Plasmodium falciparum: Detection of the deoxyxylulose 5-phosphate reductoisomerase activity

Experimental Parasitology

Volumn 96, Issue 3, 2000, Pages 182-186

  Wiesner, J ^a   Hintz, M ^a   Altincicek, B ^a   Sanderbrand, S ^a   Weidemeyer, C ^a   Beck, E ^a   Jomaa, H ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 (N ACETYL N HYDROXYAMINO)PROPYLPHOSPHONIC ACID; ANTIMALARIAL AGENT; CYTIDINE DIPHOSPHATE; CYTIDINE TRIPHOSPHATE; FOSMIDOMYCIN; ISOMERASE;

ANTIMALARIAL ACTIVITY; ARTICLE; ENZYME ACTIVITY; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERIZATION; PRIORITY JOURNAL;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0034522796     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.2000.4566     Document Type: Article

References (8)

1. Biochemistry of polyisoprenoid biosynthesis
2. Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate
3. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
4. Fosmidomycin, a specific inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway of isoprenoid biosynthesis
5. Cytidine 5′-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol
6. The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants
7. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol
8. Inhibition of the non-mevalonate 1-deoxy-D-xylulose-5-phosphate pathway of plant isoprenoid biosynthesis by fosmidomycin