Evidence for reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas

British Journal of Cancer

Volumn 73, Issue 8, 1996, Pages 889-895

  Watson, A J M ^a   Merritt, A J ^a,b   Jones, L S ^c   Askew, J N ^a   Anderson, E ^c   Becciolini, A ^d   Balzi, M ^d   Potten, C S ^b   Hickman, J A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c CHRISTIE HOSPITAL   (United Kingdom)

^d UNIVERSITY OF FLORENCE   (Italy)

Author keywords

bcl 2; Colonic adenomas; Colonic carcinomas; Colonic crypts; Immunohistochemistry; p53

Indexed keywords

PROTEIN BCL 2; PROTEIN P53;

ADENOMA; ADJUVANT THERAPY; ARTICLE; COLON ADENOMA; COLORECTAL CANCER; COLORECTAL CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NEOPLASM; PRIORITY JOURNAL; STAINING; TUMOR SUPPRESSOR GENE;

EID: 0029869360     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.178     Document Type: Article

References (30)

1. AYHAN A, YASUI W, YOKOZAKI H, SETO M, UEDA R AND TAHARA E. (1994). Loss of heterozygosity at the bcl-2 gene locus and expression of bcl-2 in human gastric and colorectal carcinomas. Jpn. J. Cancer Res., 85, 584-591.
2. BAKER SJ, PREISINGER AC, JESSUP JM, PARASKEVA C, MARKOWITZ S, WILLSON JKV, HAMILTON S AND VOGELSTEIN B. (1990). p53 gene mutations occur in combination with p17 allelic deletions as late events in colorectal tumorigenesis. Cancer Res., 50, 7717-7722.
3. BRONNER MP, CULIN C, REED JC AND FURTH EE. (1995). The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. Am. J. Pathol., 146, 20-26.
4. DIVE C, PULLAN S, WILSON J, HICKMAN J, TILLY J AND STREULI C. (1995). Requirement of basement membrane for the suppression of apoptosis in mammary epithelium. Proc. Am. Assoc. Cancer, 36, 1.
5. FARROW SN, WHITE JHM, MARTINOU I, RAVEN T, PUN K, GRINHAM CJ, MARTINOU J AND BROWN R. (1995). Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. Nature, 374, 731-733.
6. FISHER TC, MILNER AE, GREGORY CD, JACKMAN AL, AHERNE GW, HARTLEY JA, DIVE C AND HICKMAN JA. (1993). bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways. Cancer Res., 53, 3321-3326.
7. FISHER CJ, GILLETT CE, VOJTESEK B, BARNES DM AND MILLIS RR. (1994). Problems with p53 immunohistochemical staining: the effect of fixation and variation in the methods of evaluation. Br. J. Cancer, 69, 26-31.
8. HAGUE A, MOORGHEN M, HICKS D, CHAPMAN M AND PARASKEVA C. (1994). BCL-2 expression in human colorectal adenomas and carcinomas. Oncogene, 9, 3367-3370.
9. HALDAR S, NEGRINI M, MONNE M, SABBIONI S AND CROCE CM. (1994). Down-regulation of bcl-2 and p53 in breast cancer cells. Cancer Res., 54, 2095-2097.
10. HALL PA AND LANE DP. (1994). p53 in tumour pathology: can we trust immunohistochemistry? - revisited! J. Pathol., 172, 1-4.
11. HOCKENBURY DM, ZUTTER M, HICKHEY B, NAHM M AND KORSMEYER SJ. (1991). Bcl-2 protein is topographically restricted in tissues characterised by apoptotic cell death. Proc. Natl Acad. Sci. USA, 88, 6961-6965.
12. JASS JR, ATKIN WS, CUZICK J, BUSSEY HJ, MORSON BC, NORTH-OVER JM AND TODD IP. (1986). The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathology, 10, 437-459.
13. JEN J, KIM H, PIANTADOSI S, LIU Z-F, LEVITT RC, SISTONEN P, KINZLER KW, VOGELSTEIN B AND HAMILTON SR. (1994). Allelic loss of chromosome 18q and the prognosis in colorectal cancer. N. Engl. J. Med., 331, 213-221.
14. KORSMEYER SJ. (1992). Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood, 80, 879-886.
15. LU QL, HANBY AM, NASSER-HAJIBAGHERI MA, GSCHMEISSNER SE, LU PJ, TAYLOR-PAPADIMITRIOU J, KRAJEWSKI S, REED JC AND WRIGHT NA. (1994). Bcl-2 protein localises to the chromosomes of mitotic nuclei and is correlated with the cell cycle in cultured epithelial cell lines. J. Cell. Sci., 107, 363-371.
16. MARIN MC, HSU B, MEYN RE, DONEHOWER LA, EL-NAGGAR AK AND MCDONNELL TJ. (1994). Evidence that p53 and bcl-2 are regulators of a common cell death pathway important for in vivo lymphomagenesis. Oncogene, 9, 3107-3112.
17. MERRITT AJ, POTTEN CS, KEMP CJ, HICKMAN JA, BALMAIN A, LANE DP AND HALL PA. (1994). The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res., 54, 614-617.
18. MERRITT AJ, POTTEN CS, WATSON AJM, LOH DY, NAKAYAMA K, NAKAYAMA K AND HICKMAN JA. (1995). Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J. Cell. Sci., 108, 2261-2271.
19. MIYASHITA T, HARIGAI M, HANADA M AND REED JC. (1994a). Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res., 54, 3131-3135.
20. MIYASHITA T, KRAJEWSKI S, KRAJEWSKI M, WANG HG, LIN HK, LIEBERMANN DA, HOFFMAN B AND REED JC. (1994b). Tumour suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene, 9, 1799-1805.
21. ÖFNER D, REIHEMANN K, MAIER H, RIEDMANN B, NEHODA H, TÖTSCH M, BÖCKER W, JASANI B AND SCHMID KW. (1995). Immunohistochemically detectable bcl-2 expression in colorectal carcinoma: correlation with tumour stage and patient survival. Br. J. Cancer, 72, 981-985.
22. OLTVAI ZN, MILLIMAN CL AND KORSMEYER SJ. (1993). Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell, 74, 609-619.
23. OSHIMA M, OSHIMA H, KITAGAWA K, KOBAYASHI M, ITAKURA C AND TAKETO M. (1995). Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc. Natl Acad. Sci., 92, 4482-4486.
24. PIETENPOL JA, PAPADOPOULOS N, MARKOWITZ S, WILLSON JKV, KINZLER KW AND VOGELSTEIN B. (1994). Paradoxical inhibition of solid tumour cell growth by bcl-2. Cancer Res., 54, 3714-3717.
25. POTTEN CS. (1992). The significance of spontaneous and induced apoptosis in the gastrointestinal tract. Cancer Met. Rev., 11, 179-195.
26. POTTEN CS, LI YQ, O'CONNOR PJ AND WINTON DJ. (1992). A possible explanation for the differential cancer incidence in the intestine, based on the distribution of cytotoxic effects of carcinogens in the murine large bowel. Carcinogenesis, 13, 2305-2312.
27. SELVAKUMARAN M, LIN HK, MIYASHITA T, WANG HG, KRAJEWSKI S, REED JC, HOFFMAN B AND LIEBERMANN D. (1994). Immediate early up-regulation of bax expression by p53 but not TGF-beta 1: a paradigm for distinct apoptotic pathways. Oncogene, 9, 1791-1798.
28. SINICROPE FA, RUAN SB, CLEARY KR, STEPHENS LC, LEE JJ AND LEVIN B. (1995). bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res., 55, 237-241.
29. TSUJIMOTO Y, GORHAM J, COSSMAN J, JAFFE E AND CROCE CM. (1985). The t(14:18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science, 229, 1390-1393.
30. WATSON AJM. (1995). Manipulation of cell death - the development of novel strategies for the treatment of gastrointestinal disease. Aliment. Pharmacol. Ther., 9, 215-226.