Small heat-shock protein structures reveal a continuum from symmetric to variable assemblies

Journal of Molecular Biology

Volumn 298, Issue 2, 2000, Pages 261-272

  Haley, Dana A ^a,b   Bova, Michael P ^b   Huang, Qing Ling ^b   Mchaourab, Hassane S ^c   Stewart, Phoebe L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JULES STEIN EYE INSTITUTE   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Alpha crystallin; Cryo electron microscopy; Small heat shock protein; Three dimensional reconstruction; Variable structure

Indexed keywords

ALPHA LACTALBUMIN; CRYSTALLIN; HEAT SHOCK PROTEIN; POLYPEPTIDE;

ARTICLE; CRYOELECTRON MICROSCOPY; CRYSTAL STRUCTURE; GEL FILTRATION CHROMATOGRAPHY; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN STRUCTURE;

EID: 0034724559     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3657     Document Type: Article

References (47)

1. Cryo-electron microscopy of viruses
2. A 9 Å-resolution X-ray crystallographic map of the large ribosomal subunit
3. Supramolecular structure of the recombinant murine small heat-shock protein HSP25
4. αB Subunit of lens-specific protein α-crystallin is present in other ocular and non-ocular tissues
5. Determination of the fold of the core protein of hepatitis B virus by electron cryo-microscopy
6. Subunit exchange of αA-crystallin
7. Probing the structure and interactions of crystallin proteins by NMR spectroscopy
8. NMR spectroscopy of α-crystallin. Insights into the structure, interactions and chaperone action of small heat-shock proteins
9. Mycobacterium tuberculosis 16-kDa antigen (HSP16.3) functions as an oligomeric structure in vitro to suppress thermal aggregation
10. Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase
11. Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy
12. Conformational properties of substrate proteins bound to a molecular chaperone α-crystallin
13. Genealogy of the α-crystallin: Small heat-shock protein superfamily
14. α-Crystallin as a molecular chaperone
15. The dynamics of HSP25 quaternary structure. Structure and function of different oligomeric species
16. Structure and modifications of the junior chaperone α-crystallin. From lens transparency to molecular pathology
17. The small heat-shock protein, αB-crystallin, has a variable quaternary structure
18. Overexpression and abnormal modification of the stress proteins αB-crystallin and HSP27 in Alexander disease
19. Coordinate and independent regulation of αB-crystallin and HSP27 expression in response to physiological stress
20. α-Crystallin can function as a molecular chaperone
21. Lens α-crystallin: Chaperone-like properties
22. Lens α-crystallin: Function and structure
23. Four small Drosophila heat-shock proteins are related to each other and to mammalian α-crystallin
24. Immunoreactive αA-crystallin in rat non-lenticular tissues detected with a sensitive immunoassay method
25. Crystal structure of a small heat-shock protein
26. Small heat-shock protein of Methanococcus jannaschii, a hyperthermophile
27. αB-Crystallin is a small heat-shock protein
28. Folding pattern of the α-crystallin domain in αA-crystallin determined by site-directed spin labeling
29. HSP27 multimerization mediated by phosphorylation-sensitive intermolecular interactions at the amino terminus
30. A small heat-shock protein stably binds heat-denatured model substrates and can maintain a substrate in a folding-competent state
31. Site-directed spin-labeling study of the structure and subunit interactions along a conserved sequence in the α-crystallin domain of heat-shock protein 27. Evidence of a conserved subunit interface
32. Structural perturbation of α-crystallin and its chaperone-like activity
33. αB-Crystallin is present in reactive glia in Creutzfeldt-Jakob disease
34. Expression of αB-crystallin in Alzheimer's disease
35. GroEL-GroES cycling: ATP and nonnative polypeptide direct alternation of folding-active rings
36. QVIEW: Software for rapid selection of particles from digital electron micrographs
37. αA-Crystallin is expressed in non-ocular tissues
38. Difference imaging of adenovirus: Bridging the resolution gap between X-ray crystallography and electron microscopy
39. Resolution issues in single particle reconstruction
40. A dynamic quaternary structure of bovine α-crystallin as indicated from intermolecular exchange of subunits
41. Angular reconstitution: A posteriori assignment of projection directions for 3D reconstruction
42. Similarity measures between images
43. A new generation of the IMAGIC image processing system
44. Multiple sclerosis: An altered immune response or an altered stress response?
45. Quaternary structure of bovine alpha-crystallin: Influence of temperature
46. The crystal structure of the human hepatitis B virus capsid
47. 7 chaperonin complex