Glucocorticoid suppression of CX3CL1 (fractalkine) by reduced gene promoter recruitment of NF-κB

FASEB Journal

Volumn 22, Issue 6, 2008, Pages 1807-1816

  Bhavsar, Pankaj K ^a   Sukkar, Maria B ^a   Khorasani, Nadia ^a   Lee, Kang Yun ^a   Chung, Kian Fan ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Chromatin; Displacement; Epithelial cells; Transcription factor

Indexed keywords

1 [5 HYDROXY 2 (2 THIENYL) 4 QUINAZOLINYLAMINO] 3 METHYL 2,5 PYRROLEDIONE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; DEXAMETHASONE; FRACTALKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MIFEPRISTONE; SYNAPTOTAGMIN I; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DNA BINDING; DNA SEQUENCE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; CELL LINE; CYTOLOGY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROMOTER REGION; RESPIRATORY TRACT MUCOSA;

CELL LINE; CHEMOKINE CX3CL1; DEXAMETHASONE; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; NF-KAPPA B; PROMOTER REGIONS (GENETICS); RECEPTORS, GLUCOCORTICOID; RESPIRATORY MUCOSA;

EID: 44949262975     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.07-094235     Document Type: Article

References (39)

1. Rhen, T., and Cidlowski, J. A. (2005) Antiinflammatory action of glucocorticoids - new mechanisms for old drugs. N. Engl. J. Med. 353, 1711-1723
2. Nissen, R. M., and Yamamoto, K. R. (2000) The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev. 14, 2314-2329
3. De Bosscher, K., Vanden Berghe, W., Vermeulen, L., Plaisance, S., Boone, E., and Haegeman, G. (2000) Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell. Proc. Natl. Acad. Sci. U. S. A. 97, 3919-3924
4. Abbinante-Nissen, J. M., Simpson, L. G., and Leikauf, G. D. (1995) Corticosteroids increase secretory leukocyte protease inhibitor transcript levels in airway epithelial cells. Am. J. Physiol. 268, L601-L606
5. Lasa, M., Abraham, S. M., Boucheron, C., Saklatvala, J., and Clark, A. R. (2002) Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. Mol. Cell. Biol. 22, 7802-7811
6. Polito, A. J., and Proud, D. (1998) Epithelia cells as regulators of airway inflammation. J. Allergy Clin. Immunol. 102, 714-718
7. El Shazly, A., Berger, P., Girodet, P. O., Ousova, O., Fayon, M., Vernejoux, J. M., Marthan, R., and Tunon-de-Lara, J. M. (2006) Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma. J. Immunol. 176, 1860-1868
8. Rimaniol, A. C., Till, S. J., Garcia, G., Capel, F., Godot, V., Balabanian, K., Durand-Gasselin, I., Varga, E. M., Simonneau, G., Emilie, D., Durham, S. R., and Humbert, M. (2003) The CX3C chemokine fractalkine in allergic asthma and rhinitis. J. Allergy Clin. Immunol. 112, 1139-1146
9. Ning, W., Li, C. J., Kaminski, N., Feghali-Bostwick, C. A., Alber, S. M., Di, Y. P., Otterbein, S. L., Song, R., Hayashi, S., Zhou, Z., Pinsky, D. J., Watkins, S. C., Pilewski, J. M., Sciurba, F. C., Peters, D. G., Hogg, J. C., and Choi, A. M. (2004) Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc. Natl. Acad. Sci. U. S. A. 101, 14895-14900
10. Murphy, P. M., Baggiolini, M., Charo, I. F., Hebert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., and Power, C. A. (2000) International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol. Rev. 52, 145-176
11. Garton, K. J., Gough, P. J., Blobel, C. P., Murphy, G., Greaves, D. R., Dempsey, P. J., and Raines, E. W. (2001) Tumor necrosis factor-α- converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J. Biol. Chem. 276, 37993-38001
12. Imaizumi, T., Matsumiya, T., Fujimoto, K., Okamoto, K., Cui, X., Ohtaki, U., Hidemi, Y., and Satoh, K. (2000) Interferon-γ stimulates the expression of CX3CL1/fractalkine in cultured human endothelial cells. Tohoku J. Exp. Med. 192, 127-139
13. Chen, Y. M., Tu, C. J., Hung, K. Y., Wu, K. D., Tsai, T. J., and Hsieh, B. S. (2003) Inhibition by pentoxifylline of TNF-α-stimulated fractalkine production in vascular smooth muscle cells: evidence for mediation by NF-κB down-regulation. Br. J. Pharmacol. 138, 950-958
14. Fahy, O. L., Coates, N. J., and McColl, S. R. (2003) Inhibition of cytokine-induced fractalkine production by bacterial invasion of human-dermal fibroblasts. Lab. Invest. 83, 721-730
15. Yoshida, H., Imaizumi, T., Fujimoto, K., Matsuo, N., Kimura, K., Cui, X., Matsumiya, T., Tanji, K., Shibata, T., Tamo, W., Kumagai, M., and Satoh, K. (2001) Synergistic stimulation, by tumor necrosis factor-α and interferon-γ, of fractalkine expression in human astrocytes. Neurosci. Lett. 303, 132-136
16. Sukkar, M. B., Issa, R., Xie, S., Oltmanns, U., Newton, R., and Chung, K. F. (2004) Fractalkine/CX3CL1 production by human airway smooth muscle cells: induction by IFN-γ and TNF-α and regulation by TGF-β and corticosteroids. Am. J. Physiol. 287, L1230-L1240
17. Adcock, I. M. (2001) Glucocorticoid-regulated transcription factors. Pulm. Pharmacol. Ther. 14, 211-219
18. Li, Q., and Verma, I. M. (2002) NF-κB regulation in the immune system. Nat. Rev. Immunol. 2, 725-734
19. Barker, J. N., Sarma, V., Mitra, R. S., Dixit, V. M., and Nickoloff, B. J. (1990) Marked synergism between tumor necrosis factor-α and interferon-γ in regulation of keratinocyte-derived adhesion molecules and chemotactic factors. J. Clin. Invest. 85, 605-608
20. Johnson, D. R., and Pober, J. S. (1994) HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons. Mol. Cell. Biol. 14, 1322-1332
21. Levy, D. E., Lew, D. J., Decker, T., Kessler, D. S., and Darnell, J. E., Jr. (1990) Synergistic interaction between interferon-α and interferon-γ through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J. 9, 1105-1111
22. Baeuerle, P. A., and Henkel, T. (1994) Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12, 141-179
23. Ohmori, Y., and Hamilton, T. A. (1995) The interferon-stimulated response element and a κB site mediate synergistic induction of murine IP-10 gene transcription by IFN-γ and TNF-α. J. Immunol. 154, 5235-5244
24. Jahnke, A., and Johnson, J. P. (1994) Synergistic activation of intercellular adhesion molecule 1 (ICAM-1) by TNF-α and IFN-γ is mediated by p65/p50 and p65/c-Rel and interferon-responsive factor Stat1α (p91) that can be activated by both IFN-γ and IFN-α. FEBS Lett. 354, 220-226
25. Lee, A. H., Hong, J. H., and Seo, Y. S. (2000) Tumour necrosis factor-α and interferon-γ synergistically activate the RANTES promoter through nuclear factor κB and interferon regulatory factor 1 (IRF-1) transcription factors. Biochem. J. 350 (Pt 1), 131-138
26. Imanishi, D., Yamamoto, K., Tsushima, H., Miyazaki, Y., Kuriyama, K., Tomonaga, M., and Matsuyama, T. (2000) Identification of a novel cytokine response element in the human IFN regulatory factor-1 gene promoter. J. Immunol. 165, 3907-3916
27. Ray, A., and Prefontaine, K. E. (1994) Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc. Natl. Acad. Sci. U. S. A. 91, 752-756
28. Frelin, C., Imbert, V., Griessinger, E., Loubat, A., Dreano, M., and Peyron, J. F. (2003) AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-α in Jurkat leukemic cells. Oncogene 22, 8187-8194
29. Kochetkova, M., and Shannon, M. F. (1996) DNA triplex formation selectively inhibits granulocyte-macrophage colony-stimulating factor gene expression in human T cells. J. Biol. Chem. 271, 14438-14444
30. Catley, M. C., Chivers, J. E., Holden, N. S., Barnes, P. J., and Newton, R. (2005) Validation of IKKβ as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKKβ to pulmonary epithelial cells. Br. J. Pharmacol. 145, 114-122
31. Ito, K., Barnes, P. J., and Adcock, I. M. (2000) Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1β-induced histone H4 acetylation on lysines 8 and 12. Mol. Cell. Biol. 20, 6891-6903
32. Novac, N., Baus, D., Dostert, A., and Heinzel, T. (2006) Competition between glucocorticoid receptor and NFκB for control of the human FasL promoter. FASEB J. 20, 1074-1081
33. Scheinman, R. I., Cogswell, P. C., Lofquist, A. K., and Baldwin, A. S., Jr. (1995) Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270, 283-286
34. Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., and Karin, M. (1995) Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 270, 286-290
35. Brostjan, C., Anrather, J., Csizmadia, V., Stroka, D., Soares, M., Bach, F. H., and Winkler, H. (1996) Glucocorticoid-mediated repression of NFκB activity in endothelial cells does not involve induction of IκBα synthesis. J. Biol. Chem. 271, 19612-19616
36. Newton, R., Hart, L. A., Stevens, D. A., Bergmann, M., Donnelly, L. E., Adcock, I. M., and Barnes, P. J. (1998) Effect of dexamethasone on interleukin-1β-(IL-1β)-induced nuclear factor-κB (NF-κB) and κB-dependent transcription in epithelial cells. Eur. J. Biochem. 254, 81-89
37. Ito, K., Yamamura, S., Essilfie-Quaye, S., Cosio, B., Ito, M., Barnes, P. J., and Adcock, I. M. (2006) Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression. J. Exp. Med. 203, 7-13
38. Garside, H., Stevens, A., Farrow, S., Normand, C., Houle, B., Berry, A., Maschera, B., and Ray, D. (2004) Glucocorticoid ligands specify different interactions with NF-κB by allosteric effects on the glucocorticoid receptor DNA binding domain. J. Biol. Chem. 279, 50050-50059
39. Menetski, J. P. (2000) The structure of the nuclear factor-κB protein-DNA complex varies with DNA-binding site sequence. J. Biol. Chem. 275, 7619-7625