Alpha2-containing GABAA receptors are involved in mediating stimulant effects of cocaine

Pharmacology Biochemistry and Behavior

Volumn 90, Issue 1, 2008, Pages 9-18

  Morris, H V ^a   Dawson, G R ^b   Reynolds, D S ^b   Atack, J R ^b   Rosahl, T W ^b   Stephens, D N ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

2(H101R); alpha 2; Behavioural sensitisation; Benzodiazepine; Cocaine; GABAA receptor; Knockin; Point mutation

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA3; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA5; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA6; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; COCAINE; DIAZEPAM; MIDAZOLAM; RECEPTOR SUBTYPE; TRITIUM;

ADAPTATION; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BEHAVIOR; BRAIN REGION; CHEMOSENSITIZATION; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; HYPERACTIVITY; LOCOMOTION; MALE; MESOLIMBIC DOPAMINERGIC SYSTEM; MOUSE; NERVE CELL PLASTICITY; NERVE PROJECTION; NERVE STIMULATION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RECEPTOR BINDING; WILD TYPE;

ANIMALS; AUTORADIOGRAPHY; AZIDES; BENZODIAZEPINES; BRAIN CHEMISTRY; CENTRAL NERVOUS SYSTEM STIMULANTS; COCAINE; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA MODULATORS; HYPERKINESIS; MICE; MICE, KNOCKOUT; MIDAZOLAM; MOTOR ACTIVITY; PROTEIN SUBUNITS; RECEPTORS, GABA-A;

MUS;

EID: 44649126302     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2008.02.010     Document Type: Article

References (58)

1. Akimoto K., Hamamura T., Kazahaya Y., Akiyama K., and Otsuki S. Enhanced extracellular dopamine level may be the fundamental neuropharmacological basis of cross-behavioral sensitization between methamphetamine and cocaine-an in vivo dialysis study in freely moving rats. Brain Res 507 (1990) 344-346
2. Alheid G.F., and Heimer L. New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: the striatopallidal, amygdaloid, and corticopetal components of substantia innominata. Neuroscience 27 (1988) 1-39
3. Arban R., Maraia G., Brackenborough K., Winyard L., Wilson A., Gerrard P., et al. Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania. Behav Brain Res 158 (2005) 123-132
4. Austin M.C., and Kalivas P.W. The effect of cholinergic stimulation in the nucleus accumbens on locomotor behavior. Brain Res 441 (1988) 209-214
5. Aylmer C.G., Steinberg H., and Webster R.A. Hyperactivity induced by dexamphetamine/chlordiazepoxide mixtures in rats and its attenuation by lithium pretreatment: a role for dopamine?. Psychopharmacology (Berl) 91 (1987) 198-206
6. Benke D., Fakitsas P., Roggenmoser C., Michel C., Rudolph U., and Mohler H. Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits. J Biol Chem 279 (2004) 43654-43660
7. Benson J.A., Low K., Keist R., Mohler H., and Rudolph U. Pharmacology of recombinant gamma-aminobutyric acid A receptors rendered diazepam-insensitive by point-mutated alpha-subunits. FEBS Lett 431 (1998) 400-404
8. Bourdelais A., and Kalivas P.W. Amphetamine lowers extracellular GABA concentration in the ventral pallidum. Brain Res 516 (1990) 132-136
9. Cador M., Bjijou Y., and Stinus L. Evidence of a complete independence of the neurobiological substrates for the induction and expression of behavioral sensitization to amphetamine. Neuroscience 65 (1995) 385-395
10. Cao B.J., and Peng N.A. Magnesium valproate attenuates hyperactivity induced by dexamphetamine-chlordiazepoxide mixture in rodents. Eur J Pharmacol 237 (1993) 177-181
11. Chen Q., Lee T.H., Wetsel W.C., Sun Q.A., Liu Y., Davidson C., et al. Reversal of cocaine sensitization-induced behavioral sensitization normalizes GAD67 and GABAA receptor alpha2 subunit expression, and PKC zeta activity. Biochem Biophys Res Commun 356 (2007) 733-738
12. Corda M.G., Giorgi O., Longoni B., and Biggio G. Ro 15-4513, a partial inverse agonist for benzodiazepine recognition sites, has proconflict and proconvulsant effects in the rat. Eur J Pharmacol 159 (1989) 233-239
13. Crestani F., Martin J.R., Mohler H., and Rudolph U. Resolving differences in GABAA receptor mutant mouse studies. Nat Neurosci 3 (2000) 1059
14. Crestani F., Assandri R., Tauber M., Martin J.R., and Rudolph U. Contribution of the alpha1-GABA(A) receptor subtype to the pharmacological actions of benzodiazepine site inverse agonists. Neuropharmacology 43 (2002) 679-684
15. Cunningham S.T., Finn M., and Kelley A.E. Sensitization of the locomotor response to psychostimulants after repeated opiate exposure: role of the nucleus accumbens. Neuropsychopharmacology 16 (1997) 147-155
16. Dencker D., Dias R., Pedersen M.L., and Husum H. Effect of the new antiepileptic drug retigabine in a rodent model of mania. Epilepsy Behav 12 (2008) 49-53
17. Di Chiara G., and Imperato A. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci U S A 85 (1988) 5274-5278
18. Dias R.S., Sheppard W.F.A., Fradley R.L., Garrett E.M., Stanley J.L., Tye S.J., et al. Evidence to show a significant role for a3-containing GABAA receptors in mediating the anxiolytic effects induced by benzodiazepines. J Neurosci 25 (2005) 10682-10688
19. Dougherty Jr. G.G., and Ellinwood Jr. E.H. Chronic d-amphetamine in nucleus accumbens: lack of tolerance or reverse tolerance of locomotor activity. Life Sci 28 (1981) 2295-2298
20. Ferre S., O'Connor W.T., Snaprud P., Ungerstedt U., and Fuxe K. Antagonistic interaction between adenosine A2A receptors and dopamine D2 receptors in the ventral striopallidal system. Implications for the treatment of schizophrenia. Neuroscience 63 (1994) 765-773
21. Gong W., Justice Jr. J.B., and Neill D. Dissociation of locomotor and conditioned place preference responses following manipulation of GABA-A and AMPA receptors in ventral pallidum. Prog Neuropsychopharmacol Biol Psychiatry 21 (1997) 839-852
22. Heimer L., Zahm D.S., Churchill L., Kalivas P.W., and Wohltmann C. Specificity in the projection patterns of accumbal core and shell in the rat. Neuroscience 41 (1991) 89-125
23. Kalivas P.W., and Duffy P. Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse 5 (1990) 48-58
24. Kalivas P.W., and Stewart J. Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res Brain Res Rev 16 (1991) 223-244
25. Kalivas P.W., Churchill L., and Klitenick M.A. GABA and enkephalin projection from the nucleus accumbens and ventral pallidum to the ventral tegmental area. Neuroscience 57 (1993) 1047-1060
26. Kazahaya Y., Akimoto K., and Otsuki S. Subchronic methamphetamine treatment enhances methamphetamine- or cocaine-induced dopamine efflux in vivo. Biol Psychiatry 25 (1989) 903-912
27. Kelley P.H., and Iversen S.D. Selective 6OHDA-induced destruction of mesolimbic dopamine neurons: abolition of psychostimulant-induced locomotor activity in rats. Eur J Pharmacol 40 (1975) 45-56
28. Ladona M.G., Gonzalez M.L., Rane A., Peter R.M., and de la Torre R. Cocaine metabolism in human fetal and adult liver microsomes is related to cytochrome P450 3A expression. Life Sci 68 (2000) 431-443
29. Lamberty Y., Margineanu D.G., and Klitgaard H. Effect of the new antiepileptic drug levetiracetam in an animal model of mania. Epilepsy Behav 2 (2001) 454-459
30. Le Merrer J., and Stephens D.N. Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake. J Neurosci 26 (2006) 7163-7171
31. Lister R.G., and Nutt D.J. Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants. Br J Pharmacol 93 (1988) 210-214
32. McDaid J., Dallimore J.E., Mackie A.R., Mickiewicz A.L., and Napier T.C. Cross-sensitization to morphine in cocaine-sensitized rats: behavioral assessments correlate with enhanced responding of ventral pallidal neurons to morphine and glutamate, with diminished effects of GABA. J Pharmacol Exp Ther 313 (2005) 1182-1193
33. McKernan R.M., Rosahl T.W., Reynolds D.S., Sur C., Wafford K.A., Atack J.R., et al. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. Nat Neurosci 3 (2000) 587-592
34. Mead A.N., and Stephens D.N. AMPA-receptors are involved in the expression of amphetamine-induced behavioural sensitisation, but not in the expression of amphetamine-induced conditioned activity in mice. Neuropharmacology 37 (1998) 1131-1138
35. Mogenson G.J., and Nielsen M.A. Evidence that an accumbens to subpallidal GABAergic projection contributes to locomotor activity. Brain Res Bull 11 (1983) 309-314
36. Morris H.V., Dawson G.R., Reynolds D.S., Atack J.R., and Stephens D.N. Both alpha2 and alpha3 GABAA receptor subtypes mediate the anxiolytic properties of benzodiazepine site ligands in the conditioned emotional response paradigm. Eur J Neurosci 23 (2006) 2495-2504
37. Morris HV, Dixon CI, Breen G, Desrivieres S, Vallada H, Rosahl TW, et al. Cocaine incentive-learning and addiction are linked to a2-containing GABAA receptors. submitted for publication.
38. Perugini M., and Vezina P. Amphetamine administered to the ventral tegmental area sensitizes rats to the locomotor effects of nucleus accumbens amphetamine. J Pharmacol Exp Ther 270 (1994) 690-696
39. Pirker S., Schwarzer C., Wieselthaler A., Sieghart W., and Sperk G. GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101 (2000) 815-850
40. Pritchett D.B., Sontheimer H., Shivers B.D., Ymer S., Kettenmann H., Schofield P.R., et al. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology. Nature 338 (1989) 582-585
41. Ritz M.C., and George F.R. Cocaine-induced convulsions: pharmacological antagonism at serotonergic, muscarinic and sigma receptors. Psychopharmacology (Berl) 129 (1997) 299-310
42. Rudolph U., Crestani F., Benke D., Brunig I., Benson J.A., Fritschy J.M., et al. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature 401 (1999) 796-800
43. Rushton R., and Steinberg H. Combined effects of chlordiazepoxide and dexamphetamine on activity of rats in an unfamiliar environment. Nature 211 (1966) 1312-1313
44. Sansone M. Influence of benzodiazepine tranquilizers on amphetamine-induced locomotor stimulation in mice. Psychopharmacology (Berl) 71 (1980) 63-65
45. Sansone M., Renzi P., and Vetulani J. Facilitation of stimulatory effect of chlordiazepoxide-amphetamine combination by subacute administration of chlordiazepoxide in mice. Psychopharmacology (Berl) 89 (1986) 52-54
46. Schwarzer C., Berresheim U., Pirker S., Wieselthaler A., Fuchs K., Sieghart W., et al. Distribution of the major gamma-aminobutyric acid(A) receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat. J Comp Neurol 433 (2001) 526-549
47. Sethy V.H., Naik P.Y., and Sheth U.K. Effect of d-amphetamine sulphate in combination with CNS depressants on spontaneous motor activity of mice. Psychopharmacologia 18 (1970) 19-25
48. Shi W.X., and Rayport S. GABA synapses formed in vitro by local axon collaterals of nucleus accumbens neurons. J Neurosci 14 (1994) 4548-4560
49. Stewart J. Conditioned and unconditioned drug effects in relapse to opiate and stimulant drug self-administration. Prog Neuropsychopharmacol Biol Psychiatry 7 (1983) 591-597
50. Stewart J., and Vezina P. Microinjections of Sch-23390 into the ventral tegmental area and substantia nigra pars reticulata attenuate the development of sensitization to the locomotor activating effects of systemic amphetamine. Brain Res 495 (1989) 401-406
51. Vale A.L., and Ratcliffe F. Effect of lithium administration on rat brain 5-hydroxyindole levels in a possible animal model for mania. Psychopharmacology (Berl) 91 (1987) 352-355
52. Vezina P., and Stewart J. Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditioned effects. Brain Res 516 (1990) 99-106
53. Wafford K.A., Macaulay A.J., Fradley R., O'Meara G.F., Reynolds D.S., and Rosahl T.W. Differentiating the role of gamma-aminobutyric acid type A (GABAA) receptor subtypes. Biochem Soc Trans 32 (2004) 553-556
54. Wallace L.J., and Uretsky N.J. Effect of GABAergic and glutamatergic drugs injected into the ventral pallidum on locomotor activity. Adv Exp Med Biol 295 (1991) 307-314
55. Wieland H.A., Luddens H., and Seeburg P.H. A single histidine in GABAA receptors is essential for benzodiazepine agonist binding. J Biol Chem 267 (1992) 1426-1429
56. Wise R.A., and Bozarth M.A. A psychomotor stimulant theory of addiction. Psychol Rev 94 (1987) 469-492
57. Yang C.R., and Mogenson G.J. An electrophysiological study of the neural projections from the hippocampus to the ventral pallidum and the subpallidal areas by way of the nucleus accumbens. Neuroscience 15 (1985) 1015-1024
58. Yang C.R., and Mogenson G.J. Ventral pallidal neuronal responses to dopamine receptor stimulation in the nucleus accumbens. Brain Res 489 (1989) 237-246