Toona sinensis Roem (Meliaceae) leaf extract alleviates hyperglycemia via altering adipose glucose transporter 4

Food and Chemical Toxicology

Volumn 46, Issue 7, 2008, Pages 2554-2560

  Wang, Pei Hwei ^a   Tsai, May Jywan ^b   Hsu, Chia Yu ^c   Wang, Chia Yi ^c   Hsu, Hseng Kuang ^a   Weng, Ching Feng ^c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL DONG HWA UNIVERSITY   (Taiwan)

Author keywords

Alloxan; Diabetes; Glucose transporter 4; Hypoglycemia; Insulin; Toona sinensis Roem (Meliaceae)

Indexed keywords

ALCOHOL; GLIBENCLAMIDE; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; MESSENGER RNA; PLANT EXTRACT; TOONA SINENSIS EXTRACT; WATER;

ADIPOSE TISSUE; ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; FEMALE; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; MALE; MELIACEAE; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; TOONA SINENSIS; WESTERN BLOTTING;

ADIPOSE TISSUE; ANIMALS; AREA UNDER CURVE; BLOOD GLUCOSE; BLOTTING, WESTERN; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION REGULATION; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORTER TYPE 4; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; MELIACEAE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RANDOM ALLOCATION; RATS; RATS, LONG-EVANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

MELIACEAE; RATTUS; TOONA SINENSIS;

EID: 44749085842     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.04.011     Document Type: Article

References (60)

1. Abel E.D., Peroni O., Kim J.K., Kim Y.B., Boss O., Hadro E., Minnemann T., Shulman G.I., and Kahn B.B. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409 (2001) 729-733
2. Andersen P.H., Lund S., Vestergaard H., Junker S., Kahn B.B., and Pedersen O. Expression of the major insulin regulatable glucose transporter (GLUT4) in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion. J. Clin. Endocrinol. Metab. 77 (1993) 27-32
3. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
4. Buse J.B., Yasuda K., Lay T.P., Seo T.S., Olson A.L., Pessin J.E., Karam J.H., Seino S., and Bell G.I. Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation. Diabetes 41 (1992) 1436-1445
5. Chang H.C., Hung W.C., Huang M.S., and Hsu H.K. Extract from the leaves of Toona sinensis Roemor exerts potent antiproliferative effect on human lung cancer cells. Am. J. Chin. Med. 30 (2002) 307-314
6. Chang H.L., Hsu H.K., Su J.H., Wang P.H., Chung Y.F., Chia Y.C., Tsai L.Y., Wu Y.C., and Yuan S.S. The fractionated Toona sinensis leaf extract induces apoptosis of human ovarian cancer cells and inhibits tumor growth in a murine xenograft model. Gynecol. Oncol. 102 (2006) 309-314
7. Charron M.J., Katz E.B., and Olson A.L. GLUT4 gene regulation and manipulation. J. Biol. Chem. 274 (1999) 3253-3256
8. Chia, Y.C., 2005. A study on the isolation of antitumor compound from Toona sinensis Roemor. Report of Health Food Project (in Chinese).
9. Cho E.J., Yokozawa T., Rhyu D.Y., Kim H.Y., Shibahara N., Park J.C., et al. The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation. Am. J. Chin. Med. 31 (2003) 907-917
10. Cho E.J., Yokozawa T., Rhyu D.Y., Kim S.C., Shibahara N., Park J.C., et al. Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl-2-picrylhydrazyl radical. Phytomedicine 10 (2003) 544-551
11. Chopra M., Galbraith S., and Darnton-Hill I. A global response to a global problem: the epidemic of overnutrition. Bull. World Health Organ. 80 (2002) 952-958
12. DeFronzo R.A., and Simonson D.C. Oral sulfonylurea agents suppress hepatic glucose production in non-insulin-dependent diabetic individuals. Diabetes Care 7 Suppl. 1 (1984) 72-80
13. DeFronzo R.A., Bonadonna R.C., and Ferrannini E. Pathogenesis of NIDDM A balanced overview. Diabetes Care 15 (1992) 318-368
14. Ducluzeau P.H., Perretti N., Laville M., Andreelli F., Vega N., Riou J.P., and Vidal H. Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes. Diabetes 50 (2001) 1134-1142
15. Edmonds J.M., and Staniforth M. Toona sinensis (Meliaceae). Curtis' Bot. Mag. 15 (1998) 186-193
16. Ezaki O. Regulatory elements in the insulin-responsive glucose transporter (GLUT4) gene. Biochem. Biophys. Res. Commun. 241 (1997) 1-6
17. Fan S., Chen H.N., Wang C.J., Tseng W.C., Hsu H.K., and Weng C.F. Toona sinensis Roemor (Meliaceae) leaf extract alleviates liver fibrosis via reducing TGFbeta1 and collagen. Food Chem. Toxicol. 45 (2007) 2228-2236
18. Furuta M., Yano Y., Gabazza E.C., Araki-Sasaki R., Tanaka T., Katsuki A., Hori Y., Nakatani K., Sumida Y., and Adachi Y. Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus. Diabetes Res. Clin. Pract. 56 (2002) 159-171
19. Galato D., Ckless K., Susin M.F., Giacomelli C., Ribeiro-do-Valle R.M., and Spinelli A. Antioxidant capacity of phenolic and related compounds: correlation among electrochemical, visible spectroscopy methods and structure-antioxidant activity. Redox Rep. 6 (2001) 243-250
20. Gali H.U., Perchellet E.M., and Perchellet J.P. Inhibition of tumor promoter-induced ornithine decarboxylase activity by tannic acid and other polyphenols in mouse epidermis in vivo. Cancer Res. 51 (1991) 2820-2825
21. Gali H.U., Perchellet E.M., Klish D.S., Johnson J.M., and Perchellet J.P. Antitumor-promoting activities of hydrolyzable tannins in mouse skin. Carcinogenesis 13 (1992) 715-718
22. Garvey W.T., Huecksteadt T.P., and Birnbaum M.J. Pretranslational suppression of an insulin-responsive glucose transporter in rats with diabetes mellitus. Science 245 (1989) 60-63
23. Garvey W.T., Maianu L., Huecksteadt T.P., Birnbaum M.J., Molina J.M., and Ciaraldi T.P. Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity. J. Clin. Invest. 87 (1991) 1072-1081
24. Garvey W.T., Maianu L., Hancock J.A., Golichowski A.M., and Baron A. Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM. Diabetes 41 (1992) 465-475
25. Gloyn A.L. The search for type 2 diabetes genes. Ageing Res. Rev. 2 (2003) 111-127
26. Hseu Y.C., Chang W.H., Chen C.S., Liao J.W., Huang C.J., Lu F.J., Chia Y.C., Hsu H.K., Wu J.J., and Yang H.L. Antioxidant activities of Toona sinensis leaves extracts using different antioxidant models. Food Chem. Toxicol. 46 (2008) 105-114
27. Hsieh T.J., Chen C.Y., Kuo R.Y., Chang F.R., and Wu Y.C. Two new alkaloids from artabotrys uncinatus. J. Nat. Prod. 62 (1999) 1192-1193
28. Hsieh T.J., Liu T.Z., Chia Y.C., Chern C.L., Lu F.J., Chuang M.C., Mau S.Y., Chen S.H., Syu Y.H., and Chen C.H. Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cells. Food Chem. Toxicol. 42 (2004) 843-850
29. Hsieh C.L., Lin Y.C., Ko W.S., Peng C.H., Huang C.N., and Peng R.Y. Inhibitory effect of some selected nutraceutic herbs on LDL glycation induced by glucose and glyoxal. J. Ethnopharmacol. 102 (2005) 357-363
30. Hsu H.K., Yang Y.C., Hwang J.H., and Hong S.J. Effects of Toona sinensis leaf extract on lipolysis in differentiated 3T3-L1 adipocytes. Kaohsiung J. Med. Sci. 19 (2003) 385-390
31. Jones J.P., and Dohm G.L. Regulation of glucose transporter GLUT-4 and hexokinase II gene transcription by insulin and epinephrine. Am. J. Physiol. 273 (1997) E682-E687
32. Kern M., Loomis T.A., Tapscott E.B., and Dohm G.L. Increased muscle glucose uptake in response to chronic glyburide treatment is not related to changes in glucose transporter (GLUT4) protein. Int. J. Biochem. 25 (1993) 1257-1261
33. Lebovitz H.E. Oral hypoglycemic agents. In: Rifkin H., and Porte D. (Eds). Ellenberg and Rifkin's Diabetes mellitus Theory and Practise (1990), Elsevier, New York 554-574
34. Liao J.W., Hsu C.K., Wang M.F., Hsu W.M., and Chan Y.C. Beneficial effect of Toona sinensis Roemor on improving cognitive performance and brain degeneration in senescence-accelerated mice. Br. J. Nutr. 96 (2006) 400-407
35. Liao J.W., Chung Y.C., Yeh J.Y., Lin Y.C., Lin Y.G., Wu S.M., and Chan Y.C. Safety evaluation of water extracts of Toona sinensis Roemor leaf. Food Chem. Toxicol. 45 (2007) 1393-1399
36. Luo X.D., Wu S.H., Ma Y.B., and Wu D.G. Limonoids and phytol derivatives from Cedrela sinensis. Fitoterapia 71 (2000) 492-496
37. Mei L., McClements D.J., and Decker E.A. Lipid oxidation in emulsions as affected by charge status of antioxidants and emulsion droplets. J. Agric. Food Chem. 47 (1999) 2267-2273
38. Mitsui K., Maejima M., Fukaya H., Hitotsuyanagi Y., and Takeya K. Limonoids from Cedrela sinensis. Phytochemistry 65 (2004) 3075-3081
39. Mohammad S., Taha A., Bamezai R.N., and Baquer N.Z. Modulation of glucose transporter (GLUT4) by vanadate and Trigonella in alloxan-diabetic rats. Life Sci. 78 (2006) 820-824
40. Müller G., and Geisen K. Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at adipocytes. Horm. Metab. Res. 28 (1996) 469-487
41. Munoz P., Chillaron J., Camps M., Castello A., Furriols M., Testar X., Palacin M., and Zorzano A. Evidence for posttranscriptional regulation of GLUT4 expression in muscle and adipose tissue from streptozotocin-induced diabetic and benfluorex-treated rats. Biochem. Pharmacol. 52 (1996) 1665-1673
42. Nakayama T., Hiramitsu M., Osawa T., and Kawakishi S. The protective role of gallic acid esters in bacterial cytotoxicity and SOS responses induced by hydrogen peroxide. Mutat. Res. 303 (1993) 29-34
43. Neufer P.D., Carey J.O., and Dohm G.L. Transcriptional regulation of the gene for glucose transporter GLUT4 in skeletal muscle. Effects of diabetes and fasting. J. Biol. Chem. 268 (1993) 13824-13829
44. O'Rahilly S. Diabetes in midlife: planting genetic time bombs. Nat. Med. 3 (1997) 1080-1081
45. Park B.H., Rho H.W., Park J.W., Cho C.G., Kim J.S., Chung H.T., and Kim H.R. Protective mechanism of glucose against alloxan-induced pancreatic beta-cell damage. Biochem. Biophys. Res. Commun. 210 (1995) 1-6
46. Perry L.I. Medical plants of east and south-east Asia: attributed properties and uses. Mol. Med. (1980) 263
47. Poon S.L., Leu S.F., Hsu H.K., Liu M.Y., and Huang B.M. Regulatory mechanism of Toona sinensis on mouse leydig cell steroidogenesis. Life Sci. 76 (2005) 1473-1487
48. 2+, common signals for apoptosis induced by gallic acid. Biochem. Pharmacol. 55 (1998) 1973-1981
49. Saravanan R., and Pari L. Antihyperlipidemic and antiperoxidative effect of diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats. BMC Complement. Alternat. Med. 5 (2005) 1-10
50. Serrano A., Palacios C., Roy G., Cespon C., Villar M.L., Nocito M., and Gonzalez-Porque P. Derivatives of gallic acid induce apoptosis in tumoral cell lines and inhibit lymphocyte proliferation. Arch. Biochem. Biophys. 350 (1998) 49-54
51. Singleton V.L. Naturally occurring food toxicants: phenolic substances of plant origin common in foods. Adv. Food Res. 27 (1981) 149-242
52. Tsai I.L., Jeng Y.F., Duh C.Y., and Chen I.S. Cytotoxic constituents from the leaves of Litsea akoensis. Chin. Pharm. J. 53 (2001) 291-301
53. Turner R.C., Hattersley A.T., Shaw J.T., and Levy J.C. Type II diabetes: clinical aspects of molecular biological studies. Diabetes 44 (1995) 1-10
54. Watson R.T., and Pessin J.E. Subcellular compartmentalization and trafficking of the insulin-responsive glucose transporter, GLUT4. Exp. Cell Res. 271 (2001) 75-83
55. Westenburg H.E., Lee K.J., Lee S.K., Fong H.H., van Breemen R.B., Pezzuto J.M., and Kinghorn A.D. Activity-guided isolation of antioxidative constituents of Cotinus coggygria. J. Nat. Prod. 63 (2000) 1696-1698
56. Wu J., Sugiyama H., Zeng L.H., Mickle D., and Wu T.W. Evidence of Trolox and some gallates as synergistic protectors of erythrocytes against peroxyl radicals. Biochem. Cell Biol. 76 (1998) 661-664
57. Yang Y.C., Hsu H.K., Hwang J.H., and Hong S.J. Enhancement of glucose uptake in 3T3-L1 adipocytes by Toona sinensis leaf extract. Kaohsiung J. Med. Sci. 19 (2003) 327-333
58. Yki-Jarvinen H. Pathogenesis of non-insulin-dependent diabetes mellitus. Lancet 343 (1994) 91-95
59. Yun B.S., Lee I.K., Kim J.P., Chung S.H., Shim G.S., and Yoo I.D. Lipid peroxidation inhibitory activity of some constituents isolated from the stem bark of Eucalyptus globulus. Arch. Pharm. Res. 23 (2000) 147-150
60. Zisman A., Peroni O.D., Abel E.D., Michael M.D., Mauvais-Jarvis F., Lowell B.B., Wojtaszewski J.F., Hirshman M.F., Virkamaki A., Goodyear L.J., Kahn C.R., and Kahn B.B. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat. Med. 6 (2000) 924-928