What do complex spikes signal about limb movements?

Annals of the New York Academy of Sciences

Volumn 978, Issue , 2002, Pages 205-218

  Ebner, Timothy J ^a   Johnson, Michael T V ^a   Roitman, Alexander ^a   Fu, Qinggong ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Climbing fiber; Complex spike; Direction; Limb movements; Purkinje cells; Pursuit tracking; Speed

Indexed keywords

ANALYTIC METHOD; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; CEREBELLUM; CLIMBING FIBER; CONFERENCE PAPER; ERROR; EXPERIMENTAL MODEL; FEMALE; INFORMATION; LIMB MOVEMENT; MONKEY; MOVEMENT (PHYSIOLOGY); NONHUMAN; PURKINJE CELL; SPIKE; TASK PERFORMANCE;

ANIMALIA;

EID: 0036965327     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb07568.x     Document Type: Conference Paper

References (35)

1. KEATING, J.G. & W.T. THACH. 1995. Nonclock behavior of inferior olive neurons: interspike interval of Purkinje cell complex spike discharge in the awake behaving monkey is random. J. Neurophysiol. 73: 1329-1340.
2. ITO, M. 2001. Cerebellar long-term depression: characterization, signal transduction, and functional roles. Physiol. Rev. 81: 1143-1195.
3. EBNER, T.J. & J.R. BLOEDEL. 1987. Climbing fiber afferent system: intrinsic properties and role in cerebellar information processing. In New Concepts in Cerebellar Neurobiology. J.S. King, Ed.: 371-386. Alan R. Liss, Inc. New York.
4. ITO, M., M. SAKURAI & P. TONGROACH. 1982. Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells. J. Physiol. 324: 113-134.
5. SASAKI, K., J.M. BOWER & R. LLINÁS. 1989. Multiple Purkinje cell recording in rodent cerebellar cortex. Eur. J. Neurosci. 1: 572-586.
6. WELSH, J.P., E.J. LANG, I. SUGIHARA, et al. 1995. Dynamic organization of motor control within the olivocerebellar system. Nature 374: 453-457.
7. GRAF, W., J.I. SIMPSON & C.S. LEONARD. 1988. Spatial organization of visual messages of the rabbit's cerebellar flocculus. II. Complex and simple spike responses of Purkinje cells. J. Neurophysiol. 60: 2091-2121.
8. STONE, L.S. & S.G. LISBERGER. 1990. Visual responses of Purkinje cells in the cerebellar flocculus during smooth-pursuit eye movements in monkeys. I. Simple spikes. J. Neurophysiol. 63: 1241-1261.
9. OJAKANGAS, C.L. & T.J. EBNER. 1992. Purkinje cell complex and simple spike changes during a voluntary arm movement learning task in the monkey. J. Neurophysiol. 68: 2222-2236.
10. KOBAYASHI, Y., K. KAWANO, A. TAKEMURA, et al. 1998. Temporal firing patterns of Purkinje cells in the cerebellar ventral paraflocculus during ocular following responses in monkeys II. Complex spikes. J. Neurophysiol. 80: 832-848.
11. KITAZAWA, S., T. KIMURA & P.B. YIN. 1998. Cerebellar complex spikes encode both destinations and errors in arm movements. Nature 392: 494-497.
12. WEST, G.A., D.R. HAYNOR, R. GOODKIN, et al. 1994. Magnetic resonance imaging signal changes in denervated muscles after peripheral nerve injury. Neurosurgery 35: 1077-1086.
13. APPS, R. 2000. Gating of climbing fibre input to cerebellar cortical zones. Prog. Brain Res. 124: 201-211.
14. GELLMAN, R., A.R. GIBSON & J.C. HOUK. 1985. Inferior olivary neurons in the awake cat: detection of contact and passive body displacement. J. Neurophysiol. 54: 40-60.
15. RUSHMER, D.S., W.J. ROBERTS & G.K. ANGTER. 1976. Climbing fiber responses of cerebellar Purkinje cells to passive movement of the cat forepaw. Brain Res. 106: 1-20.
16. HORN, K.M., P.L. VAN KAN & A.R. GIBSON. 1996. Reduction of rostral dorsal accessory olive responses during reaching. J. Neurophysiol. 76: 4140-4151.
17. BAUSWEIN, E., F.P. KOLB, B. LEIMBECK, et al. 1983. Simple and complex spike activity of cerebellar Purkinje cells during active and passive movements in the awake monkey. J. Physiol. 339: 379-394.
18. MANO, N.-I., I. KANAZAWA & K.-I. YAMAMOTO. 1986. Complex-spike activity of cerebellar Purkinje cells related to wrist tracking movement in the monkey. J. Neurophysiol. 56: 137-158.
19. OJAKANGAS, C.L. & T.J. EBNER. 1994. Purkinje cell complex spike activity during voluntary motor learning: relationship to kinematics. J. Neurophysiol. 72: 2617-2630.
20. FU, Q.-G., C.R. MASON, D. FLAMENT, et al. 1997. Movement kinematics encoded in complex spike discharge of primate cerebellar Purkinje cells. NeuroReport 8: 523-529.
21. WANG, J.-J., J.H. KIM & T.J. EBNER. 1987. Climbing fiber afferent modulation during a visually guided, multi-joint arm movement in the monkey. Brain Res. 410: 323-329.
22. LLINÁS, R. & K. SASAKI. 1989. The functional organization of the olivo-cerebellar system as examined by multiple Purkinje cell recordings. Eur. J. Neurosci. 1: 587-602.
23. LANG, E.J., I. SUGIHARA & R. LLINÁS. 1996. GABAergic modulation of complex spike activity by the cerebellar nucleoolivary pathway in rat. J. Neurophysiol. 76: 255-275.
24. COLTZ, J.D., M.T.V. JOHNSON & T. EBNER. 1999. Cerebellar Purkinje cell simple spike discharge encodes movement velocity in primates during visuomotor arm tracking. J. Neurosci. 19: 1782-1803.
25. CAMERON, A.C. 1998. Regression Analysis of Count Data. Cambridge. New York.
26. AGRESTI, A. 1996. An Introduction to Categorical Data Analysis. Wiley. New York.
27. GEORGOPOULOS, A.P., J.F. KALASKA, R. CAMINITI, et al. 1982. On the relations between the direction of two-dimensional arm movements and cell discharge in primate motor cortex. J. Neurosci. 2: 1527-1537.
28. FU, Q.-G., J.I. SUAREZ & T.J. EBNER. 1993. Neuronal specification of direction and distance during reaching movements in the superior precentral premotor area and primary motor cortex of monkeys. J. Neurophysiol. 70: 2097-2116.
29. SAINBURG, R.L., M.F. GHILARDI, H. POIZNER, et al. 1995. Control of limb dynamics in normal subjects and patients without proprioception. J. Neurophysiol. 73: 820-835.
30. FU, Q.-G., D. FLAMENT, J.D. COLTZ, et al. 1997. Relationship of cerebellar Purkinje cell simple spike discharge to movement kinematics in the monkey. J. Neurophysiol. 78: 478-491.
31. BELTON, T., M. SUH & J.I. SIMPSON. 2001. The non-visual complex spike signal in the flocculus responds to challenges to the vestibulo-ocular reflex gain. Soc. Neurosci. Abstr. 27: 70.9.
32. FORTIER, P.A., J.F. KALASKA & A.M. SMITH. 1989. Cerebellar neuronal activity related to whole-arm reaching movements in the monkey. J. Neurophysiol. 62: 198-210.
33. EBNER, T.J. & J.R. BLOEDEL. 1981. Role of climbing fiber afferent input in determining responsiveness of Purkinje cells to mossy fiber inputs. J. Neurophysiol. 45: 962-971.
34. ITO, M. 1989. Long-term depression. Annu. Rev. Neurosci. 12: 85-102.
35. GILBERT, P.F.C. & W.T. THACH. 1977. Purkinje cell activity during motor learning. Brain Res. 128: 309-328.