Role of the Th2 cytokines in the development of allergen-induced airway inflammation and hyperresponsiveness. Int Arch Allergy Immunol 118: 90-94.
17. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, et al. (1998) Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282: 2261-2263.
18. Leigh R, Ellis R, Wattie JN, Hirota JA, Matthaei KI, et al. (2004) Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice. Am J Respir Crit Care Med 169: 860-867.
19. Kumar RK, Herbert C, Yang M, Koskinen AM, McKenzie AN, et al. (2002) Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma. Clin Exp Allergy 32: 1104-1111.
20. Werfel T, Morita A, Grewe M, Renz H, Wahn U, et al. (1996) Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis. J Invest Dermatol 107: 871-876.
21. Corrigan CJ, Kay AB (1990) CD4 T-lymphocyte activation in acute severe asthma. American Review of Respiratory Diseases 141: 970-977.
22. Cembrzynska-Nowak M, Szklarz E, Inglot AD, Teodrczyk-Injeyan JA (1993) Elevated release of tumor necrosis factor- alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma. American Review of Respiratory Diseases 147: 291-295.
23. Hamelmann E, Schwarze J, Takeda K, Oshiba A, Larsen GL, et al. (1997) Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 156: 766-775.
24. Cieslewicz G, Tomkinson A, Adler A, Duez C, Schwarze J, et al. (1999) The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration. Journal of Clinical Investigation 104: 301.
25. Leigh R, Southam DS, Ellis R, Wattie JN, Sehmi R, et al. (2004) T-cell-mediated inflammation does not contribute to the maintenance of airway dysfunction in mice. J Appl Physiol 97: 2258-2265.
26. Wardlaw AJ, Dunnette S, Gleich GJ, Collins JV, Kay AB (1988) Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis 137: 62-69.
27. Brusasco V, Crimi E, Gianiorio P, Lantero S, Rossi GA (1990) Allergen-induced increase in airway responsiveness and inflammation in mild asthma. J Appl Physiol 69: 2209-2214.
28. Hamelmann E, Gelfand EW (2001) IL-5-induced airway eosinophilia-the key to asthma? Immunol Rev 179: 182-191.
29. Johnson JR, Wiley RE, Fattouh R, Swirski FK, Gajewska BU, et al. (2004) Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling. Am J Respir Crit Care Med 169: 378-385.
30. Leigh R, Ellis R, Wattie J, Donaldson DD, Inman MD (2004) Is interleukin-13 critical in maintaining airway hyperresponsiveness in allergen-challenged mice? Am J Respir Crit Care Med 170:851-856.
31. Kumar RK, Herbert C, Webb DC, Li L, Foster PS (2004) Effects of anticytokine therapy in a mouse model of chronic asthma. Am J Respir Crit Care Med 170: 1043-1048.
32. Hansen G, Berry G, DeKruyff RH, Umetsu DT (1999) Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. Journal of Clinical Investigation 103: 175.
33. Hansen G, McIntire JJ, Yeung VP, Berry G, Thorbecke GJ, et al. (2000) CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation. J Clin Invest 105: 61-70.
34. Branton MH, Kopp JB (1999) TGF-beta and fibrosis. Microbes Infect 1: 1349-1365.
35. Minshall E, Leung D, Martin R, Song Y, Cameron I, et al. (1997) Eosinophil-associated TGF-beta 1 mRNA expression and fibrosis in bronchial asthma. American Journal of Respiratory Cell and Molecular Biology 17: 326.
36. Vignola AM, Chanez P, Chiappara G, Merendino A, Pace E, et al. (1997) Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 156: 591-599.
37. Kovacs EJ, DiPietro LA (1994) Fibrogenic cytokines and connective tissue production. Faseb J 8: 854-861.
38. Richter A, Puddicombe SM, Lordan JL, Bucchieri F, Wilson SJ, et al. (2001) The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol 25: 385-391.