Hibiscus sabdariffa L. extracts inhibit the mutagenicity in microsuspension assay and the proliferation of HeLa cells

Journal of Food Science

Volumn 73, Issue 5, 2008, Pages

  Olvera Garcia V ^a   Castano Tostado E ^a   Rezendiz Lopez, R I ^a   Reynoso Camacho, R ^a   Gonzalez De Mejia E ^b   Elizondo, G ^c   Loarca Pina G ^a  

^a UNIVERSIDAD AUTÓNOMA DE QUERÉTARO   (Mexico)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

1 NP; HeLa cells; Hibiscus sabdariffa L.; Microsuspension assay; Protocatechuic acid

Indexed keywords

1 NITROPYRENE; 1-NITROPYRENE; ANTIMUTAGENIC AGENT; PHENOL DERIVATIVE; PLANT EXTRACT; PYRENE DERIVATIVE;

ARTICLE; CELL DIVISION; CHEMISTRY; DNA FRAGMENTATION; DOSE RESPONSE; DRUG EFFECT; HELA CELL; HIBISCUS; HUMAN; MUTAGEN TESTING; SAFETY;

ANTIMUTAGENIC AGENTS; CELL DIVISION; CONSUMER PRODUCT SAFETY; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HIBISCUS; HUMANS; MUTAGENICITY TESTS; PHENOLS; PLANT EXTRACTS; PYRENES;

HIBISCUS; HIBISCUS SABDARIFFA;

EID: 44949177509     PISSN: 00221147     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2008.00781.x     Document Type: Article

References (45)

1. Afaq F, Saleem M, Krueger CG, Reed JD, Mukhtar H. 2005. Anthocyanin and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-κb pathways and inhibits skin tumorigenesis in CD-1 mice. Int J Cancer 13 : 423 33.
2. Akindahunsi AA, Olaleye MT. 2003. Toxicological investigation of aqueous-methanolic extract of the calyces of Hibiscus sabdariffa L. J Ethnopharmacol 89 : 161 4.
3. Ali BH, Wabel NA, Blunden G. 2005. Phytochemical and toxicological aspects of Hibiscus sabdariffa L. A review. Phytother Res 19 : 369 75.
4. Ames BN, McCann J, Yamasaki E. 1975. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test. Mutat Res 31 : 347 64.
5. Babich H, Sedletcaia A, Kenigsberg B. 2002. In vitro cytotoxicity of protocatechuic acid to cultured human cells from oral tissue: involvement in oxidative stress. Pharmacol Toxicol 91 : 245 53.
6. Barnard RJ. 2004. Prevention of cancer through lifestyle changes. Evidence-based complement. Alternat Med 1 : 233 9.
7. Chen C, Kong AT. 2005. Dietary cancer-chemopreventive compounds: from signalling and gene expression to pharmacological effects. Trends Pharmacol Sci 26 : 318 26.
8. Chen CC, Hsu JD, Wang SF, Chiang HC, Yang MY, Kao ES, Ho Wang CJ. 2003. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J Agric Food Chem 51 : 5472 7.
9. Chewonarin T, Kinouchi T, Kataoka K, Arimochi H, Kuwahara T, Vinitketkumnuen U, Ohnishi Y. 1999. Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2 amino-1-methyl-6-phenylimidazo[4,5-b] pyridine in F344 rats. Food Chem Toxicol 37 : 591 601.
10. El-Bayoumy K, Upadhyaya CP, Rivenson A, Kurtzke C, Reddy B, Hecht SS. 1995. Comparative tumorigenicity of benzo(a)pyrene, 1-nitropyrene and 2-amino-1 methyl-6-phenylimidazo(4,5-b)pyridine administered by gavage to female CD rats. Carcinogenesis 16 : 431 4.
11. Ember I, Pusztai Z, Gyöngyi Z, Kiss I. 2000. 1-Nitropyrene induces elevated expression of oncogenes and tumor suppressor genes 24 hours after treatment in CBA/Ca mice. Anticancer Res 20 : 1563 6.
12. Falade OS, Otemuyiwa IO, Oladipo A, Oyedapo OO, Akinpelu BA, Adewusi SR. 2005. The chemical composition and membrane stability activity of some herbs used in local therapy for anemia. J Ethnopharmacol 102 (1 15 22.
13. Furlong IJ, Ascaso R, Lopez Rivas A, Collins MK. 1997. Intracellular acidification induces apoptosis by stimulating ICE-like protease activity. J Cell Sci 110 : 653 61.
14. González de Mejía E, Ramos-Gómez M, Loarca-Piña G. 1997. Antimutagenicity of xanthophylls present in Aztec marigold (Tagetes erecta) against 1-nitropyrene. Mutat Res 389 : 219 26.
15. Hirunpanich V, Utaipat A, Morales NP, Bunyapraphatsara N, Sato H, Herunsale A, Suthisisang A. 2006. Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats. J Etnophamacol 103 : 252 60.
16. Hsieh YJ, Lin WL, Chou FP, Wang CJ, Cheng MT, Tseng TH. 2003. Hibiscus protocatechuic acid inhibits lipopolysaccharide-induced rat hepatic damage. Arch Toxicol 77 : 42 7.
17. Huang Y, Cao S, Nagamani M, Anderson KE, Grady JJ, Lu LW. 2005. Decreased circulating levels of tumor necrosis factor-alpha (TNF-α) in postmenopausal 1 women during consumption of soy containing isoflavones. J Clin Endocrinol Metab 90 (7 3952 62.
18. Johnson IT. 2005. Cancers of the gut and western ills. Science 307 : 1839.
19. Kado NY, Langley D, Eisenstad E. 1983. A simple modification of the Salmonella liquid incubation assay increased sensitivity for detecting mutagens in human urine. Mutat Res 121 : 25 32.
20. Kado NY, Guirguis GN, Flessel CP, Chan RC, Chang K-I, Wesolowski JJ. 1986. Mutagenicity of fine (<2.5 μm) airborne particles: diurnal variation in community air determined by a Salmonella micro preincubation (microsuspension) procedure. Environ Mutagen 8 : 56 99.
21. Lin WL, Hsieh YJ, Chou FP, Wang CJ, Cheng MT, Tseng TH 2003. Hibiscus protocatechuic acid inhibits lipopolysaccharide-induced rat hepatic damage. Arch Toxicol 77 : 42 7.
22. Liu Y, Chen C, Wang W, Hsu J, Yang M, Wang C. 2006. The protective effects of Hibiscus sabdariffa extract on CCl4-induced liver fibrosis in rats. Food Chem Toxicol 44 : 336 43.
23. 1 in the Salmonella microsusupension assay. Mutat Res 360 : 15 21.
24. Milner JA. 2003. Incorporating basic nutrition science into health interventions for cancerprevention. J Nutr 133 (11, Suppl 1 3820S 6S.
25. Mottier P, Parisod V, Turesky JR. 2002. Quantitative determination of polycyclic aromatic hydrocarbon in barbecued meat sausages by gas chromatography coupled to mass spectrometry. J Agric Food Chem 48 : 1160 6.
26. Nakamura Y, Torikai K, Ohto Y, Murakami AT, Tanaka T, Ohigashi H. 2000. A simple phenolic antioxidant protocatechuic acid enhances tumor promotion and oxidative stress in female ICR mouse skin: dose-and timing-dependent enhancement and involvement of bioactivation by tyrosinase. Carcinogenesis 21 : 1899 907.
27. Nakamura Y, Torikai K, Ohigashi H. 2001a. A catechol antioxidant protocatechuic acid potentiates inflammatory leukocyte-derived oxidative stress in mouse skin via a tyrosinase biactivation pathway. Free Radic Biol Med 30 : 967 78.
28. Nakamura Y, Torikai K, Ohigashi H. 2001b. Toxic dose of a simple phenolic antioxidant, protocatechuic acid, attenuates the glutathione level in ICR mouse liver and kidney. J Agric Food Chem 49 : 5674 8.
29. Odigie IP, Ettarh RR, Adigun SA. 2003. Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K 1C hypertensive rats. J Ethnopharmacol 86 : 181 5.
30. Park HJ, Lyons JC, Ohtsubo T, Song CW. 1999. Acidic environment causes apoptosis by increasing caspase activity. Br J Cancer 80 : 1892 7.
31. Pouget MP, Lejeune B, Vennat B, Pourrat A. 1990. Identification of anthocyanins of Hibiscus sabdariffa L. Lebensm Wiss Technol 23 : 101 2.
32. Pusztai Z, Ember I, Selypes A. 1998. Short-term effects of 1-nitropyrene on chromosomes and on oncogene/tumor suppressor gene expression in vivo. Anticancer Res 18 : 4489 92.
33. Rosenkranz HS, Mermelstein R. 1983. Mutagenecity and genotoxicity of nitroarenes. All nitro-containing chemicals were not created equal. Mutat Res 114 : 217 67.
34. Schmidt BM, Howell AB, Mceniry B, Knight CT, Seigler D, Erdman JW Jr., D Lila MA. 2004. Effective separation of potent antiproliferation and antiadhesion components from wild blueberry (Vaccinium angustifolium Ait.) fruits. J Agric Food Chem 52 : 6433 42.
35. Sera N, Morita K, Nagasoe M, Tokieda H, Kitaura T, Tokiwa H. 2005. Binding effect of polychlorinated compounds and environmental carcinogens on rice bran fiber. J Nutr Biochem 16 : 50 8.
36. Shahidi F, Naczk M. 2004. Biosynthesis, classification and nomenclature of phenolics in food and nutraceuticals. Boca Raton, Fla. : CRC Press. p 2 13.
37. Strohle A, Wolters M, Hahn A. 2005. Folic acid and colorectal cancer prevention: molecular mechanisms and epidemiological evidence (review). Int J Oncol 26 (6 1449 64.
38. Suboh SM, Bilto YY, Aburjai TA. 2004. Protective effects of selected medicinal plants against protein degradation, lipid peroxidation and deformability loss of oxidatively stressed human erythrocytes. Phytother Res 18 : 280 4.
39. Takasu T, Lyons JC, Park HJ, Song CW. 1998. Apoptosis and perturbation of cell cycle progression in an acidic environment after hyperthermia. Cancer Res 58 : 2504 8.
40. Tseng TH, Wang CJ, Kao ES, Chu HY. 1996. Hibiscus protocatechuic acid protects against oxidative damage induced by tert-butylhydroperoxide in rat primary hepatocytes. Chem Biol Interact 101 : 137 48.
41. Tseng TH, Kao ES, Chu CY, Chou FP, Lin Wo HW, Wang CJ. 1997. Protective effects of dried flower extracts of Hibiscus sabdariffa L. against oxidative stress in rat primary hepatocytes. Food Chem Toxicol 35 : 1159 64.
42. Tseng TH, Hsu JD, Lo MH, Chu CY, Chou FP, Huang CL, Wang CJ. 1998. Inhibitory effect of hibiscus protocatechuic acid on tumor promotion in mouse skin. Cancer Lett 126 : 199 207.
43. Tseng TH, Kao TW, Chu CY, Chou FP, Lin WL, Wang CJ. 2000. Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression. Biochem Pharmacol 60 : 307 15.
44. von Euler H, Soderstedt A, Thorne A, Olsson JM, Yongqing G. 2002. Cellular toxicity induced by different pH levels on the R3230AC rat mammary tumour cell line. An in vitro model for investigation of the tumour destructive properties of electrochemical treatment of tumours. Bioelectrochemistry 58 : 163 70
45. Zheng Q, Hirose Y, Yoshimi N, Murakami A, Koshimizu K, Ohigasi H, Sakata K, Matsumoto Y, Sayama Y, Mori H. 2002. Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells. J Cancer Res Clin Oncol 128 : 539 46.