Sweet potato storage root trypsin inhibitor and their peptic hydrolysates exhibited angiotensin converting enzyme inhibitory activity in vitro

Botanical Studies

Volumn 49, Issue 2, 2008, Pages 101-108

  Huang, Guan Jhong ^a   Ho, Yu Ling ^b   Chen, Hsien Jung ^c   Chang, Yuan Shiun ^a   Huang, Shyh Shyun ^a   Hung, Hsin Jung ^a   Lin, Yaw Huei ^d  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b HUNGKUANG UNIVERSITY   (Taiwan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^d INSTITUTE OF PLANT AND MICROBIAL BIOLOGY   (Taiwan)

Author keywords

Angiotensin converting enzyme (ACE); Pepsin; Sweet potato; Trypsin inhibitor

Indexed keywords

IPOMOEA BATATAS;

EID: 45149108218     PISSN: 1817406X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Anzenbacherova, E., P. Anzenbacher, K. Macek, and J. Kvetina. 2001. Determination of enzyme (angiotensin convertase) inhibitors based on enzymatic reaction followed by HPLC J. Pharm. Biomed. Anal. 24: 1151-1156.
2. Bellamy, W., R.H. Wakabayashi, M. Takase, K. Kawase, S. Shimamura, and M. Tomita. 1993. Role of cell-binding in the antibacterial mechanism of Lactoferricin B. J. Appl. Bacteriol. 75: 478-484.
3. Byun, H.G. and S.K. Kim. 2002. Structure and activity of angiotensin I converting enzyme inhibitory peptides derived from alaskan pollack skin. J. Biochem. Mol Biol. 35: 239-243.
4. Chen, T.L., Y.C. Lo, W.T. Hu, M.C. Wu, S.T. Chen, and H.M. Chang. 2003. Microencapsulation and modification of synthetic peptides of food proteins reduces the blood pressure of spontaneously hypertensive rats. J Agric. Food Chem. 51: 1671-1675.
5. Ehlers, M.R. and J.F. Riordan. 1989. Angiotensin-converting enzyme new concepts converting its biological role. Biochemistry 28: 5311-5317
6. Fiat, A.M., M.S. Daniele, and J. Pierre. 1993. Biological active peptides from milk proteins with emphasis on two examples concerning antithrombotic and immunomodulating activities. J. Dairy Sci. 76: 301-310.
7. Fujita, H., K. Yokoyama, and M. Yoshikawa. 2000. Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. J. Food Sci. 65: 564-569.
8. Holmquist, B., P. Bunning, and J.F. Riordan. 1979. A continuous spectrophotometric assay for angiotensin converting enzyme. Anal. Biochem. 95: 540-548.
9. Hou, W.C. and Y.H. Lin. 1997. Polyamine-bound trypsin inhibitors in sweet potato (Ipomoea batatas [L.] Lam cv. Tainong 57) storage roots, sprouted roots and sprouts. Plant Sci. 126: 11-19.
10. Hou, W.C., Y.C. Chen, H.J. Chen, Y.H. Lin, L.L. Yang, and M.H. Lee. 2001. Antioxidant activities of trypsin inhibitor, a 33 kDa root storage protein of sweet potato (Ipomoea batatas (L.) Lam cv. Tainong 57). J Agric. Food Chem. 49: 2978-2981.
11. Hou, W.C., D.J. Huang, and Y.H. Lin. 2002. An aspartic type protease degrades trypsin inhibitors, the major root storage proteins of sweet potato (Ipomoea batatas (L.) Lam cv. Tainong 57). Bot. Bull. Acad. Sin. 43: 271-276.
12. Hou, W.C., H.J. Chen, and Y.H. Lin. 2003. Antioxidant peptides with angiotensin converting enzyme inhibitory activities and applications for angiotensin converting enzyme purification. J. Agric. Food Chem. 51: 1706-1709.
13. Hsu, F.L., Y.H. Lin, M.H. Lee, C.L. Lin, and W.C. Hou. 2002. Both dioscorin, the tuber storage protein of yam (Dioscorea alata cv. Tainong No. 1), and its peptic hydrolysates exhibited angiotensin converting enzyme inhibitory activities. J. Agric. Food Chem. 50: 6109-6013.
14. Huang, D.J. C.D. Lin, H.J. Chen, and Y.H. Lin. 2004. Antioxidant and antiproliferative activities of sweet potato (Ipomoea batatas [L.] Lam 'Tainong 57') constituents. Bot. Bull. Acad. Sin. 45: 179-186.
15. Huang, D.J., H.J. Chen, W.C. Hou, T.E. Chen, and Y.H. Lin. 2004. In vitro reduction of trypsin inhibitor by purified NADPH/ Thioredoxin system from sprouts of sweet potato (Ipomoea batatas (L.) Lam) storage roots. Plant Sci. 166: 435-441.
16. Huang, D.J., H.J. Chen, W.C. Hou, T.E. Chen, and Y.H. Lin. 2005. Isolation and characterization of cysteine proteinase cDNA from sweet potato (Ipomoea batatas [L.] Lam 'Tainong 57') storage roots. Plant Sci. 169: 423-431.
17. Huang, D.J., W.C. Hou, H.J. Chen, and Y.H. Lin. 2006. Sweet potato (Ipomoea batatas [L.] Lam 'Tainong 57') storage roots mucilage exhibited angiotensin converting enzyme inhibitory activities in vitro. Bot. Stud. 45: 397-402.
18. Huang, G.J., H. J. Chen, Y-S Chang, M-J Sheu, and Y.H. Lin. 2007. Recombinant sporamin and its synthesized peptides with antioxidant activities in vitro. Bot. Stud. 48: 133-140.
19. Huang, G.J., M.J. Sheu, H.J. Chen, Y.S. Chang, and Y.H. Lin. 2007. Inhibition of reactive nitrogen species in vitro and ex vivo by trypsin inhibitor from sweet potato 'Tainong 57' storage roots. J. Agric. Food Chem. 55: 6000-6006.
20. Kohmura, M., N. Nio, K. Kubo, Y. Minoshima, E. Munekata, and Y. Ariyoshi. 1989. Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of human β-casein. Agric. Biol. Chem. 53: 2107-2114.
21. Kohmura, M., N. Nio, and Y. Ariyoshi. 1990. Inhibition of angiotensinconverting enzyme by synthetic peptide fragments of human β-casein. Agric. Biol. Chem. 54: 835-836.
22. Lin, Y.H. and H.L. Chen. 1980. Level and heat stability of trypsin inhibitor activity among sweet potato (Ipomoea batatas Lam.) varieties. Bot. Bull. Acad. Sin.21: 1-13.
23. Lin, Y.H. 1989. Relationship between trypsin-inhibitor activity and water-soluble protein and cumulative rainfall in sweet potato. J. Am. Soc. Hortic. Sci. 114: 814-818.
24. Lin, Y.H. 1993. Trypsin inhibitors of sweet potato: review and prospect. In Y. I. Hsing and C. H. Chou (eds.), Recent Advances in Botany, Academia Sinica Monograph series 13, Taipei, Taiwan, pp. 179-185.
25. Maruyama, S., H. Mitachi, J. Awaya, M. Kurono, N. Tomizuka, and H. Suzuki. 1987. Angiotensin I-converting enzyme inhibitory activity of the C-terminal hexapeptide of as1-casein. Agric. Biol. Chem. 51: 2557-2561.
26. Matsuoka, K., S. Matsumoto, T. Hattori, Y. Machida, K. Nakamura, and M. Maeshima. 1990. Vacuolar targeting and posttranslational processing of the precursor to the sweet potato tuberous root storage protein in heterologous plant cells. J. Biol. Chem. 265: 19750-19957.
27. Maubois, J.L. and J. Leonil. 1989. Peptides du lait a activite biologique. Lait. 69: 245-269.
28. Mullally, M.M., H. Meisel, and R.J. Fitzgerald. 1996. Synthetic peptides corresponding to α-lactalbumin and β-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. J. Biol. Chem. 377: 259-260.
29. Parker, F., O. Migliore-Samour, F. Floch, A. Zerial, G.H. Werner, J. Jolles, M. Casaretto, H. Zahn, and P. Jolles. 1984. Immunostimulating hexapeptide from human case in amino acid sequence, synthesis and biological properties. Eur. J. Biochem. 145: 677-682.
30. Pihlanto-Leppälä, A., T. Rokka, and H. Korhonen. 1998. Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy J. 8: 325-331.
31. Pihlanto-Leppälä A. P. Koskinen, K. Piilola, T. Tupasela, and H. Korhonen. 2000. Angiotensin I-converting enzyme inhibitory properties of whey protein digest: concentration and characterization of active peptides. J. Dairy Sci. 67: 53-64.
32. Ryan, C.A. 1973. Proteolytic enzymes and their inhibitors in plants. Annu. Rev. Plant Physiol. 24: 173-196.
33. Ryan, C.A. 1989. Protease inhibitor gene families: Strategies for transformation to improve plant defenses against herbivores. BioEssays 10: 20-24.
34. Scarborough, R.H., J.W. Rose, M.H. Hsu, D.R. Phillips, V.A. Fried, A.M. Campbell, L. Manniaai, and I. F.Charo. 1991. Barbourin A GpIIb-IIIa specific integrin antagonist from the venom of sistrurus M. Barbouri. J. Biol. Chem. 266: 9359-9360.
35. Shin, Z.I., R. Yu, S.A Park, D.K Chung, C.W. Ahn, H.S. Nam, K.S. Kim, and H.J. Lee. 2001. His-His-Leu, an angiotensin I converting enzyme inhibitory peptide derived from Korean soybean paste, exerts antihypertensive activity in vivo. J. Agric. Food Chem. 49: 3004-3009.
36. Sohonie, K. and A.P. Bhandarker. 1954. Trypsin inhibitors in Indian foodstuffs: I. Inhibitors in vegetables. J. Sci. Ind. Res. 13B: 500-503.
37. Yamamoto, N., M. Maeno, and T. Takano. 1999. Purification and characterization of an antihypertensive peptide from a yogurt-like product fermented by Lactobacillus helveticus CPN4. J. Dairy Sci. 82: 1388-1393.
38. Yano, S., K. Suzuki, and G. Funatsu. 1996. Isolation from azein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci. Biotechnol. Biochem. 60: 661-663.
39. Yeh, K.W., J.C. Chen, M.I. Lin, Y.M. Chen, and C.Y. Lin. 1997. Functional activity of sporamin from sweet potato (Ipomoea batatas Lam): a tuber storage protein with trypsin inhibitory activity. Plant Mol. Biol. 33: 565-570.
40. Yoshii, H., N. Tachi, R. Ohba, O. Sakamura, H. Takeyama, and T. Itani. 2001. Antihypertensive effect of ACE inhibitory oligopeptides from checken egg yolks. Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol. 128: 27-33.