Potent and selective proline derived dipeptidyl peptidase IV inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 20, 2004, Pages 5151-5155

  Edmondson, Scott D ^a   Mastracchio, Anthony ^a   Beconi, Maria ^a   Colwell Jr , Lawrence F ^a   Habulihaz, Bahanu ^a   He, Huaibing ^a   Kumar, Sanjeev ^a   Leiting, Barbara ^a   Lyons, Kathryn A ^a   Mao, Ann ^a   Marsilio, Frank ^a   Patel, Reshma A ^a   Wu, Joseph K ^a   Zhu, Lan ^a   Thornberry, Nancy A ^a   Weber, Ann E ^a   Parmee, Emma R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Dipeptidyl peptidase IV; Proline amide; Selective; Thiazolidine; Type 2 diabetes

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; PEPTIDE HYDROLASE INHIBITOR; PHENYLALANINE; PROLINE DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, CD26; BIOLOGICAL AVAILABILITY; HUMANS; PROLINE; PROTEASE INHIBITORS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4544376832     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.07.056     Document Type: Article

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