Quantitative analysis of the 4977-bp common deletion of mitochondrial DNA in postmortem frontal cortex from patients with bipolar disorder and schizophrenia

Neuroscience Letters

Volumn 439, Issue 2, 2008, Pages 173-177

  Fuke, Satoshi ^a   Kametani, Mizue ^a   Kato, Tadafumi ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Aging; Bipolar disorder; Deletion; Frontal cortex; Mitochondrial DNA; Schizophrenia

Indexed keywords

MITOCHONDRIAL DNA;

ARTICLE; BIPOLAR DISORDER; CADAVER; FRONTAL CORTEX; GENE DELETION; HUMAN; MUTATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SEX DIFFERENCE;

ADOLESCENT; ADULT; AGE FACTORS; AGED; ANALYSIS OF VARIANCE; BIPOLAR DISORDER; DNA, MITOCHONDRIAL; FEMALE; FRONTAL LOBE; HUMANS; MALE; MIDDLE AGED; POSTMORTEM CHANGES; SCHIZOPHRENIA; SEQUENCE DELETION; SEX FACTORS;

EID: 44649100090     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.05.009     Document Type: Article

References (24)

1. Bandelt H.J., Yao Y.G., and Kivisild T. Mitochondrial genes and schizophrenia. Schizophr. Res. 72 (2005) 267-269
2. Beal M.F. Mitochondria take center stage in aging and neurodegeneration. Ann. Neurol. 58 (2005) 495-505
3. Bender A., Krishnan K.J., Morris C.M., Taylor G.A., Reeve A.K., Perry R.H., Jaros E., Hersheson J.S., Betts J., Klopstock T., Taylor R.W., and Turnbull D.M. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat. Genet. 38 (2006) 515-517
4. Ben-Shachar D. Mitochondrial dysfunction in schizophrenia: a possible linkage to dopamine. J. Neurochem. 83 (2002) 1241-1251
5. Cavelier L., Jazin E.E., Eriksson I., Prince J., Båve U., Oreland L., and Gyllensten U. Decreased cytochrome-c oxidase activity and lack of age-related accumulation of mitochondrial DNA deletions in the brains of schizophrenics. Genomics 29 (1995) 217-224
6. Chan D.C. Mitochondria: dynamic organelles in disease, aging, and development. Cell 125 (2006) 1241-1252
7. Chomyn A., and Attardi G. MtDNA mutations in aging and apoptosis. Biochem. Biophys. Res. Commun. 304 (2003) 519-529
8. Corral-Debrinski M., Horton T., Lott M.T., Shoffner J.M., Beal M.F., and Wallace D.C. Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat. Genet. 2 (1992) 324-329
9. Cortopassi G.A., Shibata D., Soong N.W., and Arnheim N. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 7370-7374
10. Dimauro S., and Davidzon G. Mitochondrial DNA and disease. Ann. Med. 37 (2005) 222-232
11. Iwamoto K., Bundo M., and Kato T. Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum. Mol. Genet. 14 (2005) 241-253
12. Iwamoto K., Ueda J., Nakano Y., Bundo M., Ukai W., Hashimoto E., Saito T., and Kato T. Evaluation of whole genome amplification methods using postmortem brain samples. J. Neurosci. Methods 165 (2007) 104-110
13. Kakiuchi C., Ishiwata M., Kametani M., Nelson C., Iwamoto K., and Kato T. Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia. Int. J. Neuropsychopharmacol. 8 (2005) 515-522
14. Kasahara T., Kubota M., Miyauchi T., Noda Y., Mouri A., Nabeshima T., and Kato T. Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Mol. Psychiatry 11 (2006) 577-593 523
15. Kato T. Mitochondrial dysfunction as the molecular basis of bipolar disorder: therapeutic implications. CNS Drugs 21 (2007) 1-11
16. Kato T., Stine O.C., McMahon F.J., and Crowe R.R. Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder. Biol. Psychiatry 42 (1997) 871-875
17. Konradi C., Eaton M., MacDonald M.L., Walsh J., Benes F.M., and Heckers S. Molecular evidence for mitochondrial dysfunction in bipolar disorder. Arch. Gen. Psychiatry 61 (2004) 300-308
18. Kraytsberg Y., Kudryavtseva E., McKee A.C., Geula C., Kowall N.W., and Khrapko K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat. Genet. 38 (2006) 518-520
19. Kubota M., Kasahara T., Nakamura T., Ishiwata M., Miyauchi T., and Kato T. Abnormal Ca2+ dynamics in transgenic mice with neuron-specific mitochondrial DNA defects. J. Neurosci. 26 (2006) 12314-12324
20. Marchbanks R.M., Ryan M., Day I.N., Owen M., McGuffin P., and Whatley S.A. A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress. Schizophr. Res. 65 (2003) 33-38
21. Sabunciyan S., Kirches E., Krause G., Bogerts B., Mawrin C., Llenos I.C., and Weis S. Quantification of total mitochondrial DNA and mitochondrial common deletion in the frontal cortex of patients with schizophrenia and bipolar disorder. J. Neural. Transm. 114 (2007) 665-674
22. Soong N.W., Hinton D.R., Cortopassi G., and Arnheim N. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat. Genet. 2 (1992) 318-323
23. Stork C., and Renshaw P.F. Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research. Mol. Psychiatry 10 (2005) 900-919
24. Uranova N., Orlovskaya D., Vikhreva O., Zimina I., Kolomeets N., Vostrikov V., and Rachmanova V. Electron microscopy of oligodendroglia in severe mental illness. Brain Res. Bull. 55 (2001) 597-610