Noninvasive measurement of protein aggregation by mutant huntingtin fragments or α-synuclein in the lens

Journal of Biological Chemistry

Volumn 283, Issue 10, 2008, Pages 6330-6336

  Muchowski, Paul J ^a,c   Ramsden, Richard ^a   Nguyen, Quangvu ^a   Arnett, Ernest E ^b   Greiling, Teri M ^b   Anderson, Susan K ^b   Clark, John I ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEINS; IMAGING TECHNIQUES; LENSES; OPTICAL INSTRUMENTS; PLANTS (BOTANY);

ALZHEIMER; AMYLOID FORMATIONS; CATARACT FORMATIONS; CHAPERONE ACTIVITIES; CRYSTALLIN; FIBRILLAR STRUCTURES; HIGHLY SENSITIVES; HUMAN DISEASES; IN-VIVO; INVASIVE METHODS; MICE LACKING; MOUSE MODELS; MUTANT HUNTINGTIN; NEURODEGENERATION; NONINVASIVE MEASUREMENTS; OCULAR LENSES; OPTICAL TECHNIQUES; PARKINSON DISEASES; PROTEIN AGGREGATIONS; PROTEIN INTERACTIONS; REAL TIMES; SYNUCLEIN; TRANSGENIC MOUSE;

AGGLOMERATION;

ALPHA SYNUCLEIN; CRYSTALLIN; HUNTINGTIN; ALPHA CRYSTALLIN; HUNTINGTON PROTEIN, MOUSE; NERVE PROTEIN; NUCLEAR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CELL INCLUSION; CONTROLLED STUDY; LENS; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRANSGENIC MOUSE; ALZHEIMER DISEASE; ANIMAL; DISEASE MODEL; GENE EXPRESSION; GENETICS; HUNTINGTON CHOREA; METABOLISM; MUTATION; PARKINSON DISEASE; PATHOLOGY;

MUS; MUS MUSCULUS;

ALPHA-CRYSTALLIN B CHAIN; ALPHA-SYNUCLEIN; ALZHEIMER DISEASE; ANIMALS; CATARACT; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HUNTINGTON DISEASE; LENS, CRYSTALLINE; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PARKINSON DISEASE;

EID: 44449119580     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709678200     Document Type: Article

References (21)

1. The Huntington's Disease Collaborative Research Group (1993) Cell 72, 971-983
2. DiFiglia, M., Sapp, E., Chase, K. O., Davies, S. W., Bates, G. P., Vonsattel, J. P., and Aronin, N. (1997) Science 277, 1990-1993
3. Goedert, M. (2001) Nat. Rev. Neurosci. 2, 492-501
4. Kruger, R. (2004) J. Neurol. 251, Suppl. 6, VI/2-6
5. Dobson, C. M. (2003) Nature 426, 884-890
6. Taylor, J. P., Hardy, J., and Fischbeck, K. H. (2002) Science 296, 1991-1995
7. Kazantsev, A., Preisinger, E., Dranovsky, A., Goldgaber, D., and Housman, D. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11404-11409
8. Mahon, K. A., Chepelinsky, A. B., Khillan, J. S., Overbeek, P. A., Piatigorsky, J., and Westphal, H. (1987) Science 235, 1622-1628
9. Taube, J. R., Gao, C. Y., Ueda, Y., Zelenka, P. S., David, L. L., and Duncan, M. K. (2002) Transgenic Res. 11, 397-410
10. Outeiro, T. F., and Lindquist, S. (2003) Science 302, 1772-1775
11. Seeberger, T. M., Matsumoto, Y., Alizadeh, A., Fitzgerald, P. G., and Clark, J. I. (2004) J. Biomed. Opt. 9, 116-120
12. Goldstein, L. E., Muffat, J. A., Cherny, R. A., Moir, R. D., Ericsson, M. H., Huang, X., Mavros, C., Coccia, J. A., Faget, K. Y., Fitch, K. A., Masters, C. L., Tanzi, R. E., Chylack, L. T., Jr., and Bush, A. I. (2003) Lancet 361, 1258-1265
13. Scherzinger, E., Lurz, R., Turmaine, M., Mangiarini, L., Hollenbach, B., Hasenbank, R., Bates, G. P., Davies, S. W., Lehrach, H., and Wanker, E. E. (1997) Cell 90, 549-558
14. Burke, J. R., Enghild, J. J., Martin, M. E., Jou, Y. S., Myers, R. M., Roses, A. D., Vance, J. M., and Strittmatter, W. J. (1996) Nat. Med. 2, 347-350
15. Clark, J. I., and Muchowski, P. J. (2000) Curr. Opin. Struct. Biol. 10, 52-59
16. Brady, J. P., Garland, D. L., Green, D. E., Tamm, E. R., Giblin, F. J., and Wawrousek, E. F. (2001) Investig. Ophthalmol. Vis. Sci. 42, 2924-2934
17. Rochet, J. C., Outeiro, T. F., Conway, K. A., Ding, T. T., Volles, M. J., Lashuel, H. A., Bieganski, R. M., Lindquist, S. L., and Lansbury, P. T. (2004) J. Mol. Neurosci. 23, 23-34
18. Ansari, R. R., King, J. F., Seeberger, T., and Clark, J. I. (2003) Proc. SPIE 4951 (Ophthalmic Technology XIII), 168-176
19. Levine, M. S., Cepeda, C., Hickey, M. A., Fleming, S. M., and Chesselet, M. F. (2004) Trends Neurosci. 27, 691-697
20. Hiraoka, T., Clark, J. I., Li, X. Y., and Thurston, G. M. (1996) Exp. Eye Res. 62, 11-19
21. Hiraoka, T., and Clark, J. I. (1995) Investig. Ophthalmol. Vis. Sci. 36, 2550-2555