Monoglycerides from the brown alga Sargassum sagamianum: Isolation, synthesis, and biological activity

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 12, 2008, Pages 3589-3592

  Chang, Hyeun Wook ^a   Jang, Kyoung Hwa ^b   Lee, Doohyun ^b   Kang, Hee Ryong ^b   Kim, Tae Yoon ^c   Lee, Bong Ho ^d   Choi, Byoung Wook ^d   Kim, Sanghee ^b   Shin, Jongheon ^b  

^a Yeungnam University   (South Korea)

^b Seoul National University   (South Korea)

^c The Catholic University of Korea   (South Korea)

^d Hanbat National University   (South Korea)

Author keywords

1 Octadecatetraenoyl glycerol; Bioactivity; Brown alga; Inhibition of cyclooxygenase 2; Inhibition of phospholipase A2; Polyunsaturated fatt acid derived monoglycerides; Synthesis

Indexed keywords

1 OCTADECATETRAENOYLGLYCEROL; CYCLOOXYGENASE 2; MONOACYLGLYCEROL; PHOSPHOLIPASE A2;

ARTICLE; BIOLOGICAL ACTIVITY; BROWN ALGA; CARBON NUCLEAR MAGNETIC RESONANCE; CHROMATOGRAPHY; DRUG INHIBITION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; SARGASSUM; SARGASSUM SAGAMIANUM; STRUCTURE ANALYSIS;

CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FATTY ACIDS, UNSATURATED; KOREA; MOLECULAR STRUCTURE; MONOGLYCERIDES; PHOSPHOLIPASES A2; SARGASSUM; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

PHAEOPHYCEAE; SARGASSUM SAGAMIANUM;

EID: 44849098626     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.008     Document Type: Article

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20. 2 concentrations in the medium were determined in triplicate using a commercially available enzyme immunoabsorbent assay (EIA) kit (Cayman Chemical Company, Ann Arbor, MI), following the manufacturer's protocol. The assay was performed in a total volume of 150 μL, with the following components added in 50 μL volumes: standards or biological samples, enzymatic tracer, and specific antiserum. After overnight incubation at 4 °C, the plates were washed, and 200 μL of Ellman's reagent was added to each well. After 1-3 h, the absorbance of each well was measured at 414 nm. A standard curve with values of 50-0.39 pg/mL was used to evaluate the concentrations
21. 2 activity was determined by means of a coupled enzyme assay using DL-PC as a substrate and lipoxygenase as a coupling enzyme. The linoleic acid released by phospholipase activity was oxidized by lipoxygenase, giving rise to the corresponding hydroperoxide derivative. The phospholipase activity was followed by measuring the absorbance at 234 nm