Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 13, 2008, Pages 3706-3710

  Liang, Gui Bai ^a   Qian, Xiaoxia ^a   Biftu, Tesfaye ^a   Singh, Suresh ^a   Gao, Ying Duo ^a   Scapin, Giovanna ^a   Patel, Sangita ^a   Leiting, Barbara ^a   Patel, Reshma ^a   Wu, Joseph ^a   Zhang, Xiaoping ^a   Thornberry, Nancy A ^a   Weber, Ann E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Diabetes; DPP 4 inhibitors; Fluorine H bond

Indexed keywords

AMIDE; ASPARTIC ACID; BETA ALANINE; CARBONIC ACID; CARBONYL DERIVATIVE; CESIUM; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DIPYRONE; FLUORINE; FLUOROPYRROLIDINE AMIDE; GLYCINE; METHYL GROUP; NITRILE; NITROGEN; OXADIAZOLE DERIVATIVE; OXYGEN; PHENYLACETIC ACID; SITAGLIPTIN; VALEROLACTAM;

ALKYLATION; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; HYDROGEN BOND; HYDROPHOBICITY; METHYLATION; MICHAEL ADDITION; NONHUMAN; SUZUKI REACTION; X RAY CRYSTALLOGRAPHY;

ANTIGENS, CD26; BETA-ALANINE; BINDING SITES; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FLUORINE; GLYCINE; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MODELS, THEORETICAL; MOLECULAR CONFORMATION; SOFTWARE;

EID: 44849112519     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.061     Document Type: Article

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