NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 5, 2008, Pages 1827-1835

  Lee, Joon H ^a   Kim, Min ^b   Im, Young Sun ^b   Choi, Wungrak ^b   Byeon, Suk Ho ^b   Lee, Hyung Keun ^b,c  

^a Konyang University   (South Korea)

^b Institute of Vision Research   (South Korea)

^c Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT5; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; NFAT5 PROTEIN, HUMAN; SODIUM CHLORIDE; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; CELL DEATH; CELL NUCLEUS; CELL SURVIVAL; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA LIMBUS; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIUM CELL; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPEROSMOLARITY; IMMUNOCYTOCHEMISTRY; INTRACELLULAR TRANSPORT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; BIOSYNTHESIS; CYTOLOGY; DNA MICROARRAY; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; GENETICS; METABOLISM; OSMOTIC PRESSURE; PHYSIOLOGY;

APOPTOSIS; BLOTTING, WESTERN; CELL NUCLEUS; ENZYME INHIBITORS; EPITHELIAL CELLS; EPITHELIUM, CORNEAL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; INTERLEUKIN-1BETA; LIMBUS CORNEAE; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSMOTIC PRESSURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN TRANSPORT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SALINE SOLUTION, HYPERTONIC; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 44649189409     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-1142     Document Type: Article

References (49)

1. Aramburu J, Drews-Elger K, Estrada-Gelonch A, et al. Regulation of the hypertonic stress response and other cellular functions by the Rel-like transcription factor NFAT5. Biochem Pharmacol. 2006; 72:1597-1604.
2. Ko BC, Lam AK, Kapus A, Fan L, Chung SK, Chung SS. Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP). J Biol Chem. 2002; 277:46085-46092.
3. Lopez-Rodriguez C, Aramburu J, Jin L, Rakeman AS, Michino M, Rao A. Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress. Immunity. 2001;15:47-58.
4. Li DQ, Luo L, Chen Z, Kim HS, Song XJ, Pflugfelder SC. JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells. Exp Eye Res. 2006;82:588-596.
5. Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2004;45:4302-4311.
6. Gilbard JP, Carter JB, Sang DN, Refojo MF, Hanninen LA, Kenyon KR. Morphologic effect of hyperosmolarity on rabbit corneal epithelium. Ophthalmology. 1994;91:1205-1212.
7. Luo L, Li DQ, Pflugfelder SC. Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways. Cornea. 2007;26:452-460.
8. Ho SN. The role of NFAT5/TonEBP in establishing an optimal intracellular environment. Arch Biochem Biophys. 2003;413:151-157.
9. Woo SK, Lee SD, Kwon HM. TonEBP transcriptional activator in the cellular response to increased osmolality. Pflugers Arch. 2002;444:579-585.
10. Ko BC, Turck CW, Lee KW, Yang Y, Chung SS. Purification, identification, and characterization of an osmotic response element binding protein. Biochem Biophys Res Commun. 2000;270: 52-61.
11. Tsytsykova AV, Goldfeld AE. Inducer-specific enhanceosome formation controls tumor necrosis factor alpha gene expression in T lymphocytes. Mol Cell Biol. 2002;22:2620-2631.
12. Goldfeld AE, McCaffrey PG, Strominger JL, Rao A. Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter. J Exp Med. 1993;178:1365-1379.
13. Hoey T, Sun YL, Williamson K, Xu X. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity. 1995;2:461-472.
14. Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol. 1997;15:707-747.
15. Ho SN. Intracellular water homeostasis and the mammalian cellular osmotic stress response. J Cell Physiol. 2006;206:9-15.
16. Ito T, Fujio Y, Hirata M, et al. Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells. Biochem J. 2004;382:177-182.
17. Miyakawa H, Woo SK, Dahl SC, Handler JS, Kwon HM. Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity. Proc Natl Acad Sci USA. 1999;96:2538-2542.
18. Bosman DK, Deutz NE, Maas MA, et al. Amino acid release from cerebral cortex in experimental acute liver failure, studied by in vivo cerebral cortex microdialysis. J Neurochem. 1992;59:591-599.
19. Rim JS, Atta MG, Dahl SC, Berry GT, Handler JS, Kwon HM. Transcription of the sodium/myo-inositol cotransporter gene is regulated by multiple tonicity-responsive enhancers spread over 50 kilobase pairs in the 5'-flanking region. J Biol Chem. 1998;273: 20615-20621.
20. Woo SK, Lee SD, Na KY, Park WK, Kwon HM. TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicity. Mol Cell Biol. 2002;22:5753-5760.
21. Kojima R, Randall JD, Ito E, Manshio H, Suzuki Y, Gullans SR. Regulation of expression of the stress response gene, Osp94: identification of the tonicity response element and intracellular signalling pathways. Biochem J. 2004;380:783-794.
22. Lopez-Rodriguez C, Antos CL, Shelton JM, et al. Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci USA. 2004;101:2392-2397.
23. Lee HK, Lee JH, Kim M, Kariya Y, Miyazaki K, Kim EK. Insulin-like growth factor-1 induces migration and expression of laminin-5 in cultured human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2006;47:873-882.
24. Narayanan S, Manning J, Proske R, McDermott AM. Effect of hyperosmolality on beta-defensin gene expression by human corneal epithelial cells. Cornea. 2006;25:1063-1068.
25. Neuringer IP, Sloan J, Budd S, et al. Calcineurin inhibitor effects on growth and phenotype of human airway epithelial cells in vitro. Am J Transplant. 2005;5:2660-2670.
26. Ferraris JD, Persaud P, Williams CK, Chen Y, Burg MB. cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein. Proc Natl Acad Sci USA. 2002;99:16800-16805.
27. Irarrazabal CE, Liu JC, Burg MB, Ferraris JD. ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP. Proc Natl Acad Sci USA. 2004;101:8809-8814.
28. Nakano H. Signaling crosstalk between NF-kappaB and JNK. Trends Immunol. 2004;25:402-405.
29. Chang EJ, Im YS, Kay ED, Lee JE, Lee HK. The role of nerve growth factor in hyperosmolar stress induced apoptosis. J Cell Physiol. 2008;Feb 25 [Epub ahead of print].
30. Capo-Aponte JE, Wang Z, Bildin VN, et al. Functional and molecular characterization of multiple K-Cl cotransporter isoforms in corneal epithelial cells. Exp Eye Res. 2007;84:1090-1103.
31. Pan Z, Capo-Aponte JE, Zhang F, Wang Z, Pokorny KS, Reinach PS. Differential dependence of regulatory volume decrease behavior in rabbit corneal epithelial cells on MAPK superfamily activation. Exp Eye Res. 2007;84:978-990.
32. Tokiwa G, Dikic I, Lev S, Schlessinger J. Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science. 1996;273:792-794.
33. Malek AM, Goss GG, Jiang L, Izumo S, Alper SL. Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells. Stroke. 1998;29:2631-2640.
34. King CR, Borrello I, Porter L, Comoglio P, Schlessinger J. Ligand-independent tyrosine phosphorylation of EGF receptor and the erbB-2/neu proto-oncogene product is induced by hyperosmotic shock. Oncogene. 1989;4:13-18.
35. Kapus A, Szaszi K, Sun J, Rizoli S, Rotstein OD. Cell shrinkage regulates Src kinases and induces tyrosine phosphorylation of cortactin, independent of the osmotic regulation of Na+/H+ exchangers. J Biol Chem. 1999;274:8093-8102.
36. Bell LM, Leong ML, Kim B, et al. Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway. J Biol Chem. 2000;275:25262-25272.
37. Leong ML, Maiyar AC, Kim B, O'Keeffe BA, Firestone GL. Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J Biol Chem. 2003;278: 5871-5882.
38. Clerk A, Sugden PH. Activation of p21-activated protein kinase alpha (alpha PAK) by hyperosmotic shock in neonatal ventricular myocytes. FEBS Lett. 1997;403:23-25.
39. Schliess F, Heinrich S, Haussinger D. Hyperosmotic induction of the mitogen-activated protein kinase phosphatase MKP-1 in H4IIE rat hepatoma cells. Arch Biochem Biophys. 1998;351:35-40.
40. Duzgun SA, Rasque H, Kito H, et al. Mitogen-activated protein phosphorylation in endothelial cells exposed to hyperosmolar conditions. J Cell Biochem. 2000;76:567-571.
41. Dmitrieva NI, Cai Q, Burg MB. Cells adapted to high NaCl have many DNA breaks and impaired DNA repair both in cell culture and in vivo. Proc Natl Acad Sci USA. 2004;101:2317-2322.
42. Bildin VN, Wang Z, Iserovich P, Reinach PS. Hypertonicity-induced p38MAPK activation elicits recovery of corneal epithelial cell volume and layer integrity. J Membr Biol. 2003;193:1-13.
43. Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 2001;104:487-501.
44. Dinarello CA. The IL-1 family and in flammatory diseases. Clin Exp Rheumatol. 2002;20:S1-S13.
45. Creagh EM, Conroy H, Martin SJ. Caspase-activation pathways in apoptosis and immunity. Immunol Rev. 2003;193:10-21.
46. Ritchie MH, Fillmore RA, Lausch RN, Oakes JE. A role for NF-kappa B binding motifs in the differential induction of chemokine gene expression in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2004;45:2299-2305.
47. McDermott AM, Redfern RL, Zhang B, Pei Y, Huang L, Proske RJ. Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2003;44:1859-1865.
48. Lemp MA. Report of the national eye institute/industry workshop on the clinical trials in dry eyes. CLAO J. 1995;21:221-228.
49. Gilbard JP, Farris RL, Santa Maria J II. Osmolarity of tear micro volumes in keratoconjunctivitis sicca. Arch Ophthalmol. 1978;96:677- 681.