-
1
-
-
0023748414
-
Genetic alterations during colorectal-tumor development
-
Vogelstein B, Fearon ER, Hamilton SR et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988; 319: 525-32.
-
(1988)
N Engl J Med
, vol.319
, pp. 525-532
-
-
Vogelstein, B.1
Fearon, E.R.2
Hamilton, S.R.3
-
2
-
-
0037047057
-
Mutations in APC, Kirsten-ras, and p53-alternative genetic pathways to colorectal cancer
-
Smith G, Carey FA, Beattie J et al. Mutations in APC, Kirsten-ras, and p53-alternative genetic pathways to colorectal cancer. Proc Natl Acad Sci USA 2002; 99: 9433-8.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 9433-9438
-
-
Smith, G.1
Carey, F.A.2
Beattie, J.3
-
3
-
-
0032730774
-
Genetic susceptibility to non-polyposis colorectal cancer
-
Lynch HT, de la Chapelle A. Genetic susceptibility to non-polyposis colorectal cancer. J Med Genet 1999; 36: 801 -18.
-
(1999)
J Med Genet
, vol.36
, pp. 801
-
-
Lynch, H.T.1
de la Chapelle, A.2
-
4
-
-
0034785348
-
TGF-β signaling in tumor suppression and cancer progression
-
Derynck R, Akhurst RJ, Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat Genet 2001; 29: 117-29.
-
(2001)
Nat Genet
, vol.29
, pp. 117-129
-
-
Derynck, R.1
Akhurst, R.J.2
Balmain, A.3
-
5
-
-
0036175062
-
Emerging pathways in colorectal-cancer development
-
Haydon AM, Jass JR. Emerging pathways in colorectal-cancer development. Lancet Oncol 2002; 3: 83-8.
-
(2002)
Lancet Oncol
, vol.3
, pp. 83-88
-
-
Haydon, A.M.1
Jass, J.R.2
-
6
-
-
0031893470
-
Mutation of the transforming growth factor-β type II receptor gene in right-sided colorectal cancer: Relationship to clinicopathological features and genetic alterations
-
Iacopetta BJ, Welch J, Soong R, House AK, Zhou XP, Hamelin R. Mutation of the transforming growth factor-β type II receptor gene in right-sided colorectal cancer: Relationship to clinicopathological features and genetic alterations. J Pathol 1998; 184: 390-5.
-
(1998)
J Pathol
, vol.184
, pp. 390-395
-
-
Iacopetta, B.J.1
Welch, J.2
Soong, R.3
House, A.K.4
Zhou, X.P.5
Hamelin, R.6
-
7
-
-
0035912144
-
Molecular predictors of survival after adjuvant chemotherapy for colon cancer
-
Watanabe T, Wu TT, Catalano PJ et al. Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med 2001; 344: 1196-206.
-
(2001)
N Engl J Med
, vol.344
, pp. 1196-1206
-
-
Watanabe, T.1
Wu, T.T.2
Catalano, P.J.3
-
8
-
-
0033565626
-
Transforming growth factor β1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis
-
Engle SJ, Hoying JB, Boivin GP, Ormsby I, Gartside PS, Doetschman T. Transforming growth factor β1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res 1999; 59: 3379-86.
-
(1999)
Cancer Res
, vol.59
, pp. 3379-3386
-
-
Engle, S.J.1
Hoying, J.B.2
Boivin, G.P.3
Ormsby, I.4
Gartside, P.S.5
Doetschman, T.6
-
9
-
-
1642428961
-
-
American Joint Committee on Cancer. (ed. FL Greene et al.) Springer: New York
-
American Joint Committee on Cancer. Cancer Staging Handbook. (ed. FL Greene et al.) 2002; Springer: New York.
-
(2002)
Cancer Staging Handbook.
-
-
-
10
-
-
27744591969
-
Genetic and pathologic changes associated with lymphovascular invasion of colorectal adenocarcinoma
-
Kim JC, Roh SA, Lee KH, Namgung H, Kim JR, Kim JS. Genetic and pathologic changes associated with lymphovascular invasion of colorectal adenocarcinoma. Clin Exp Metastasis 2005; 22: 421-8.
-
(2005)
Clin Exp Metastasis
, vol.22
, pp. 421-428
-
-
Kim, J.C.1
Roh, S.A.2
Lee, K.H.3
Namgung, H.4
Kim, J.R.5
Kim, J.S.6
-
11
-
-
29544435953
-
Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study
-
Lüchtenborg M, Weijenberg MP, Wark PA et al. Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study. BMC Cancer 2005; 5: 160.
-
(2005)
BMC Cancer
, vol.5
, pp. 160
-
-
Lüchtenborg, M.1
Weijenberg, M.P.2
Wark, P.A.3
-
12
-
-
33847733537
-
MYH, OGG1, MTH1, and APC alterations involved in the colorectal tumorigenesis of Korean patients with multiple adenomas
-
Kim JC, Ka IH, Lee YM et al. MYH, OGG1, MTH1, and APC alterations involved in the colorectal tumorigenesis of Korean patients with multiple adenomas. Virchows Arch 2007; 450: 311-19.
-
(2007)
Virchows Arch
, vol.450
, pp. 311-319
-
-
Kim, J.C.1
Ka, I.H.2
Lee, Y.M.3
-
13
-
-
16544363110
-
Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation
-
Nagasaka T, Sasamoto H, Notohara K et al. Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation. J Clin Oncol 2004; 22: 4584-94.
-
(2004)
J Clin Oncol
, vol.22
, pp. 4584-4594
-
-
Nagasaka, T.1
Sasamoto, H.2
Notohara, K.3
-
14
-
-
19944432221
-
DHPLC is superior to SSCP in screening p53 mutations in esophageal cancer tissues
-
Yamanoshita O, Kubota T, Hou J et al. DHPLC is superior to SSCP in screening p53 mutations in esophageal cancer tissues. Int J Cancer 2005; 114: 74-9.
-
(2005)
Int J Cancer
, vol.114
, pp. 74-79
-
-
Yamanoshita, O.1
Kubota, T.2
Hou, J.3
-
15
-
-
14644442314
-
Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability
-
Thorstensen L, Lind GE, Løvig T et al. Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability. Neoplasia 2005; 7: 99-108.
-
(2005)
Neoplasia
, vol.7
, pp. 99-108
-
-
Thorstensen, L.1
Lind, G.E.2
Løvig, T.3
-
16
-
-
0038141208
-
Genetic and epigenetic changes in the APC gene in sporadic colorectal carcinoma with synchronous adenoma
-
Kim JC, Koo KH, Roh SA et al. Genetic and epigenetic changes in the APC gene in sporadic colorectal carcinoma with synchronous adenoma. Int J Colorectal Dis 2003; 18: 203-9.
-
(2003)
Int J Colorectal Dis
, vol.18
, pp. 203-209
-
-
Kim, J.C.1
Koo, K.H.2
Roh, S.A.3
-
17
-
-
0029869360
-
Evidence of reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas
-
Watson AJ, Merritt AJ, Jones LS et al. Evidence of reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas. Br J Cancer 1996; 73: 889-95.
-
(1996)
Br J Cancer
, vol.73
, pp. 889-895
-
-
Watson, A.J.1
Merritt, A.J.2
Jones, L.S.3
-
18
-
-
0030300115
-
MADR2 is a substrate of the TGF β receptor and its phosphorylation is required for nuclear accumulation and signaling
-
Macias-Silva M, Abdollah S, Hoodless P, Pirone R, Attisano L, Wrana JL. MADR2 is a substrate of the TGF β receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 1996; 87: 1215-24.
-
(1996)
Cell
, vol.87
, pp. 1215-1224
-
-
Macias-Silva, M.1
Abdollah, S.2
Hoodless, P.3
Pirone, R.4
Attisano, L.5
Wrana, J.L.6
-
21
-
-
33947121581
-
TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer
-
Ogino S, Kawasaki T, Ogawa A, Kirkner GJ, Loda M, Fuchs CS. TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. Hum Pathol 2007; 38: 614-20.
-
(2007)
Hum Pathol
, vol.38
, pp. 614-620
-
-
Ogino, S.1
Kawasaki, T.2
Ogawa, A.3
Kirkner, G.J.4
Loda, M.5
Fuchs, C.S.6
-
22
-
-
33744506902
-
Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: Proposal for new molecular profile of colorectal carcinomas
-
Sugai T, Habano W, Jiao YF et al. Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: Proposal for new molecular profile of colorectal carcinomas. J Mol Diagn 2006; 8: 193-201.
-
(2006)
J Mol Diagn
, vol.8
, pp. 193-201
-
-
Sugai, T.1
Habano, W.2
Jiao, Y.F.3
-
23
-
-
0031443664
-
Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors
-
Breivik J, Lothe RA, Meling GI, Rognum TO, Børresen-Dale AL, Gaudernack G. Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors. Int J Cancer 1997; 74: 664-9.
-
(1997)
Int J Cancer
, vol.74
, pp. 664-669
-
-
Breivik, J.1
Lothe, R.A.2
Meling, G.I.3
Rognum, T.O.4
Børresen-Dale, A.L.5
Gaudernack, G.6
-
24
-
-
4644297525
-
Characterization of mutator phenotype in familial colorectal cancer patients not fulfilling Amsterdam criteria
-
Kim JC, Lee KH, Ka IH et al. Characterization of mutator phenotype in familial colorectal cancer patients not fulfilling Amsterdam criteria. Clin Cancer Res 2004; 10: 6159-68.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6159-6168
-
-
Kim, J.C.1
Lee, K.H.2
Ka, I.H.3
-
25
-
-
0036006173
-
O6-alkylguanine-DNA alkyltransferase: Role in carcinogenesis and chemotherapy
-
Margison GP, Santibanez-Koref MF. O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy. Bioessays 2002; 24: 255-66.
-
(2002)
Bioessays
, vol.24
, pp. 255-266
-
-
Margison, G.P.1
Santibanez-Koref, M.F.2
-
26
-
-
33644908248
-
Mutational targets in colorectal cancer cells with microsatellite instability
-
Bertholon J, Wang Q, Galmarini CM, Puisieux A. Mutational targets in colorectal cancer cells with microsatellite instability. Fam Cancer 2006; 5: 29-34.
-
(2006)
Fam Cancer
, vol.5
, pp. 29-34
-
-
Bertholon, J.1
Wang, Q.2
Galmarini, C.M.3
Puisieux, A.4
-
27
-
-
14944362453
-
Comprehensive characteriz-ation of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations
-
Abdel-Rahman WM, Ollikainen M, Kariola R et al. Comprehensive characteriz-ation of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations. Oncogene 2005; 24: 1542-51.
-
(2005)
Oncogene
, vol.24
, pp. 1542-1551
-
-
Abdel-Rahman, W.M.1
Ollikainen, M.2
Kariola, R.3
-
28
-
-
0034908622
-
Genomic structure, chromosome mapping and expression analysis of the human AXIN2 gene
-
Dong X, Seelan RS, Qian C, Mai M, Liu W. Genomic structure, chromosome mapping and expression analysis of the human AXIN2 gene. Cytogenet Cell Genet 2001; 93: 26-8.
-
(2001)
Cytogenet Cell Genet
, vol.93
, pp. 26-28
-
-
Dong, X.1
Seelan, R.S.2
Qian, C.3
Mai, M.4
Liu, W.5
-
29
-
-
1542377485
-
Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers
-
Jung B, Doctolero RT, Tajima A et al. Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. Gastroenterology 2004; 126: 654-9.
-
(2004)
Gastroenterology
, vol.126
, pp. 654-659
-
-
Jung, B.1
Doctolero, R.T.2
Tajima, A.3
-
30
-
-
9144271690
-
Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation
-
Domingo E, Espín E, Armengol M et al. Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation. Genes Chromosomes Cancer 2004; 39: 138-42.
-
(2004)
Genes Chromosomes Cancer
, vol.39
, pp. 138-142
-
-
Domingo, E.1
Espín, E.2
Armengol, M.3
-
31
-
-
33947546541
-
Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study
-
Kim GP, Colangelo LH, Wieand HS et al. Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study. J Clin Oncol 2007; 25: 767-72.
-
(2007)
J Clin Oncol
, vol.25
, pp. 767-772
-
-
Kim, G.P.1
Colangelo, L.H.2
Wieand, H.S.3
-
33
-
-
30444446633
-
Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations
-
Grady WM, Willis JE, Trobridge P et al. Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations. Int J Cancer 2006; 118: 600-8.
-
(2006)
Int J Cancer
, vol.118
, pp. 600-608
-
-
Grady, W.M.1
Willis, J.E.2
Trobridge, P.3
-
34
-
-
2942668475
-
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
-
Sansom OJ, Reed KR, Hayes AJ et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev 2004; 18: 1385-90.
-
(2004)
Genes Dev
, vol.18
, pp. 1385-1390
-
-
Sansom, O.J.1
Reed, K.R.2
Hayes, A.J.3
-
35
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417: 949-54.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
36
-
-
37349131738
-
BRAF mutation in papillary thyroid cancer: Pathogenic role, molecular bases, and clinical implications
-
Xing M. BRAF mutation in papillary thyroid cancer: Pathogenic role, molecular bases, and clinical implications. Endocr Rev 2007; 28: 742-62.
-
(2007)
Endocr Rev
, vol.28
, pp. 742-762
-
-
Xing, M.1
-
37
-
-
38149082706
-
Loss of Smad4 protein expression and 18qLOH as molecular markers indicating lymph node metastasis in colorectal cancera study matched for tumor depth and pathology
-
Tanaka T, Watanabe T, Kazama Y et al. Loss of Smad4 protein expression and 18qLOH as molecular markers indicating lymph node metastasis in colorectal cancera study matched for tumor depth and pathology. J Surg Oncol 2008; 97: 69-73.
-
(2008)
J Surg Oncol
, vol.97
, pp. 69-73
-
-
Tanaka, T.1
Watanabe, T.2
Kazama, Y.3
-
38
-
-
33750565444
-
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation
-
Muñoz NM, Upton M, Rojas A et al. Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res 2006; 66: 9837-44.
-
(2006)
Cancer Res
, vol.66
, pp. 9837-9844
-
-
Muñoz, N.M.1
Upton, M.2
Rojas, A.3
-
39
-
-
33847024023
-
Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human
-
Alberici P, de Pater E, Cardoso J et al. Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human. Am J Pathol 2007; 170: 377-87.
-
(2007)
Am J Pathol
, vol.170
, pp. 377-387
-
-
Alberici, P.1
de Pater, E.2
Cardoso, J.3
-
40
-
-
0033168064
-
Apoptosis induced by overexpression of hMSH2 or hMLH1
-
Zhang H, Richards B, Wilson T et al. Apoptosis induced by overexpression of hMSH2 or hMLH1. Cancer Res 1999; 59: 3021-7.
-
(1999)
Cancer Res
, vol.59
, pp. 3021-3027
-
-
Zhang, H.1
Richards, B.2
Wilson, T.3
-
41
-
-
17844368327
-
The MAPK signalling pathways and colorectal cancer
-
Fang JY, Richardson BC. The MAPK signalling pathways and colorectal cancer. Lancet Oncol 2005; 6: 322-7.
-
(2005)
Lancet Oncol
, vol.6
, pp. 322-327
-
-
Fang, J.Y.1
Richardson, B.C.2
-
42
-
-
38049029612
-
The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer
-
Kodach LL, Bleuming SA, Musler AR et al. The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer. Cancer 2008; 112: 300-6.
-
(2008)
Cancer
, vol.112
, pp. 300-306
-
-
Kodach, L.L.1
Bleuming, S.A.2
Musler, A.R.3
-
43
-
-
0035870276
-
Down-regulation of β-catenin TCF signaling is linked to colonic epithelial cell differentiation
-
Mariadason JM, Bordonaro M, Aslam F et al. Down-regulation of β-catenin TCF signaling is linked to colonic epithelial cell differentiation. Cancer Res 2001; 61: 3465-71.
-
(2001)
Cancer Res
, vol.61
, pp. 3465-3471
-
-
Mariadason, J.M.1
Bordonaro, M.2
Aslam, F.3
|