ENSAM: Europium Nanoparticles for Signal enhancement of Antibody Microarrays on silicon

Journal of Proteome Research

Volumn 7, Issue 3, 2008, Pages 1308-1314

  Järås, Kerstin ^a   Tajudin, Asilah Ahmad ^a   Ressine, Anton ^a   Soukka, Tero ^b   Marko Varga, György ^a   Bjartell, Anders ^a   Malm, Johan ^a   Laurell, Thomas ^a   Lilja, Hans ^a,c  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF TURKU   (Finland)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Antibody microarrays; Europium; Lanthanides; Nanobeads; Nanoparticles; Porous silicon; Prostate cancer; Prostate specific antigen; Protein chip; Time resolved fluorescence

Indexed keywords

1,3 DIKETONE; CHELATING AGENT; EUROPIUM; NANOPARTICLE; POLYSTYRENE; PROSTATE SPECIFIC ANTIGEN; STREPTAVIDIN; ANTIBODY; SILICON;

ANTIBODY COMBINING SITE; ANTIBODY DETECTION; ARTICLE; BIOTINYLATION; CHELATION; CHROMATOPHORE; DNA MICROARRAY; EUROPIUM NANOPARTICLES FOR SIGNAL ENHANCEMENT OF ANTIBODY MICROARRAYS; FLUORESCENCE ANALYSIS; FLUOROPHORE; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; MATERIAL COATING; NANOARRAY; NANOTECHNOLOGY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; STREPTAVIDIN EUROPIUM CHELATE ASSAY; SURFACE PROPERTY; TITRIMETRY; CHEMISTRY; SENSITIVITY AND SPECIFICITY; SPECTROFLUOROMETRY;

ANTIBODIES; EUROPIUM; NANOPARTICLES; SENSITIVITY AND SPECIFICITY; SILICON; SPECTROMETRY, FLUORESCENCE;

EID: 44449165077     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr700591j     Document Type: Article

References (49)

1. Schweitzer, B.; Wiltshire, S.; Lambert, J.; O'Malley, S.; Kukanskis, K.; Zhu, Z.; Kingsmore, S. F.; Lizardi, P. M.; Ward, D. C. Inaugural article: immunoassays with rolling circle DNA amplification: a versatile platform for ultrasensitive antigen detection. Proc. Natl. Acad. Sci. U.S.A. 2000, 97 (18), 10113-10119.
2. Zhou, H.; Bouwman, K.; Schotanus, M.; Verweij, C.; Marrero, J. A.; Dillon, D.; Costa, J.; Lizardi, P.; Haab, B. B. Two-color, rolling-circle amplification on antibody microarrays for sensitive, multiplexed serum-protein measurements. GenomeBiology 2004, 5 (4), R28.
3. Lizardi, P. M.; Huang, X.; Zhu, Z.; Bray-Ward, P.; Thomas, D. C.; Ward, D. C. Mutation detection and single-molecule counting using isothermal rolling-circle amplification. Nat. Genet. 1998, 19 (3), 225-32.
4. Jarvius, M.; Paulsson, J.; Weibrecht, I.; Leuchowius, K. J.; Ander-sson, A. C.; Wahlby, C.; Gullberg, M.; Boding, J.; Sjoblom, T.; Markova, B.; Ostman, A.; Landegren, U.; Soderberg, O. In situ detection of phosphorylated PDGF receptor beta using a generalized proximity ligation method. Mol. Cell. Proteomics 2007, 6, 1500-1509.
5. Wiltshire, S.; O'Malley, S.; Lambert, J.; Kukanskis, K.; Edgar, D.; Kingsmore, S. F.; Schweitzer, B. Detection of multiple allergen-specific IgEs on microarrays by immunoassay with rolling circle amplification. Clin. Chem. 2000, 46 (12), 1990-1993.
6. Rapkiewicz, A.; Espina, V.; Zujewski, J. A.; Lebowitz, P. F.; Filie, A.; Wulfkuhle, J.; Camphausen, K.; Petricoin, E. F., 3; Liotta, L. A.; Abati, A. The needle in the haystack: application of breast fine-needle aspirate samples to quantitative protein microarray technology. Cancer 2007, 111 (3), 173-184.
7. Calvert, V. S.; Collantes, R.; Elariny, H.; Afendy, A.; Baranova, A.; Mendoza, M.; Goodman, Z.; Liotta, L. A.; Petricoin, E. F.; Younossi, Z. M. A systems biology approach to the pathogenesis of obesity-related nonalcoholic fatty liver disease using reverse phase protein microarrays for multiplexed cell signaling analysis. Hepatology 2007, 46 (1), 166-72.
8. Nishizuka, S.; Charboneau, L.; Young, L.; Major, S.; Reinhold, W. C.; Waltham, M.; Kouros-Mehr, H.; Bussey, K. J.; Lee, J. K.; Espina, V.; Munson, P. J.; Petricoin, E., 3; Liotta, L. A.; Weinstein, J. N. Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays. Proc. Natl. Acad. Sci. U.S.A. 2003, 100 (24), 14229-14234.
9. Ingvarsson, J.; Larsson, A.; Sjoholm, A. G.; Truedsson, L.; lansson, B.; Borrebaeck, C. A.; Wingren, C. Design of recombinant antibody microarrays for serum protein profiling: targeting of complement proteins. J. Proteome. Res. 2007, 6, 3527-3536.
10. Ekins, R. P.; Chu, F. W. Multianalyte microspot immunoassay- microanalytical "compact disk" of the future. Clin. Chem. 1991, 37 (11), 1955-1967.
11. Joos, T. O.; Stoll, D.; Templin, M. F. Miniaturised multiplexed immunoassays. Curr. Opin. Chem. Biol. 2002, 6 (1), 76-80.
12. Zhu, H.; Bilgin, M.; Bangham, R.; Hall, D.; Casamayor, A.; Bertone, P.; Lan, N.; Jansen, R.; Bidlingmaier, S.; Houfek, T.; Mitchell, T.; Miller, P.; Dean, R. A.; Gerstein, M.; Snyder, M. Global analysis of protein activities using proteome chips. Science 2001, 293 (5537), 2101-2105.
13. Templin, M. F.; Stoll, D.; Schrenk, M.; Traub, P. C.; Vohringer, C. F.; Joos, T. O. Protein microarray technology. Trends Biotechnol. 2002, 20 (4), 160-166.
14. MacBeath, G.; Schreiber, S. L. Printing proteins as microarrays for high-throughput function determination. Science 2000, 289 (5485), 1760-1763.
15. Miller, J. C.; Zhou, H.; Kwekel, J.; Cavallo, R.; Burke, J.; Buder, E. B.; Teh, B. S.; Haab, B. B. Antibody microarray profiling of human prostate cancer sera: antibody screening and identification of potential biomarkers. Proteomics 2003, 3 (1), 56-63.
16. Zhu, H.; Hu, S.; Jona, G.; Zhu, X.; Kreiswirth, N.; Willey, B. M.; Mazzulli, T.; Liu, G.; Song, Q.; Chen, P.; Cameron, M.; Tyler, A.; Wang, J.; Wen, J.; Chen, W.; Compton, S.; Snyder, M. Severe acute respiratory syndrome diagnostics using a coronavirus protein microarray. Proc. Natl. Acad. Set U.S.A. 2006, 103 (11), 4011-4016.
17. Ho, S. W.; Jona, G.; Chen, C. T.; Johnston, M.; Snyder, M. Linking DNA-binding proteins to their recognition sequences by using protein microarrays. Proc. Natl. Acad. Sci. U.S.A. 2006, 103 (26), 9940-9945.
18. Lilja, H.; Ulmert, D.; Bjork, T.; Becker, C.; Serio, A. M.; Nilsson, J. A.; Abrahamsson, P. A.; Vickers, A. J.; Berglund, G. Long-term prediction of prostate cancer up to 25 years before diagnosis of prostate cancer using prostate kallikreins measured at age 44 to 50 years. J. Clin. Oncol. 2007, 25 (4), 431-436.
19. Shaw, J. L.; Diamandis, E. P. Distribution of 15 human kallikreins in tissues and biological fluids. Clin. Chem. 2007, 53 (8), 1423-1432.
20. Jaras, K.; Ressine, A.; Nilsson, E.; Malm, J.; Marko-Varga, G.; Lilja, H.; Laurell, T. Reverse-phase versus sandwich antibody microarray, technical comparison from a clinical perspective. Anal. Chem. 2007, 79 (15), 5817-5825.
21. Ressine, A.; Finnskog, D.; Malm, J.; Becker, C; Lilja, H.; Marko-Varga, G.; Laurell, T. Macro/nano-structured silicon as solid support for antibody arrays. Surface design, reproducibility and assay characteristics enabling discovery of kallikrein gene products for prostate disease diagnostics. Nano Biotechnology 2005, 1 (1), 93-104.
22. Wieder, I. Background rejection in fluorescent immunoassay. In Immunofluorescence and Related Staining Techniques; Knapp, W., Holubar, K. Wick, G., Eds.; Elsevier: Amsterdam, 1978; pp 67-80.
23. Siitari, H.; Hemmila, I.; Soini, E.; Lovgren, T.; Koistinen, V. Detection of hepatitis B surface antigen using time-resolved fluoroimmunoassay. Nature 1983, 301 (5897), 258-260.
24. Ekins, R. P.; Dakubu, S. The development of high-sensitivity pulsed-light, time-resolved fluoroimmunoassays. Pure Appl. Chem. 1985, 57 (3), 473-482.
25. Soini, E.; Lovgren, T. Time-resolved fluorescence of lanthanide probes and applications in biotechnology. CRC Crit. Rev. Anal. Chem. 1987, 18 (2), 105-154.
26. Dickson, E. F.; Pollak, A.; Diamandis, E. P. Ultrasensitive bioana-lytical assays using time-resolved fluorescence detection. Pharmacol. Ther. 1995, 66 (2), 207-235.
27. Lovgren, T.; Heinonen, P.; Lehtinen, P.; Hakala, H.; Heinola, J.; Harju, R.; Takalo, H.; Mukkala, V. M.; Schmid, R.; Lonnberg, H.; Pettersson, K.; Iitia, A. Sensitive bioaffinity assays with individual microparticles and time-resolved fluorometry. Clin. Chem. 1997, 43 (10), 1937-1943.
28. Soukka, T.; Antonen, K.; Harma, H.; Pelkkikangas, A. M.; Huhtinen, P.; Lovgren, T. Highly sensitive immunoassay of free prostate-specific antigen in serum using europium(III) nanoparticle label technology. Clin. Chim. Acta 2003, 328 (1-2), 45-58.
29. Soukka, T.; Paukkunen, J.; Harma, H.; Lonnberg, S.; Lindroos, H.; Lovgren, T. Supersensitive time-resolved immunofluorometric assay of free prostate-specific antigen with nanoparticle label technology. Clin. Chem. 2001, 47 (7), 1269-1278.
30. Harma, H.; Soukka, T.; Lovgren, T. Europium nanoparticles and time-resolved fluorescence for ultrasensitive detection of prostate-specific antigen. Clin. Chem. 2001, 47 (3), 561-568.
31. Vaisanen, V.; Harma, H.; Lilja, H.; Bjartell, A. Time-resolved fluorescence imaging for quantitative histochemistry using lan-thanide chelates in nanoparticles and conjugated to monoclonal antibodies. Luminescence 2000, 15 (6), 389-397.
32. Valanne, A.; Huopalahti, S.; Soukka, T.; Vainionpaa, R.; Lovgren, T.; Harma, H. A sensitive adenovirus immunoassay as a model for using nanoparticle label technology in virus diagnostics. J. Clin. Virol. 2005, 33 (3), 217-223.
33. Valanne, A.; Huopalahti, S.; Vainionpaa, R.; Lovgren, T.; Harma, H. Rapid and sensitive HBsAg immunoassay based on fluorescent nanoparticle labels and time-resolved detection. J. Virol. Methods 2005, 129 (1), 83-90.
34. Jaakohuhta, S.; Harma, H.; Tuomola, M.; Lovgren, T. Sensitive Listeria spp. immunoassay based on europium(III) nanoparticulate labels using time-resolved fluorescence. Int. J. Food Microbiol. 2007, 114 (3), 288-294.
35. Dosev, D.; Nichkova, M.; Liu, M.; Guo, B.; Liu, G. Y.; Hammock, B. D.; Kennedy, I. M. Application of luminescent Eu;Gd203 nanoparticles to the visualization of protein micropatterns. J. Biomed. Opt. 2005, 10 (6), 064006.
36. Nichkova, M.; Dosev, D.; Gee, S. J.; Hammock, B. D.; Kennedy, I. M. Microarray immunoassay for phenoxybenzoic acid using polymer encapsulated Eu:Gd203 nanoparticles as fluorescent labels. Anal. Chem. 2005, 77 (21), 6864-6873.
37. Nichkova, M.; Dosev, D.; Perron, R.; Gee, S. J.; Hammock, B. D.; Kennedy, I. M. Eu3+-doped Gd203 nanoparticles as reporters for optical detection and visualization of antibodies patterned by microcontact printing. Anal. Bioanal. Chem. 2006, 384 (3), 631-637.
38. Ressine, A.; Ekstrom, S.; Marko-Varga, G.; Laurell, T. Macro-/ nanoporous silicon as a support for high-performance protein microarrays. Anal. Chem. 2003, 75 (24), 6968-6974.
39. Steinhauer, C.; Ressine, A.; Marko-Varga, G.; Laurell, T.; Borrebaeck, C. A.; Wingren, C. Biocompatibility of surfaces for antibody microarrays: design of macroporous silicon substrates. Anal. Biochem. 2005, 341 (2), 204-213.
40. Finnskog, D.; Ressine, A.; Laurell, T.; Marko-Varga, G. Integrated protein microchip assay with dual fluorescent- and MALDI readout. J. Proteome Res. 2004, 3 (5), 988-994.
41. Lilja, H.; Christensson, A.; Dahlen, U.; Matikainen, M. T.; Nilsson, O.; Pettersson, K.; Lovgren, T. Prostate-specific antigen in serum occurs predominantly in complex with alpha 1-antichymotrypsin. Clin. Chem. 1991, 37 (9), 1618-1625.
42. Petterson, K.; Vehnianen, M.; Viloma, S.; Makinen, M. L.; Manstala, P.; Lovgren, T. Comparison of recombinant fab fragment to Mab on immunoassay of human alpha-fetoprotein. Clin. Chem. 1995, 41 (6), S81-S81.
43. Lovgren, J.; Rajakoski, K.; Karp, M.; Lundwall, A.; Lilja, H. Activation of the zymogen form of prostate-specific antigen by human glandular kallikrein 2. Biochem. Biophys. Res. Commun. 1997, 238 (2), 549-555.
44. Kokko, T.; Kokko, L.; Lovgren, T.; Soukka, T. Homogeneous noncompetitive immunoassay for 17beta-estradiol based on fluorescence resonance energy transfer. Anal. Chem. 2007, 79 (15), 5935-5940.
45. von Lode, P.; Rosenberg, J.; Pettersson, K.; Takalo, H. A europium chelate for quantitative point-of-care immunoassays using direct surface measurement. Anal. Chem. 2003, 75 (13), 3193-3201.
46. Laurell, T.; Wallman, L.; Nilsson, J. Design and development of a silicon microfabricated flow-through dispenser for on-line picolitre sample handling. J. Micromech. Microeng. 1999, 9 (4), 369-376.
47. Bardyshev, N. I.; Mokrushin, A. D.; Puryaeva, T. P.; Serebryakova, N. V.; Starkov, V. V. Nanopores in macroporous silicon. Inorg. Mater. 2004, 40 (11), 1127-1132.
48. Steuber, T.; Vickers, A. J.; Haese, A.; Becker, G; Pettersson, K.; Chun, F. K.; Kattan, M. W.; Eastham, J. A.; Scardino, P. T.; Huland, H.; Lilja, H. Risk assessment for biochemical recurrence prior to radical prostatectomy: significant enhancement contributed by human glandular kallikrein 2 (hK2) and free prostate specific antigen (PSA) in men with moderate PSA-elevation in serum. Int. J. Cancer 2006, 118 (5), 1234-1240.
49. Ressine, A.; Marko-Varga, G.; Laurell, T. Porous silicon protein microarray technology and ultra-/superhydrophobic states for improved bioanalytical readout. Biotechnol. Annu. Rev. 2007, 13, 149-200.