Purkinje-cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants

Journal of Neuroscience

Volumn 28, Issue 18, 2008, Pages 4640-4648

  Hurlock, Edward C ^a   McMahon, Anne ^a   Joho, Rolf H ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Burst firing; Cerebellum; Complex spike; K channels; Motor dysfunction; Purkinje cell

Indexed keywords

PROTEIN KV3.3; SHAW POTASSIUM CHANNEL; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN; KCNC3 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; ELECTROPHYSIOLOGY; MEMBRANE STEADY POTENTIAL; MOTOR COORDINATION; MOTOR PERFORMANCE; MOUSE; MUSCLE TWITCH; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PURKINJE CELL; ACTION POTENTIAL; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL BEHAVIOR; BODY EQUILIBRIUM; C57BL MOUSE; CYTOLOGY; ELECTROSTIMULATION; FEMALE; GENE EXPRESSION; GENETICS; MALE; METABOLISM; METHODOLOGY; MOUSE MUTANT; MUTATION; PATCH CLAMP; PHYSIOLOGY; RADIATION EXPOSURE; RADIATION RESPONSE;

ACTION POTENTIALS; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC STIMULATION; FEMALE; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR SKILLS; MUSCULOSKELETAL EQUILIBRIUM; MUTATION; PATCH-CLAMP TECHNIQUES; PURKINJE CELLS; SHAW POTASSIUM CHANNELS;

EID: 44649133392     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5486-07.2008     Document Type: Article

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