Your pain or mine? Common and distinct neural systems supporting the perception of pain in self and other

Social Cognitive and Affective Neuroscience

Volumn 3, Issue 2, 2008, Pages 144-160

  Ochsner, Kevin N ^a   Zaki, Jamil ^a   Hanelin, Josh ^b   Ludlow, David H ^c   Knierim, Kyle ^c   Ramachandran, Tara ^c   Glover, Gary H ^c   Mackey, Sean C ^c  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Stanford University ^*  (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Anterior cingulate; Anterior insula; Emotion; Empathy; Pain; Self

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; ANXIETY; ARTICLE; BRAIN REGION; CINGULATE GYRUS; CONTROLLED STUDY; EMOTION; EMPATHY; FEMALE; FRONTAL LOBE; HEAT; HUMAN; HUMAN EXPERIMENT; INJURY; INSULA; LEARNING; MALE; NERVOUS SYSTEM; NEUROPHYSIOLOGICAL RECRUITMENT; NOCICEPTION; NORMAL HUMAN; PARIETAL LOBE; PREFRONTAL CORTEX; PREMOTOR CORTEX; PRIORITY JOURNAL; TASK PERFORMANCE; THEORY; VIDEORECORDING;

ADULT; ANXIETY; CEREBRAL CORTEX; EMPATHY; FEAR; FEMALE; HUMANS; INTERNAL-EXTERNAL CONTROL; MALE; NEURAL PATHWAYS; PAIN; REFERENCE VALUES; SELF ASSESSMENT (PSYCHOLOGY); SELF CONCEPT; SOCIAL PERCEPTION; YOUNG ADULT;

EID: 45149123445     PISSN: 17495016     EISSN: 17495024     Source Type: Journal    
DOI: 10.1093/scan/nsn006     Document Type: Article

References (121)

1. Adolphs, R. (2003). Cognitive neuroscience of human social behaviour. Nature Reviews Neuroscience, 4, 165-78.
2. Allison, T., Puce, A., McCarthy, G. (2000). Social perception from visual cues: Role of the STS region. Trends in Cognitive Sciences, 4 267-78.
3. Anderson, A.K., Christoff, K., Panitz, D., De Rosa, E., Gabrieli, J.D. (2003). Neural correlates of the automatic processing of threat facial signals. Journal of Neuroscience, 23, 5627-33.
4. Anderson, A.K., Phelps, E.A. (2001). Lesions of the human amygdala impair enhanced perception of emotionally salient events. Nature, 411 305-9.
5. Baron-Cohen, S., Knickmeyer, R.C., Belmonte, M.K. (2005). Sex differences in the brain: Implications for explaining autism. Science, 310, 819-23.
6. Becerra, L.R., Breiter, H.C., Stojanovic, M., et al. (1999). Human brain activation under controlled thermal stimulation and habituation to noxious heat: An IMRI study. Magnetic Resonance in Medicine, 41, 1044-57.
7. Bechara, A. (2002). The neurology of social cognition. Brain, 125, 1673-5.
8. Bechara, A., Damasio, H., Damasio, A.R. (2003). Role of the amygdala in decision-making. Annals of the New York Academy of Sciences, 985, 356-69.
9. Beer, J.S., Heerey, E.A., Keltner, D., Scabini, D., Knight, R.T. (2003). The regulatory function of self-conscious emotion: Insights from patients with orbitofrontal damage. Journal of Personality and Social Psychology, 85, 594-604.
10. Beer, J.S., Ochsner, K.N. (2006). Social cognition: A multi level analysis. Brain Research, 1079, 98-105.
11. Beer, J.S., Shimamura, A.P., Knight, R.T. (2004). Frontal lobe contributions to executive control of cognitive and social behavior. In: Gazzaniga, M.S., editor. The Cognitive Neurosciences: III, Cambridge, MA: MIT Press, pp. 1091-104.
12. Blair, R.J. (2003). Neurobiological basis of psychopathy. British Journal of Psychiatry, 182, 5-7.
13. Blais, M.A., Otto, M.W., Zucker, B.G., et al. (2001). The anxiety sensitivity index: Item analysis and suggestions for refinement. Journal of Personality Assessment, 77, 272-94.
14. Blakemore, S.J., Decety, J. (2001). From the perception of action to the understanding of intention. Nature Review Neuroscience, 2, 561-7.
15. Botvinick, M., Jha, A.P., Bylsma, L.M., et al. (2005). Viewing facial expressions of pain engages cortical areas involved in the direct experience of pain. Neuroimage, 25, 312 9.
16. Botvinick, M.M., Braver, T.S., Barch, D.M., Carter, C.S., Cohen, J.D. (2001). Conflict monitoring and cognitive control. Psychological Review, 108, 624-52.
17. Botvinick, M.M., Cohen, J.D., Carter, C.S. (2004). Conflict monitoring and anterior cingulate cortex: An update. Trends in Cognitive Sciences, 8, 539-46.
18. Bunge, S.A., Ochsner, K.N., Desmond, J.E., Glover, G.H., Gabrieli, J.D. (2001). Prefrontal regions involved in keeping information in and out of mind. Brain, 124, 2074-86.
19. Calder, A.J., Lawrence, A.D., Young, A.W. (2001). Neuropsychology of fear and loathing. Nature Review Neuroscience, 2, 352-63.
20. Carr, L., Iacoboni, M., Dubeau, M.C., Mazziotta, J.C., Lenzi, G.L. (2003). Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas. Proceedings of the National Academy of Sciences of the United States of America, 100, 5497-502.
21. Cavanna, A.E., Trimble, M.R. (2006). The precuneus: A review of its functional anatomy and behavioural correlates. Brain, 129, 564-83.
22. Chaminade, T., Meltzoff, A.N., Decety, J. (2005). An fMRI study of imitation: Action representation and body schema. Neuropsychologia, 43, 115-27.
23. Christoff, K., Gabrieli, J.D.E. (2000). The frontopolar cortex and human cognition: Evidence for a rostrocaudal hierarchical organization in human prefrontal cortex. Psychobiology, 28, 168-86.
24. Christoff, K., Ream, J.M., Geddes, L.P., Gabrieli, J.D. (2003). Evaluating self generated information: Anterior prefrontal contributions to human cognition. Behavioral Neurosciences, 117, 1161-8.
25. Coghill, R.C., McHaffie, J.G., Yen, Y.F. (2003). Neural correlates of interindividual differences in the subjective experience of pain. Proceedings of the National Academy of Sciences of the United States of America, 100, 8538-42.
26. Craig, A.D. (2002). How do you feel? Interoception: The sense of the physiological condition of the body. Nature Reviews Neuroscience, 3 655-66.
27. Craig, A.D. (2003). Interoception: The sense of the physiological condition of the body. Current Opinion in Neurobiology, 13, 500-05.
28. Craig, A.D. (2004). Human feelings: Why are some more aware than others? Trends in Cognitive Sciences, 8, 239-41.
29. Critchley, H.D. (2005). Neural mechanisms of autonomic, affective, and cognitive integration. The Journal of Comparative Neurology, 493, 154-66.
30. Curtis, C.E., Sun, F.T., Miller, L.M., D'Esposito, M. (2005). Coherence between MRI time-series distinguishes two spatial working memory networks. Neuroimage, 26, 177-83.
31. Dapretto, M., Davies, M.S., Pfeifer, J.H., et al. (2006). Understanding emotions in others: Mirror neuron dysfunction in children with autism spectrum disorders. Nature Neuroscience, 9, 28-30.
32. Davidson, R.J. (2002). Anxiety and affective style: Role of prefrontal cortex and amygdala. Biological Psychiatry, 51, 68-80.
33. Davis, K.D., Taylor, S.J., Crawley, A.P., Wood, M.L., Mikulis, D.J. (1997). Functional MRI of pain- and attention-related activations in the human cingulate cortex. Journal of Neurophysiology, 77, 3370-80.
34. Decety, J., Chaminade, T., Grezes, J., Meltzoff, A.N. (2002). A PET exploration of the neural mechanisms involved in reciprocal imitation. Neuroimage, 15, 265-72.
35. Decety, J., Jackson, P.L. (2004). The functional architecture of human empathy. Behavioral and Cognitive Neuroscience Reviews, 3, 71-100.
36. Delgado, M.R., Olsson, A., Phelps, E.A. (2006). Extending animal models of fear conditioning to humans. Biological Psychology, 73, 39-48.
37. Derbyshire, S.W., Vogt, B.A., Jones, A.K. (1998). Pain and Stroop interference tasks activate separate processing modules in anterior cingulate cortex. Experimental Brain Research, 118, 52-60.
38. Devinsky, O., Morrell, M.J., Vogt, B.A. (1995). Contributions of anterior cingulate cortex to behaviour. Brain, 118, 279-306.
39. Downar, J., Crawley, A.P., Mikulis, D.J., Davis, K.D. (2002). A cortical network sensitive to stimulus salience in a neutral behavioral context across multiple sensory modalities. Journal of Neurophysiology, 87 615-20.
40. Downar, J., Mikulis, D.J., Davis, K.D. (2003). Neural correlates of the prolonged salience of painful stimulation. Neuroimage, 20, 1540-51.
41. Eisenberger, N.I., Lieberman, M.D. (2004). Why rejection hurts: A common neural alarm system for physical and social pain. Trends in Cognitive Sciences, 8, 294-300.
42. Etkin, A., Klemenhagen, K.C., Dudman, J.T., et al. (2004). Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful faces. Neuron, 44, 1043-55.
43. Fan, J., Flombaum, J.I., McCandliss, B.D., Thomas, K.M., Posner, M.I. (2003). Cognitive and brain consequences of conflict. Neuroimage, 18 42-57.
44. Farrell, M.J., Laird, A.R., Egan, G.F. (2005). Brain activity associated with painfully hot stimuli applied to the upper limb: A meta-analysis. Human Brain Mapping, 25, 129-39.
45. Farrer, C., Franck, N., Georgieff, N., Frith, C.D., Decety, J., Jeannerod, M. (2003). Modulating the experience of agency: A positron emission tomography study. Neuroimage, 18, 324-33.
46. Farrow, T.F., Zheng, Y., Wilkinson, I.D., et al. (2001). Investigating the functional anatomy of empathy and forgiveness. Neuroreport, 12 2433-8.
47. Fredrickson, B.L., Kahneman, D. (1993). Duration neglect in retrospective evaluations of affective episodes. Journal of Personality and Social Psychology, 65, 45-55.
48. Frith, U. (2001). Mind blindness and the brain in autism. Neuron, 32 969-79.
49. Gallagher, H.L., Frith, C.D. (2003). Functional imaging of 'theory of mind'. Trends in Cognitive Sciences, 7, 77-83.
50. Gallese, V., Keysers, C., Rizzolatti, G. (2004). A unifying view of the basis of social cognition. Trends in Cognitive Sciences, 8, 396-403.
51. Glover, G. (1999). 3D Z-shim method for reduction of susceptibility effects in BOLD fMRI. Magnetic Resonance in Medicine, 42, 290-9.
52. Goel, V., Dolan, R.J. (2003). Reciprocal neural response within lateral and ventral medial prefrontal cortex during hot and cold reasoning. Neuroimage, 20, 2314-21.
53. Hebben, N. (1985). Toward the assessment of clinical pain. In: Aronoff, G.M., editor. Evaluation and Treatment of Chronic Pain. Baltimore: Urban & Schwarzenburg, pp. 451-62.
54. Hornak, J., Bramham, J., Rolls, E.T., et al. (2003). Changes in emotion after circumscribed surgical lesions of the orbitoftontal and cingulate cortices. Brain, 126, 1691-712.
55. Hutchison, W.D., Davis, K.D., Lozano, A.M., Tasker, R.R., Dostrovsky, J.O. (1999). Pain-related neurons in the human cingulate cortex. Nature Neuroscience, 2, 403-5.
56. Hynes, C.A., Baird, A.A., Grafton, S.T. (2006). Differential role of the orbital frontal lobe in emotional versus cognitive perspective-taking. Neuropsychologia, 44, 374-83.
57. Iacoboni, M. (2005). Neural mechanisms of imitation. Current Opinion in Neurobiology, 15, 632-7.
58. Ickes, W.J. (1997). Empathic accuracy. Guilford Press, NY, 1997.
59. Jackson, P.L., Brunet, E., Meltzoff, A.N., Decety, J. (2006a). Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain. Neuropsychologia, 44, 752-61.
60. Jackson, P.L., Meltzoff, A.N., Decety, J. (2005). How do we perceive the pain of others? A window into the neural processes involved in empathy. Neuroimage, 24, 771-9.
61. Jackson, P.L., Rainville, P., Decety, J. (2006b). To what extent do we share the pain of others? Insight from the neural bases of pain empathy. Pain, 125, 5-9.
62. Kampe, K.K., Frith, C.D., Frith, U. (2003). "Hey John": Signals conveying communicative intention toward the self activate brain regions associated with "mentalizing," regardless of modality. Journal of Neuroscience, 23, 5258-63.
63. Keysers, C., Perrett, D.I. (2004). Demystifying social cognition: A Hebbian perspective. Trends in Cognitive Sciences, 8, 501-7.
64. Krolak-Salmon, P., Henaff, M.A., Isnard, J., et al. (2003). An attention modulated response to disgust in human ventral anterior insula. Annals of Neurology, 53, 446-53.
65. Lamm, C., Batson, C.D., Decety, J. (2007). The neural substrate of human empathy: Effects of perspective-taking and cognitive appraisal. Journal of Cognitive Neuroscience, 19, 42-58.
66. Levine, L.J., Safer, M.A. (2002). Sources of bias in memory for emotions. Current Directions in Psychological Science, 11, 169-73.
67. Lou, H.C., Luber, B., Crupain, M., et al. (2004). Parietal cortex and representation of the mental Self. Proceedings of the National Academy of Sciences ofthe United States ofAmerica, 101, 6827-32.
68. McNeil, D.W., Rainwater, A.J. 3rd. (1998). Development of the fear of pain questionnaire-III. Journal of Behavioral Medicine, 21, 389-410.
69. Meltzoff, AX, Decety, J. (2003). What imitation tells us about social cognition: A rapprochement between developmental psychology and cognitive neuroscience. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 358, 491-500.
70. Mesulam, M.M., Mufson, E.J. (1982). Insula of the old world monkey. III: efferent cortical output and comments on function. Journal of Comparative Neurology, 212, 38-52.
71. Milham, M.P., Banich, M.T., Webb, A., et al. (2001). The relative involvement of anterior cingulate and prefrontal cortex in attentional control depends on nature of conflict. Brain Research Cognitive Brain Research, 12, 467-73.
72. Mitchell, J.P. (2006). Mentalizing and Marr: An information processing approach to the study of social cognition. Brain Research, 1079, 66-75.
73. Mitchell, J.P., Banaji, M.R., Macrae, C.N. (2005). The link between social cognition and self-referential thought in the medial prefrontal cortex. Journal of Cognitive Neuroscience, 17, 1306-15.
74. Mitchell, J.P., Heatherton, T.F., Macrae, C.N. (2002). Distinct neural systems subserve person and object knowledge. Proceedings of the National Academy of Sciences of the United States of America, 99, 15238-43.
75. Morrison, I., Downing, P.E. (2007). Organization of felt and seen pain responses in anterior cingulate cortex. Neuroimage, 37, 642-51.
76. Morrison, I., Lloyd, D., di Pellegrino, G., Roberts, N. (2004). Vicarious responses to pain in anterior cingulate cortex: Is empathy a multisensory issue? Cognitive, Affective and Behavioral Neuroscience, 4, 270-8.
77. Morrison, I., Peelen, M.V., Downing, P.E. (2007). The sight of others' pain modulates motor processing in human cingulate cortex. Cerebral Cortex, 17, 2214-22.
78. Mufson, E.J., Mesulam, M.M. (1982). Insula of the old world monkey. II: afferent cortical input and comments on the claustrum. Journal of Comparative Neurology, 212, 23-37.
79. O'Doherty, J., Critchley, H., Deichmann, R., Dolan, R.J. (2003). Dissociating valence of outcome from behavioral control in human orbital and ventral prefrontal cortices. Journal of Neuroscience, 23, 7931-9.
80. O'Doherty, J.P. (2004). Reward representations and reward-related learning in the human brain: Insights from neuroimaging. Current Opinion in Neurobiology, 14, 769-76.
81. Ochsner, K.N. (2000). Are affective events richly recollected or simply familiar? The experience and process of recognizing feelings past. Journal of Experimental Psychological. General, 129, 242-61.
82. Ochsner, K.N., Beer, J.S., Robertson, E., et al. (2005). The neural correlates of direct and reflected self knowledge. Neuroimage, 28, 797-814.
83. Ochsner, K.N., Knierim, K., Ludlow, D., Hanelin, J., Ramachandran, T., Mackey, S. (2004). Reflecting upon feelings: An fMRI study of neural systems supporting the attribution of emotion to self and other. Journal of Cognitive Neuroscience, 16, 1746-72.
84. Ochsner, K.N., Kosslyn, S.M., Cosgrove, G.R., et al. (2001). Deficits in visual cognition and attention following bilateral anterior cingulotomy. Neuropsychologia, 39, 219-30.
85. Ochsner, K.N., Ludlow, D.H., Knierim, K., et al. (2006). Neural correlates of individual differences in pain-related fear and anxiety. Pain, 120, 69-77.
86. Ochsner, K.N., Schacter, D.L. (2000). A social cognitive neuroscience approach to emotion and memory. In: Borod, J.C., editor. The Neuropsychology of Emotion. London: Oxford University Press, pp. 163-93.
87. Olsson, A., Nearing, K.I., Phelps, E.A. (2007). Learning Fears by Observing Others: The Neural Systems of Social Fear Transmission. Social Cognitive and Affective Neuroscience, 2, 3-11.
88. Olsson, A., Phelps, E.A. (2004). Learned fear of "unseen" faces after Pavlovian, observational, and instructed fear. Psychological Science, 15, 822-8.
89. Peyron, R., Laurent, B., Garcia-Larrea, L. (2000). Functional imaging of brain responses to pain. A review and meta-analysis. Neurophysiologie Clinique, 30, 263-88.
90. Phan, K.L., Wager, T., Taylor, S.F., Liberzon, I. (2002). Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI. Neuroimage, 16, 331-48.
91. Phelps, E.A., Anderson, A.K. (1997). Emotional memory: What does the amygdala do? Current Biology, 7, R311-4.
92. Phillips, M.L., Young, A.W., Senior, C., et al. (1997). A specific neural substrate for perceiving facial expressions of disgust. Nature, 389, 495-8.
93. Postle, B.R., Awh, E., Jonides, J., Smith, E.E., D'Esposito, M. (2004). The where and how of attention-based rehearsal in spatial working memory. Brain Research Cognitive Brain Research, 20, 194-205.
94. Preston, A.R., Thomason, M.E., Ochsner, K.N., Cooper, J.C., Glover, G.H. (2004). Comparison of spiral-in/out and spiral-out BOLD fMRI at 1.5 and 3T. Neuroimage, 21, 291-301.
95. Putman, P., Hermans, E., van Honk, J. (2006). Anxiety meets fear in perception of dynamic expressive gaze. Emotion, 6, 94-102.
96. Raij, T.T., Numminen, J., Narvanen, S., Hiltunen, J., Hari, R. (2005). Brain correlates of subjective reality of physically and psychologically induced pain. Proceedings of the National Academy of Sciences of the United States of America, 102, 2147-51.
97. Rainville, P., Doucet, J.C., Fortin, M.C., Duncan, G.H. (2004). Rapid deterioration of pain sensory-discriminative information in short-term memory. Pain, 110, 605-15.
98. Rainville, P., Duncan, G.H., Price, D.D., Carrier, B., Bushnell, M.C. (1997). Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science, 277, 968-71.
99. Ranganath, C., Johnson, M.K., D'Esposito, M. (2003). Prefrontal activity associated with working memory and episodic long-term memory. Neuropsychologia, 41, 378-89.
100. Ruby, P., Decety, J. (2004). How would you feel versus how do you think she would feel? A neuroimaging study of perspective-taking with social emotions. Journal of Cognitive Neuroscience, 16, 988-99.
101. Saarela, M.V., Hlushchuk, Y., Williams, A.C., Schurmann, M., Kalso, E., Hari, R. (2007). The compassionate brain: Humans detect intensity of pain from another's face. Cerebral Cortex, 17, 230-7.
102. Sawamoto, N., Honda, M., Okada, T., et al. (2000). Expectation of pain enhances responses to nonpainful somatosensory stimulation in the anterior cingulate cortex and parietal operculum/posterior insula: An event-related functional magnetic resonance imaging study. Journal of Neuroscience, 20, 7438-45.
103. Schoenbaum, G., Setlow, B., Saddoris, M.P., Gallagher, M. (2003). Encoding predicted outcome and acquired value in orbitofrontal cortex during cue sampling depends upon input from basolateral amygdala. Neuron, 39, 855-67.
104. Seminowicz, D.A., Davis, K.D. (2006). Cortical responses to pain in healthy individuals depends on pain catastrophizing. Pain, 120, 297-306.
105. Shamay-Tsoory, S.G., Lester, H., Chisin, R., et al. (2005). The neural correlates of understanding the other's distress: A positron emission tomography investigation of accurate empathy. Neuroimage, 27, 468-72.
106. Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R.J., Frith, C.D. (2004). Empathy for pain involves the affective but not sensory components of pain. Science, 303, 1157-62.
107. Singer, T., Seymour, B., O'Doherty, J.P., Stephan, K.E., Dolan, R.J., Frith, C.D. (2006). Empathic neural responses are modulated by the perceived fairness of others. Nature, 439, 466-9.
108. Spielberger, C.D., Gorsuch, R.L., Lushemne, R., Vagg, P.R., Jacobs, G.A. (1983). Manual for the State-Trait Anxiety Inventory (Form Y). Palo Alto, CA: Consulting Psychologists Press.
109. Stone, V.E., Baron-Cohen, S., Knight, R.T. (1998). Frontal lobe contributions to theory of mind. Journal of Cognitive Neuroscience, 10, 640-56.
110. Sylvester, C.Y., Wager, T.D., Lacey, S.C., et al. (2003). Switching attention and resolving interference: FMRI measures of executive functions. Neuropsychologia, 41, 357-70.
111. Taylor, S.F., Phan, K.L., Decker, L.R., Liberzon, I. (2003). Subjective rating of emotionally salient stimuli modulates neural activity. Neuroimage, 18, 650-9.
112. Thompson-Schill, S.L., Jonides, J., Marshuetz, C., et al. (2002). Effects of frontal lobe damage on interference effects in working memory. Cognitive, Affective and Behavioral Neuroscience, 2, 109-20.
113. Vogeley, K., Fink, G.R. (2003). Neural correlates of the first-person-perspective. Trends in Cognitive Sciences, 7, 38-42.
114. Vogt, B.A. (2005). Pain and emotion interactions in subregions of the cingulate gyrus. Nature Reviews, Neuroscience, 6, 533-44.
115. Vollm, B.A., Taylor, A.N., Richardson, P., et al. (2006). Neuronal correlates of theory of mind and empathy: A functional magnetic resonance imaging study in a nonverbal task. Neuroimage, 29, 90-8.
116. Wager, T.D., Feldman Barrett, L. (2004). From affect to control: functional specialization of the insula in motivation and regulation. PsycExtra.
117. Wager, T.D., Jonides, J., Smith, E.E. (2005). Individual differences in multiple subtypes of switching attention. Cognitive, Affective and Behavioral Neuroscience, 5, 127-43.
118. Wager, T.D., Rilling, J.K., Smith, E.E., et al. (2004). Placebo-induced changes in FMRI in the anticipation and experience of pain. Science, 303, 1162-7.
119. Wicker, B., Keysers, C., Plailly, J., Royet, J.P., Gallese, V., Rizzolatti, G. (2003). Both of us disgusted in My insula: The common neural basis of seeing and feeling disgust. Neuron, 40, 655-64.
120. Wilson, E., MacLeod, C. (2003). Contrasting two accounts of anxiety-linked attentional bias: Selective attention to varying levels of stimulus threat intensity. Journal of Abnormal Psychology, 112, 212-8.
121. Zaki, J., Ochsner, K.N., Hanelin, J., Wager, T.D., Mackey, S. (2007). Different circuits for different pain: Patterns of functional connectivity reveal distinct networks for processing pain in self and others. Social Neuroscience, 2, 276-91.