Streptococcal pyrogenic exotoxin B cleaves properdin and inhibits complement-mediated opsonophagocytosis

Biochemical and Biophysical Research Communications

Volumn 339, Issue 3, 2006, Pages 779-784

  Tsao, Nina ^a   Tsai, Wan Hua ^b   Lin, Yee Shin ^b   Chuang, Woei Jer ^b   Wang, Chiou Huey ^c   Kuo, Chih Feng ^a  

^a I SHOU UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c E DA HOSPITAL   (Taiwan)

Author keywords

Alternative complement pathway; Neutrophil; Opsonophagocytosis; Properdin; Streptococcal pyrogenic exotoxin B

Indexed keywords

CYSTEINE PROTEINASE; PROPERDIN; PROTEINASE; STREPTOCOCCAL PYROGENIC EXOTOXIN B; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL KILLING; COMPLEMENT ALTERNATIVE PATHWAY; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NEUTROPHIL; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; STREPTOCOCCUS INFECTION; WESTERN BLOTTING;

ANIMALS; BINDING SITES; COMPLEMENT SYSTEM PROTEINS; CYSTEINE ENDOPEPTIDASES; ERYTHROCYTES; HUMANS; NEUTROPHILS; OPSONIN PROTEINS; PHAGOCYTOSIS; PROPERDIN; PROTEIN BINDING; RABBITS; STREPTOCOCCAL INFECTIONS;

ANIMALIA; STREPTOCOCCUS;

EID: 28844489094     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.11.078     Document Type: Article

References (38)

1. L.A. Cone, D.R. Woodard, P.M. Schlievert, and G.S. Tomory Clinical and bacteriologic observations of a toxic shock-like syndrome due to Streptococcus pyogenes N. Engl. J. Med. 317 1987 146 149
2. D.L. Stevens Invasive group A streptococcus infections Clin. Infect. Dis. 14 1992 2 13
3. D.L. Stevens The flesh-eating bacterium: What's next? J. Infect. Dis. 179 1999 S366 S374
4. H. Jarva, T.S. Jokiranta, R. Wurzner, and S. Meri Complement resistance mechanisms of streptococci Mol. Immunol. 40 2003 95 107
5. Y. Ji, L. McLandsborough, A. Kondagunta, and P.P. Cleary C5a peptidase alters clearance and trafficking of group A streptococci by infected mice Infect. Immun. 64 1996 503 510
6. B.A. Fernie-King, D.J. Seilly, C. Willers, R. Wurzner, A. Davies, and P.J. Lachmann Streptococcal inhibitor of complement (SIC) inhibits the membrane attack complex by preventing uptake of C567 onto cell membranes Immunology 103 2001 390 398
7. M.W. Cunningham Pathogenesis of group A streptococcal infections Clin. Microbiol. Rev. 13 2000 470 511
8. M. Collin, and A. Olsen Extracellular enzymes with immunomodulating activities: variations on a theme in Streptococcus pyogenes Infect. Immun. 71 2003 2983 2992
9. B. Lei, F.R. DeLeo, N.P. Hoe, M.R. Graham, S.M. Mackie, R.L. Cole, M. Liu, H.R. Hill, D.E. Low, M.J. Federle, J.R. Scott, and J.M. Musser Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis Nat. Med. 7 2001 1298 1305
10. U. von Pawel-Rammingen, B.P. Johansson, and L. Bjorck IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G EMBO J. 21 2002 1607 1615
11. U. von Pawel-Rammingen, and L. Bjorck IdeS and SpeB: immunoglobulin- degrading cysteine proteinases of Streptococcus pyogenes Curr. Opin. Microbiol. 6 2003 50 55
12. M. Collin, and A. Olsen Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins Infect. Immun. 69 2001 7187 7189
13. M. Collin, M.D. Svensson, A.G. Sjoholm, J.C. Jensenius, U. Sjobring, and A. Olsen EndoS and SpeB from Streptococcus pyogenes inhibit immunoglobulin- mediated opsonophagocytosis Infect. Immun. 70 2002 6646 6651
14. A. Eriksson, and M. Norgren Cleavage of antigen-bound immunoglobulin G by SpeB contributes to streptococcal persistence in opsonizing blood Infect. Immun. 71 2003 211 217
15. P.R. Hsueh, J.J. Wu, P.J. Tsai, J.W. Liu, Y.C. Chuang, and K.T. Luh Invasive group A streptococcal disease in Taiwan is not associated with the presence of streptococcal pyrogenic exotoxin genes Clin. Infect. Dis. 26 1998 584 589
16. B.K.G. Eriksson, J. Andersson, S.E. Holm, and M. Norgren Invasive group A streptococcal infections: T1M1 isolates expressing pyrogenic exotoxins A and B in combination with selective lack of toxin-neutralizing antibodies are associated with increased risk of streptococcal toxic shock syndrome J. Infect. Dis. 180 1999 410 418
17. H. Herwald, M. Collin, W. Muller-Esterl, and L. Bjorck Streptococcal cysteine proteinase releases kinins: a novel virulence mechanism J. Exp. Med. 184 1996 665 673
18. E.H. Burns Jr., A.M. Marciel, and J.M. Musser Activation of a 66-kilodalton human endothelial cell matrix metalloprotease by Streptococcus pyogenes extracellular cysteine protease Infect. Immun. 64 1996 4744 4750
19. B.B. Wolf, C.A. Gibson, V. Kapur, I.M. Hussaini, J.M. Musser, and S.L. Gonias Proteolytically active streptococcal pyrogenic exotoxin B cleaves monocytic cell urokinase receptor and releases an active fragment of the receptor from the cell surface J. Biol. Chem. 269 1994 30682 30687
20. V. Kapur, S. Topouzis, M.W. Majesky, L.L. Li, M.R. Hamrick, R.J. Hamill, J.M. Patti, and J.M. Musser A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin Microb. Pathog. 15 1993 327 346
21. V. Kapur, M.W. Majesky, L.L. Li, R.A. Black, and J.M. Musser Cleavage of interleukin 1β (IL-1β) precursor to produce active IL-1β by a conserved extracellular cysteine protease from Streptococcus pyogenes Proc. Natl. Acad. Sci. USA 90 1993 7676 7680
22. S. Lukomski, S. Sreevatsan, C. Amberg, W. Reichardt, M. Woischnik, A. Podbielski, and J.M. Musser Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains J. Clin. Invest. 99 1997 2574 2580
23. S. Lukomski, E.H. Burns Jr., P.R. Wyde, A. Podbielski, J. Rurangirwa, D.K. Moore-Poveda, and J.M. Musser Genetic inactivation of an extracellular cysteine protease (SpeB) expressed by Streptococcus pyogenes decreases resistance to phagocytosis and dissemination to organs Infect. Immun. 66 1998 771 776
24. S. Lukomski, C.A. Montgomery, J. Rurangirwa, R.S. Geske, J.P. Barrish, G.J. Adams, and J.M. Musser Extracellular cysteine protease produced by Streptococcus pyogenes participates in the pathogenesis of invasive skin infection and dissemination in mice Infect. Immun. 67 1999 1779 1788
25. C.F. Kuo, J.J. Wu, K.Y. Lin, P.J. Tsai, S.C. Lee, Y.T. Jin, H.Y. Lei, and Y.S. Lin Role of streptococcal pyrogenic exotoxin B in the mouse model of group A streptococcal infection Infect. Immun. 66 1998 3931 3935
26. C.F. Kuo, Y.H. Luo, H.Y. Lin, K.J. Huang, J.J. Wu, H.Y. Lei, M.T. Lin, W.J. Chuang, C.C. Liu, Y.T. Jin, and Y.S. Lin Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection Microb. Pathog. 36 2004 273 285
27. W.J. Schwaeble, and K.B.M. Reid Does properdin crosslink the cellular and the humoral immune response? Immunol. Today 20 1999 17 21
28. J.E. Figueroa, and P. Densen Infectious diseases associated with complement deficiencies Clin. Microbiol. Rev. 4 1991 359 395
29. C.Y. Chen, S.C. Luo, C.F. Kuo, Y.S. Lin, J.J. Wu, M.T. Lin, C.C. Liu, W.Y. Jeng, and W.J. Chuang Maturation processing and characterization of streptopain J. Biol. Chem. 278 2003 17336 17343
30. P.C. Giclas Alternative pathway evaluation J.E. Coligan A.M. Kruisbeek D.H. Margulies E.M. Shevach W. Strober Current Protocols in Immunology 1999 Wiley New York 13.2.1 13.2.9
31. J.H. Braconier, H. Odeberg, and A.G. Sjoholm Granulocyte phagocytosis of Streptococcus pneumoniae in properdin-deficient serum Infect. Immun. 40 1983 219 224
32. Y.V. Matsuka, S. Pillai, S. Gubba, J.M. Musser, and S.B. Olmsted Fibrinogen cleavage by the Streptococcus pyogenes extracellular cysteine protease and generation of antibodies that inhibit enzyme proteolytic activity Infect. Immun. 67 1999 4326 4333
33. C.F. Kuo, J.J. Wu, P.J. Tsai, F.J. Kao, H.Y. Lei, M.T. Lin, and Y.S. Lin Streptococcal pyrogenic exotoxin B induces apoptosis and reduces phagocytic activity in U937 cells Infect. Immun. 67 1999 126 130
34. L. Wei, V. Pandiripally, E. Gregory, M. Clymer, and D. Cue Impact of the SpeB protease on binding of the complement regulatory proteins factor H and factor H-like protein 1 by Streptococcus pyogenes Infect. Immun. 73 2005 2040 2050
35. M. Bongrazio, A.R. Pries, and A. Zakrzewicz The endothelium as physiological source of properdin: role of wall shear stress Mol. Immunol. 39 2003 669 675
36. K. Berggard, E. Johnsson, E. Morfeldt, J. Persson, M. Stalhammar-Carlemalm, and G. Lindahl Binding of human C4BP to the hypervariable region of M protein: a molecular mechanism of phagocytosis resistance in Streptococcus pyogenes Mol. Microbiol. 42 2001 539 551
37. F. Carlsson, C. Sandin, and G. Lindahl Human fibrinogen bound to Streptococcus pyogenes M protein inhibits complement deposition via the classical pathway Mol. Micribiol. 56 2005 28 39
38. M. Nilsson, M. Weineisen, T. Andersson, L. Truedsson, and U. Sjobring Critical role for complement receptor 3 (CD11b/CD18), but not for Fc receptors, in killing of Streptococcus pyogenes by neutrophils in human immune serum Eur. J. Immunol. 35 2005 1472 1481