Effect of the active site D25N mutation on the structure, stability, and ligand binding of the mature HIV-1 protease

Journal of Biological Chemistry

Volumn 283, Issue 19, 2008, Pages 13459-13470

  Sayer, Jane M ^a   Liu, Fengling ^b   Ishima, Rieko ^c   Weber, Irene T ^b   Louis, John M ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; BIOCHEMISTRY; CRYSTAL STRUCTURE; LIGANDS; MONOMERS; NUCLEAR MAGNETIC RESONANCE; OLIGOMERS;

ACTIVE SITES; ASPARTIC PROTEASES; CATALYTIC FUNCTIONS; DIFFERENTIAL SCANNING CALORIMETRIC; DIMER DISSOCIATIONS; DIMERIC STRUCTURES; HIGH RESOLUTION CRYSTAL STRUCTURES; LIGAND BINDINGS; LIGAND DISSOCIATIONS; NMR STUDIES; STRUCTURAL DIFFERENCES; SUBSTRATE ANALOGUES; TIGHT BINDINGS;

DISSOCIATION;

DARUNAVIR; DIMER; MONOMER; PROTEINASE; PROTEINASE INHIBITOR; VIRUS ENZYME; ASPARTIC ACID; LIGAND; P16 PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS 1;

ARTICLE; BINDING AFFINITY; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; ENZYME ACTIVE SITE; ENZYME INHIBITOR COMPLEX; ENZYME STRUCTURE; GEOMETRY; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; PRIORITY JOURNAL; PROTEINASE INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; THERMOSTABILITY; X RAY DIFFRACTION; BINDING SITE; CALORIMETRY; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; ENZYME STABILITY; GENETICS; METABOLISM; MUTATION; NUCLEAR MAGNETIC RESONANCE; PROTEIN TERTIARY STRUCTURE; STRUCTURAL HOMOLOGY; TEMPERATURE; X RAY CRYSTALLOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ASPARTIC ACID; BINDING SITES; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENZYME STABILITY; HIV PROTEASE; HIV PROTEASE INHIBITORS; LIGANDS; MODELS, MOLECULAR; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, TERTIARY; STRUCTURAL HOMOLOGY, PROTEIN; TEMPERATURE;

EID: 45149083375     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708506200     Document Type: Article

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