A novel mechanism of complement inhibition unmasked by a tick salivary protein that binds to properdin

Journal of Immunology

Volumn 180, Issue 6, 2008, Pages 3964-3968

  Tyson, Katharine R ^a   Elkins, Christopher ^a   De Silva, Aravinda M ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT FACTOR H; DECAY ACCELERATING FACTOR; INSECT PROTEIN; PROPERDIN; SALIVA PROTEIN; SALIVA PROTEIN 20; UNCLASSIFIED DRUG; COMPLEMENT INHIBITOR; ISAC PROTEIN, IXODES SCAPULARIS; IXOLARIS PROTEIN, IXODES SCAPULARIS;

ARTICLE; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT INHIBITION; CONTROLLED STUDY; ENZYME STABILITY; IXODES SCAPULARIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; HUMAN; IMMUNOLOGY; IXODES; METABOLISM; PHYSIOLOGY;

ANIMALS; COMPLEMENT C3-C5 CONVERTASES; COMPLEMENT INACTIVATOR PROTEINS; COMPLEMENT PATHWAY, ALTERNATIVE; HUMANS; IXODES; PROPERDIN; PROTEIN BINDING; SALIVARY PROTEINS;

EID: 44849083626     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.6.3964     Document Type: Article

References (34)

1. Burgdorfer, W., A. G. Barbour, S. F. Hayes, J. L. Benach, E. Grunwaldt, and J. P. Davis. 1982. Lyme disease - a tick-borne spirochetosis? Science 216: 1317-1319.
2. Sonenshine, D. E. 1993. Biology of Ticks. Oxford University Press, New York.
3. Wikel, S. K. 1999. Tick modulation of host immunity: an important factor in pathogen transmission. Int. J. Parasitol. 29: 851-859.
4. Lawrie, C. H., S. E. Randolph, and P. A. Nuttall. 1999. Ixodes ticks: serum species sensitivity of anticomplement activity. Exp. Parasitol. 93: 207-214.
5. Lawrie, C. H., R. B. Sim, and P. A. Nuttall. 2005. Investigation of the mechanisms of anti-complement activity in Ixodes ricinus ticks. Mol. Immunol. 42: 31-38.
6. Ribeiro, J. M. 1987. Ixodes dammini: salivary anti-complement activity. Exp. Parasitol. 64: 347-353.
7. Soares, C. A., C. M. Lima, M. C. Dolan, J. Piesman, C. B. Beard, and N. S. Zeidner. 2005. Capillary feeding of specific dsRNA induces silencing of the isac gene in nymphal Ixodes scapularis ticks. Insect Mol. Biol. 14: 443-452.
8. Ribeiro, J. M., F. Alarcon-Chaidez, I. M. Francischetti, B. J. Mans, T. N. Mather, J. G. Valenzuela, and S. K. Wikel. 2006. An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks. Insect Biochem. Mol. Biol. 36: 111-129.
9. Valenzuela, J. G., R. Charlab, T. N. Mather, and J. M. Ribeiro. 2000. Purification, cloning, and expression of a novel salivary anticomplement protein from the tick. Ixodes scapularis. J. Biol. Chem. 275: 18717-18723.
10. Tyson, K., C. Elkins, H. Patterson, E. Fikrig, and A. de Silva. 2007. Biochemical and functional characterization of Salp20, an Ixodes scapularis tick salivary protein that inhibits the complement pathway. Insect Mol. Biol. 16: 469-479.
11. Daix, V., H. Schroeder, N. Praet, J. P. Georgin, I. Chiappino, L. Gillet, K. de Fays, Y. Decrem, G. Leboulle, E. Godfroid, et al. 2007. Ixodes ticks belonging to the Ixodes ricinus complex encode a family of anticomplement proteins. Insect Mol. Biol. 16: 155-166.
12. Hourcade, D. E., L. M. Mitchell, and M. E. Medof. 1999. Decay acceleration of the complement alternative pathway C3 convertase. Immunopharmacology 42: 167-173.
13. McRae, J. L., T. G. Duthy, K. M. Griggs, R. J. Ormsby, P. J. Cowan, B. A. Cromer, W. J. McKinstry, M. W. Parker, B. F. Murphy, and D. L. Gordon. 2005. Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein. J. Immunol. 174: 6250-6256.
14. Zipfel, P. F., T. S. Jokiranta, J. Hellwage, V. Koistinen, and S. Meri. 1999. The factor H protein family. Immunopharmacology 42: 53-60.
15. Weiler, J. M., M. R. Daha, K. F. Austen, and D. T. Fearon. 1976. Control of the amplification convertase of complement by the plasma protein β1H. Proc. Natl. Acad. Sci. USA 73: 3268-3272.
16. Pangburn, M. K., R. D. Schreiber, and H. J. Muller-Eberhard. 1977. Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein β1H for cleavage of C3b and C4b in solution. J. Exp. Med. 146: 257-270.
17. Ross, G. D., J. D. Lambris, J. A. Cain, and S. L. Newman. 1982. Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity. J. Immunol. 129: 2051-2060.
18. Hourcade, D. E. 2006. The role of properdin in the assembly of the alternative pathway C3 convertases of complement. J. Biol. Chem. 281: 2128-2132.
19. Fearon, D. T., and K. F. Austen. 1975. Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase. J. Exp. Med. 142: 856-863.
20. Morgan, B. P., C. L. Harris. 1999. Complement regulatory proteins. Academic Press, San Diego.
21. Pangburn, M. K., and H. J. Muller-Eberhard. 1986. The C3 convertase of the alternative pathway of human complement: enzymic properties of the bimolecular proteinase. Biochem. J. 235: 723-730.
22. Fujita, T., T. Inoue, K. Ogawa, K. Iida, and N. Tamura. 1987. The mechanism of action of decay-accelerating factor (DAF): DAF inhibits the assembly of C3 convertases by dissociating C2a and Bb. J. Exp. Med. 166: 1221-1228.
23. Nicholson-Weller, A., J. Burge, D. T. Fearon, P. F. Weller, and K. F. Austen. 1982. Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system. J. Immunol. 129: 184-189.
24. Fearon, D. T. 1979. Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane. Proc. Natl. Acad. Sci. USA 76: 5867-5871.
25. Whaley, K., and S. Ruddy. 1976. Modulation of the alternative complement pathways by β1H globulin. J. Exp. Med. 144: 1147-1163.
26. Gupta-Bansal, R., J. B. Parent, and K. R. Brunden. 2000. Inhibition of complement alternative pathway function with anti-properdin monoclonal antibodies. Mol. Immunol. 37: 191-201.
27. Perdikoulis, M. V., U. Kishore, and K. B. Reid. 2001. Expression and characterisation of the thrombospondin type I repeats of human properdin. Biochim. Biophys. Acta 1548: 265-277.
28. Spitzer, D., L. M. Mitchell, J. P. Atkinson, and D. E. Hourcade. 2007. Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly. J. Immunol. 179: 2600-2608.
29. Tsao, N., W. H. Tsai, Y. S. Lin, W. J. Chuang, C. H. Wang, and C. F. Kuo. 2006. Streptococcal pyrogenic exotoxin B cleaves properdin and inhibits complement-mediated opsonophagocytosis. Biochem. Biophys. Res. Commun. 339: 779-784.
30. Goundis, D., and K. B. Reid. 1988. Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs. Nature 335: 82-85.
31. 4)β1-1 Cer] and has a sequence homology with other proteins that bind sulfated glycoconjugates. J. Biol. Chem. 265: 2852-2855.
32. Guo, N. H., H. C. Krutzsch, E. Negre, T. Vogel, D. A. Blake, and D. D. Roberts. 1992. Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin promote melanoma cell adhesion. Proc. Natl. Acad. Sci. USA 89: 3040-3044.
33. Tucker, R. P. 2004. The thrombospondin type 1 repeat superfamily. Int. J. Biochem. Cell Biol. 36: 969-974.
34. Couvreur B., J. Beaufays, C. Charon, K. Lahaye, F. Gensale, V. Denis, B. Charloteaux, Y. Decrem, P. P. Prévôt, M. Brossard, et al. 2008. Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus. PLoS ONE 3: el400.