Combined CXCR3/CCR5 blockade attenuates acute and chronic rejection

Journal of Immunology

Volumn 180, Issue 7, 2008, Pages 4714-4721

  Schnickel, Gabriel T ^a,b   Bastani, Sam ^a,b   Hsieh, George R ^a,b   Shefizadeh, Ali ^a   Bhatia, Rubina ^a   Fishbein, Michael C ^a   Belperio, John ^a   Ardehali, Abbas ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR5; TRANSCRIPTION FACTOR FOXP3; ALLOANTIGEN; CHEMOKINE RECEPTOR CCR5; CXCR3 PROTEIN, MOUSE; CYTOKINE;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GRAFT SURVIVAL; HEART; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; ACUTE DISEASE; ANIMAL; CELL PROLIFERATION; CHRONIC DISEASE; CYTOLOGY; GENETICS; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOLOGY; SPLEEN;

ACUTE DISEASE; ANIMALS; CELL PROLIFERATION; CHRONIC DISEASE; CYTOKINES; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; ISOANTIGENS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, KNOCKOUT; RECEPTORS, CCR5; RECEPTORS, CXCR3; SPLEEN;

EID: 44449122387     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.7.4714     Document Type: Article

References (33)

1. Hancock, W. W. 2003. Chemokine receptor-dependent alloresponses. Immunol. Rev. 196: 37-50.
2. Sallusto, F., C. R. Mackay, and A. Lanzavecchia. 2000. The role of chemokine receptors in primary effector, and memory responses. Annu. Rev. Immunol. 18: 593-620.
3. Miura, M., K. Morita, H. Kobayashi, T. A. Hamilton, M. D. Burdick, R. M. Strieter, and R. L. Fairchild. 2001. Monokine induced by IFN-γ is a dominant factor directing T cells to murine cardiac allografts during acute rejection. J. Immunol. 16: 3494-3504.
4. Gao, W., K. L. Faia, V. Csizmadia, S. T. Smiley, D. Soler, J. A. King, T. M. Danoff, and W. W. Hancock. 2001. Beneficial effects of targeting CCR5 in allograft recipients. Transplantation 72: 1199-1205.
5. Morita, K., M. Miura, D. R. Paolone, M. Engeman, A. Kappor, D. G. Remick, and R. L. Fairchild. 2001. Early chemokine cascades in murine cardiac grafts regulate T cell recruitment and progression of acute allograft rejection. J. Immunol. 167: 2979-2984.
6. Hancock, W. W., B. Lu, W. Gao, V. Csizmadia, K. Faia, J. A. King, S. T. Smiley, M. Ling, N. P. Gerard, and C. Gerard. 2000. Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J. Exp. Med. 192: 1515-1520.
7. Abdi, R., R. N. Smith, L. Makhlouf, N. Najafian, A. D. Luster, H. Auchincloss, and M. H. Sayegh. 2002. The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection. Diabetes 51: 2489-2495.
8. Yun, J. J., M. P. Fischbein, D. Whiting, Y. Irie, M. C. Fishbein, M. D. Burdick, J. Belperio, R. M. Strieter, H. Laks, J. A. Berliner, and A. Ardehali. 2002. The role of MIG/CXCL9 in cardiac allograft vasculopathy. Am. J. Pathol. 161: 1307-1313.
9. Belperio, J. A., M. P. Keane, M. D. Burdick, J. P. Lynch, D. A. Zisman, Y. Y. Xue, K. Li, A. Ardehali, D. J. Ross, and R. M. Strieter. 2003. Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection. J. Immunol. 171: 4844-4852.
10. Abdi, R., T. K. Means, T. Ito, R. N. Smith, N. Najafian, M. Jurewicz, V. Tchipachvili, I. Charo, H. Auchincloss, M. H. Sayegh, and A. D. Luster. 2004. Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo. J. Immunol. 171: 767-775.
11. Yun, J. J., D. Whiting, M. P. Fischbein, A. Banerji, Y. Irie, D. Stein, M. C. Fishbein, A. E. Proudfoot, H. Laks, J. A. Berliner, and A. Ardehali. 2004. Combined blockade of the chemokine receptors CCR1 and CCR5 attenuates chronic rejection. Circulation 109: 932-937.
12. Fahmy, N. M., M. H. Yamani, R. C. Starling, N. B. Ratliff, J. B. Young, P. M. McCarthy, J. Feng, A. C. Novick, and R. L. Fairchild. 2003. Chemokine and receptor-gene expression during early and late acute rejection episodes in human cardiac allografts. Transplantation 75: 2044-2047.
13. Zhao, D. X., Y. Hu, G. G. Miller, A. D. Luster, R. N. Mitchell, and P. Libby. 2002. Differential expression of the IFN-γ-inducible CXCR3-binding chemo-kines, IFN-inducible protein 10, monokine induced by IFN, and IFN-inducible T cell α chemoattractant in human cardiac allografts: association with cardiac al-lograft vasculopathy and acute rejection. J. Immunol. 169: 1556-1560.
14. Hancock, W. W., W. Gao, V. Csizmadia, K. L. Faia, N. Shemmeri, and A. D. Luster. 2001. Donor-derived IP-10 initiates development of acute allograft rejection. J. Exp. Med. 193: 975-980.
15. Corry, R., H. Winn, and P. Russell. 1973. Primarily vascularized allografts of hearts in mice: the role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 16: 343-350.
16. Belperio, J. A., M. P. Keane, M. D. Burdick, J. P. Lynch, Y. Y. Xue, K. Li, D. J. Ross, and R. M. Strieter. 2002. Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. J. Immunol. 169: 1037-1049.
17. Belperio, J. A., M. P. Keane, M. D. Burdick, J. P. Lynch, Y. Y. Xue, A. Berlin, D. J. Ross, S. L. Kunkel, I. F. Charo, and R. M. Strieter. 2001. Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. J. Clin. Invest. 108: 547-556.
18. + precursors in a thymus-independent process. J. Immunol 172: 923-928.
19. Hubeau, C., I. Apostolou, and L. Kobzik. 2007. Targeting of CD25 and glu-cocorticoid induced TNF receptor family-related gene-expressing T cells differentially modulates asthma risk in offspring of asthmatic and normal mother mice. J. Immunol. 178: 1477-1478.
20. + cells, and the alloreactive T cell clone size. J. Immunol. 169: 3744-3751.
21. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Synthesis of RNA probes by in vitro transcription of double-stranded DNA templates by bacteriophage DNA-dependent RNA polymerases. In Molecular Cloning: A Laboratory Manual, 2nd Ed. N. Ford, C. Nolan, and M. Ferguson, eds. Cold Spring Harbor Lab. Press, New York, pp. 10.27-10.37.
22. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
23. + suppressor cells and its mechanism of action. J. Exp. Med. 171: 141-157.
24. +regulatory cells mediate dominant transplantation tolerance. J. Immunol. 168: 5558-5565.
25. + regulatory T cells prevent graft rejection: CTLA-4-and IL-10-dependent immu-noregulation of alloresponses. J. Immunol. 168: 1080-1086.
26. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immuno-logic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164.
27. + T cells. J. Immunol. 174: 3741-3748.
28. Heller, E. A., E. Liu, A. M. Tager, Q. Yuan, A. Y. Lin, N. Ahluwalia, K. Jones, S. L. Koehn, V. M. Lok, E. Aikawa, et al. 2006. Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation 113: 2301-2312.
29. Whiting, D., G. Hsieh, J. J. Yun, A. Banerji, W. Yao, M. C. Fishbein, J. Belperio, R. M. Strieter, B. Bonavida, and A. Ardehali. 2004. Chemokine monokine induced by IFN-γ/CXC chemokine ligand 9 stimulates T lymphocyte proliferation and effector cytokine production. J. Immunol. 172: 7417-7424.
30. + T cell-mediated inflammation in the central nervous system of virus-infected mice. J. Immunol. 175: 1767-1775.
31. Tokuyama, H., S. Ueha, M. Kurachi, K. Matsushima, F. Moriyasu, R. S. Blumberg, and K. Kakimi. 2005. The simultaneous blockade of chemokine receptor CCR2, CCR5, and CXCR3 by a non-peptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis. Int. Immunol. 17: 1023-1034.
32. + T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. J. Exp. Med. 201: 1037-1044.
33. + regulatory T cells. J. Exp. Med. 194: 847-853.