Progression to type 1 diabetes and autoantibody positivity in relation to HLA-risk genotypes in children participating in the ABIS study

Pediatric Diabetes

Volumn 9, Issue 3 PART 1, 2008, Pages 182-190

  Gullstrand, Camilla ^a   Wahlberg, Jeanette ^a   Ilonen, Jorma ^b,c   Vaarala, Duti ^a,d   Ludvigsson, Johnny ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Autoantibodies; GADA; HLA risk genotype; IA 2A; T1D

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE ANTIBODY; HLA ANTIGEN; HLA DQ ANTIGEN; HLA DQ2 ANTIGEN; HLA DQ5 ANTIGEN; HLA DQ6 ANTIGEN; HLA DQ7 ANTIGEN; HLA DQ8 ANTIGEN; HLA DR ANTIGEN; HLA DR11 ANTIGEN; HLA DR12 ANTIGEN; HLA DR1303 ANTIGEN; HLA DR14 ANTIGEN; HLA DR2 ANTIGEN; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; PANCREAS ISLET CELL ANTIBODY; PROTEIN TYROSINE PHOSPHATASE LIKE ISLET ANTIGEN 2A ANTIBODY;

ALLELE; ANTIBODY DETECTION; ANTIGEN FUNCTION; ARTICLE; AUTOIMMUNITY; CHILD; CONTROLLED STUDY; DISEASE COURSE; ENVIRONMENTAL FACTOR; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PREDICTION; PRIORITY JOURNAL; SWEDEN;

AUTOANTIBODIES; CHILD; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; GENOTYPE; GLUTAMATE DECARBOXYLASE; HLA ANTIGENS; HLA-D ANTIGENS; HUMANS; INCIDENCE; RISK ASSESSMENT; SWEDEN;

EID: 44649127458     PISSN: 1399543X     EISSN: 13995448     Source Type: Journal    
DOI: 10.1111/j.1399-5448.2008.00369.x     Document Type: Article

References (41)

1. Yoon JW, Jun HS. Autoimmune destruction of pancreatic beta cells. Am J Ther 2005: 12: 580-591.
2. Notkins AL, Lernmark A. Autoimmune type 1 diabetes: Resolved and unresolved issues. J Clin Invest 2001: 108: 1247-1252.
3. Ilonen J, Sjoroos M, Knip M et al. Estimation of genetic risk for type 1 diabetes. Am J Med Genet 2002: 115: 30-36.
4. She JX. Susceptibility to type I diabetes: HLA-DQ and DR revisited. Immunol Today 1996: 17: 323-329.
5. Sanjeevi CB, Landin -Olsson M, Kockum I, Dahlquist G, Lernmark A. Effects of the second HLA-DQ haplotype on the association with childhood insulin-dependent diabetes mellitus. Tissue Antigens 1995: 45: 148-152.
6. Onkamo P, Vaananen S, Karvonen M, Tuomilehto J. Worldwide increase in incidence of type I diabetes - the analysis of the data on published incidence trends. Diabetologia 1999: 42: 1395-1403.
7. Pundziute -Lycka A, Dahlquist G, Nystrom L et al. The incidence of type I diabetes has not increased but shifted to a younger age at diagnosis in the 0-34 years group in Sweden 1983-1998. Diabetologia 2002: 45: 783-791.
8. Karvonen M, Pitkaniemi J, Tuomilehto J. The onset age of type 1 diabetes in Finnish children has become younger. The Finnish Childhood Diabetes Registry Group. Diabetes Care 1999: 22: 1066-1070.
9. Green A, Patterson CC. Trends in the incidence of childhood-onset diabetes in Europe 1989-1998. Diabetologia 2001: 44 (Suppl. 3): B3-B8.
10. Hermann R, Knip M, Veijola R et al. Temporal changes in the frequencies of HLA genotypes in patients with type 1 diabetes -indication of an increased environmental pressure? Diabetologia 2003: 46: 420-425.
11. Gillespie KM, Bain SC, Barnett AH et al. The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. Lancet 2004: 364: 1699-1700.
12. Bottazzo GF, Florin -Christensen A, Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 1974: 2: 1279-1283.
13. Palmer JP, Asplin CM, Clemons P et al. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 1983: 222: 1337-1339.
14. Baekkeskov S, Aanstoot HJ, Christgau S et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990: 347: 151-156.
15. Lan MS, Wasserfall C, Maclaren NK, Notkins AL. IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A 1996: 93: 6367-6370.
16. Notkins AL, Lu J, Li Q et al. IA-2 and IA-2 beta are major autoantigens in IDDM and the precursors of the 40 kDa and 37 kDa tryptic fragments. J Autoimmun 1996: 9: 677-682.
17. Bingley PJ, Bonifacio E, Williams AJ, Genovese S, Bottazzo GF, Gale EA. Prediction of IDDM in the general population: Strategies based on combinations of autoantibody markers. Diabetes 1997: 46: 1701-1710.
18. Bingley PJ, Christie MR, Bonifacio E et al. Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 1994: 43: 1304-1310.
19. Lagasse JM, Brantley MS, Leech NJ et al. Successful prospective prediction of type 1 diabetes in school children through multiple defined autoantibodies: An 8-year follow-up of the Washington State Diabetes Prediction Study. Diabetes Care 2002: 25: 505-511.
20. Verge CF, Stenger D, Bonifacio E et al. Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop. Diabetes 1998: 47: 1857-1866.
21. Kulmala P, Rahko J, Savola K et al. Beta-cell autoimmunity, genetic susceptibility, and progression to type 1 diabetes in unaffected schoolchildren. Diabetes Care 2001: 24: 171-173.
22. Hagopian WA, Sanjeevi CB, Kockum I et al. Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest 1995: 95: 1505-1511.
23. Savola K, Bonifacio E, Sabbah E et al. IA-2 antibodies - a sensitive marker of IDDM with clinical onset in childhood and adolescence. Childhood Diabetes in Finland Study Group. Diabetologia 1998: 41: 424-429.
24. Yu L, Rewers M, Gianani R et al. Antiislet autoantibodies usually develop sequentially rather than simultaneously. J Clin Endocrinol Metab 1996: 81: 4264-4267.
25. Knip M. Disease-associated autoimmunity and prevention of insulin-dependent diabetes mellitus. Ann Med 1997: 29: 447-451.
26. Hummel M, Bonifacio E, Schmid S, Walter M, Knopff A, Ziegler AG. Brief communication: Early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents. Ann Intern Med 2004: 140: 882-886.
27. Krischer JP, Cuthbertson DD, Yu L et al. Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes. J Clin Endocrinol Metab 2003: 88: 103-108.
28. Savola K, Laara E, Vahasalo P, Kulmala P, Akerblom HK, Knip M. Dynamic pattern of disease-associated autoantibodies in siblings of children with type 1 diabetes: A population-based study. Diabetes 2001: 50: 2625-2632.
29. Achenbach P, Warncke K, Reiter J et al. Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes 2004: 53: 384-392.
30. Kukko M, Kimpimaki T, Korhonen S et al. Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general population. J Clin Endocrinol Metab 2005: 90: 2712-2717.
31. Kupila A, Muona P, Simell T et al. Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort. Diabetologia 2001: 44: 290-297.
32. Kimpimaki T, Kupila A, Hamalainen AM et al. The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: The Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metab 2001: 86: 4782-4788.
33. Barker JM, Barriga KJ, Yu L et al. Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). J Clin Endocrinol Metab 2004: 89: 3896-3902.
34. Ludvigsson J, Ludvigsson M, Sepa A. Screening for prediabetes in the general child population: Maternal attitude to participation. Pediatr Diabetes 2001: 2: 170-174.
35. Wahlberg J, Fredriksson J, Nikolic E, Vaarala O, Ludvigsson J. Environmental factors related to the induction of beta-cell autoantibodies in 1-yr-old healthy children. Pediatr Diabetes 2005: 6: 199-205.
36. Hermann R, Turpeinen H, Laine AP et al. HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: An analysis of 622 nuclear families. Tissue Antigens 2003: 62: 162-169.
37. Koeleman BP, Lie BA, Undlien DE et al. Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease. Genes Immun 2004: 5: 381-388.
38. Lambert AP, Gillespie KM, Thomson G et al. Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: A population-based study in the United Kingdom. J Clin Endocrinol Metab 2004: 89: 4037-4043.
39. Yu J, Yu L, Bugawan TL et al. Transient antiislet autoantibodies: infrequent occurrence and lack of association with "genetic"risk factors. J Clin Endocrinol Metab 2000: 85: 2421-2428.
40. Vardi P, Ziegler AG, Mathews JH et al. Concentration of insulin autoantibodies at onset of type I diabetes. Inverse log-linear correlation with age. Diabetes Care 1988: 11: 736-739.
41. Bakhtadze E, Borg H, Stenstrom G et al. HLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden. Diabetologia 2006: 49: 1785-1794.