Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells by disrupting the myosin II-actin interaction

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 5, 2008, Pages

  Hong, Hui Wang ^a   Tanaka, Hideyuki ^b   Qin, Xiaoran ^a,c   Zhao, Tiejun ^a,c   Ye, Li Hong ^a,c   Okagaki, Tuyoshi ^d   Katayama, Takeshi ^a   Nakamura, Akio ^a   Ishikawa, Ryoki ^a   Thatcher, Sean E ^e   Wright, Gary L ^e   Kohama, Kazuhiro ^a,f,g  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b GUNMA UNIVERSITY   (Japan)

^c NANKAI UNIVERSITY   (China)

^d MIE UNIVERSITY   (Japan)

^e MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f MARSHALL UNIVERSITY   (United States)

^g GUNMA UNIVERSITY   (Japan)

Author keywords

ATPase; Boyden chamber; Electron microscopy; Fluorescence resonance energy transfer; In vitro motility assay

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATASE (MAGNESIUM); BLEBBISTATIN; MEROMYOSIN; MYOSIN II; SPHINGOSYLPHOSPHORYLCHOLINE; DRUG DERIVATIVE; ENZYME INHIBITOR; FUSED HETEROCYCLIC RINGS; MYOSIN SUBFRAGMENT; PHOSPHORYLCHOLINE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BB; PLATELET-DERIVED GROWTH FACTOR BB; SPHINGOSINE; SPHINGOSINE PHOSPHORYLCHOLINE;

ANIMAL CELL; ARTICLE; CHEMOTAXIS; CONFORMATIONAL TRANSITION; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; ANIMAL; CATTLE; CELL LINE; CHICKEN; CONFOCAL MICROSCOPY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ELECTRON MICROSCOPY; ENZYMOLOGY; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT ANTIBODY TECHNIQUE; GUINEA PIG; METABOLISM; PHOSPHORYLATION; PROTEIN CONFORMATION; RAT; ULTRASTRUCTURE;

ACTINS; ANIMALS; CATTLE; CELL LINE; CHEMOTAXIS; CHICKENS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT ANTIBODY TECHNIQUE; GUINEA PIGS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; MYOSIN SUBFRAGMENTS; MYOSIN TYPE II; PHOSPHORYLATION; PHOSPHORYLCHOLINE; PLATELET-DERIVED GROWTH FACTOR; PROTEIN CONFORMATION; RATS; SPHINGOSINE;

EID: 44949206620     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00970.2007     Document Type: Article

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