Pleiotropic effects of a disrupted K+ channel gene: Reduced body weight, impaired motor skill and muscle contraction, but no seizures

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 4, 1997, Pages 1533-1538

  Ho, Chi Shun ^a   Grange, Robert W ^a   Joho, Rolf H ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CELL VIABILITY; CONTROLLED STUDY; GENE DISRUPTION; INTERNEURON; MEMBRANE STEADY POTENTIAL; MOTOR PERFORMANCE; MOUSE; MULTIGENE FAMILY; MUSCLE CONTRACTILITY; NEUROTRANSMITTER RELEASE; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL;

AGE FACTORS; ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; BODY WEIGHT; FEMALE; HOMOZYGOTE; LOCOMOTION; MALE; MICE; MICE, MUTANT STRAINS; MOTOR SKILLS; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUTAGENESIS; NEUROPEPTIDES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; SEIZURES; SEX CHARACTERISTICS; SHAW POTASSIUM CHANNELS; STARTLE REACTION;

ANIMALIA;

EID: 0003982199     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.4.1533     Document Type: Article

References (25)

1. Hille, B. (1992) Ionic Channels of Excitable Membranes (Sinauer, Sunderland, MA).
2. Yokoyama, S., Imoto, K., Kawamura, T., Higashida, H., Iwabe, N., Miyata, T. & Numa, S. (1989) FEBS Lett. 259, 37-42.
3. Luneau, C. J., Williams, J. B., Marshall, J., Levitan, E. S., Oliva, C., Smith, J. S., Antanavage, J., Folander, K., Stein, R. B., Swanson, R., Kaczmarek, L. K. & Buhrow, S. A. (1991) Proc. Natl. Acad. Sci. USA 88, 3932-3936.
4. Drewe, J. A., Verma, S., Frech, G. C. & Johu, R. H. (1992) J. Neurosci. 2, 538-548.
5. Perney, T. M., Marshall, J., Martin, K. A., Hockfield, S. & Kaczmarek, L. K. (1992) J. Neurophysiol. 68, 756-7766.
6. Weiser, M., Vega-Saenz de Miera, E., Kentros, C., Moreno, H., Franzen, L., Hillman, D., Baker, H. & Rudy, B. (1994) J. Neurosci. 14, 949-972.
7. Weiser, M., Bueno, E., Sekirnjak, C., Martone, M. E., Baker, H., Hillman, D., Chen, S., Thornhill, W., Ellisman, M. & Rudy, B. (1995) J. Neurosci. 15, 4298-4314.
8. Lenz, S., Perney, T. M., Robbins, Y. Q. E. & Chesselet, M.-F. (1994) Synapse 18, 55-66.
9. Du, J., Zhang, L., Weiser, M., Rudy, B. & McBain, C. J. (1996) J. Neurosci. 16, 506-518.
10. Grissmer, S., Cahalan, M. D. & Chandy, K. G. (1988) J. Immunol. 141, 1137-1142.
11. Grissmer, S., Nguyen, A. N., Aiyar, J., Hanson, D. C., Mather, R. J., Gutman, G. A., Karmilowicz, M. J., Auperin, D. D. & Chandy, K. G. (1994) Mol. Pharmacol. 45, 1227-1234.
12. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. & Struhl, K. (1987) Current Protocols in Molecular Biology (Greene/Wiley, New York).
13. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
14. McClearn, G. E. (1982) in The Mouse in Biomedical Research, eds. Foster, H. L., Small, J. D. & Fox, J. G. (Academic, New York), Vol. 4, pp. 37-49.
15. Gerlai, R. (1996) Trends Neurosci. 19, 177-181.
16. Stühmer, W., Ruppersberg, J. P., Schröter, K. H., Sakmann, B., Stocker, M., Giese, K. P., Perschke, A., Baumann, A. & Pongs, O. (1989) EMBO J. 8, 3235-3244.
17. Frech, G. C., VanDongen, A. M. J., Schuster, G., Brown, A. M. & Joho, R. H. (1989) Nature (London) 340, 642-645.
18. Xu, J., Yu, W., Jan, Y. N., Jan, L. Y. & Li, M. (1995) J. Biol. Chem. 270, 24761-24768.
19. Goldowitz, D. & Koch, J. (1986) Behav. Neural Biol. 46, 216-226.
20. Brew, H. M. & Forsythe, I. D. (1995) J. Neurosci. 15, 8011-8022.
21. Fay, R. R. (1988) Hearing in Vertebrates: A Psychophysics Databook (Hill-Fay Associates, Winnetka, IL).
22. Browne, D. L., Gancher, S. T., Nutt, J. G., Brunt, E. R. P., Smith, E. A., Kramer, P. & Litt, M. (1994) Nat. Genet. 8, 136-140.
23. Curran, M. E., Splawski, I., Timothy, K. W., Vincent, G. M., Green, E. D. & Keating, M. T. (1995) Cell 80, 795-803.
24. Wang, Q., Curran, M. E., Splawski, I., Burn, T. C., Millholland, J. M., VanRaay, T. J., Shen, J., Timothy, K. W., Vincent, G. M., de Jager, T., Schwartz, P. J., Towbin, J. A., Moss, A. J., Atkinson, D. L., Landes, G. M., Connors, T. D. & Keating, M. T. (1996) Nat. Genet. 12, 17-23.
25. Lehmann-Horn, F. & Rüdel, R. (1995) Curr. Opin. Neurol. 8, 402-410.