αB-crystallin in lens development and muscle integrity: A gene knockout approach

Investigative Ophthalmology and Visual Science

Volumn 42, Issue 12, 2001, Pages 2924-2934

  Brady, J P ^a   Garland, D L ^a   Green, D E ^a   Tamm, E R ^a   Giblin, F J ^a   Wawrousek, E F ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; CHAPERONE; BACTERIAL PROTEIN; CRYSTALLIN; HEAT SHOCK PROTEIN; HSPB PROTEIN, HELICOBACTER PYLORI; MESSENGER RNA;

ANIMAL TISSUE; ARTICLE; CATARACT; CILIARY MUSCLE; EYE DEVELOPMENT; GEL ELECTROPHORESIS; GENE STRUCTURE; GENE TARGETING; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LENS; MOUSE; NONHUMAN; NORTHERN BLOTTING; OXIDATIVE STRESS; PRIORITY JOURNAL; SLIT LAMP; SOUTHERN BLOTTING; THERMOSTABILITY; AGING; ANIMAL; GENE DELETION; GROWTH, DEVELOPMENT AND AGING; KYPHOSIS; METABOLISM; MOUSE MUTANT; MUSCULAR DYSTROPHY; PATHOLOGY; PHYSIOLOGY; SKELETAL MUSCLE; TWO DIMENSIONAL GEL ELECTROPHORESIS;

AGING; ANIMALS; BACTERIAL PROTEINS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CRYSTALLINS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE DELETION; HEAT-SHOCK PROTEINS; KYPHOSIS; LENS, CRYSTALLINE; MICE; MICE, KNOCKOUT; MOLECULAR CHAPERONES; MUSCLE, SKELETAL; MUSCULAR DYSTROPHIES; OXIDATIVE STRESS; RNA, MESSENGER;

EID: 0034740261     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

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2. Binding of actin to lens α-crystallins
3. αB-crystallin in cardiac tissue: Association with actin and desmin filaments
4. α-crystallin stabilizes actin filaments and prevents cytochalasin-induced depolymerization in a phosphorylation dependent manner
5. Chaperone activity of α-crystallins modulates intermediate filament assembly
6. α-crystallins are involved in specific interactions with the murine gamma D/E/F-crystallin-encoding gene
7. α-crystallin can function as a molecular chaperone
8. αB-crystallin is a small heat shock protein
9. Hypertonic stress induces αB-crystallin expression
10. Copurification of small heat shock protein with αB-crystallin from human skeletal muscle
11. αA-crystallin is expressed in non-ocular tissues
12. αA- and αB-crystallin in the retina: Association with the post-Golgi compartment of frog retinal photoreceptors
13. αB subunit of lens-specific protein α-crystallin is present in other ocular and non-ocular tissues
14. Expression of the murine αB-crystallin gene is not restricted to the lens
15. Cellular distribution of αB-crystallin in non-lenticular tissues
16. Spatial and temporal activity of the αB-crystallin/small heat shock protein gene promoter in transgenic mice
17. Temporospatial expression of the small HSP/αB-crystallin in cardiac and skeletal muscle during mouse development
18. Expression of the α-crystallin/small heatshock protein/molecular chaperone genes in the lens and other tissues
19. A new familial muscular disorder demonstrated by the intra-sarcoplasmic accumulation of a granulo-filamentous material which is dense on electron microscopy
20. A missense mutation in the αB-crystallin chaperone gene causes a desmin-related myopathy
21. Targeted disruption of the mouse αA-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein αB-crystallin
22. Identification and characterization of the gene encoding a new member of the α-crystallin/small hsp family, closely linked to the αB-crystallin gene in a head-to-head manner
23. MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase
24. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
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27. Hyperbaric oxygen in vivo accelerates the loss of cytoskeletal proteins and MIP26 in guinea pig lens nucleus
28. Nuclear light-scattering, disulfide formation and membrane damage in lenses of older guinea-pigs treated with hyperbaric-oxygen
29. Nuclear cataract and myopia during hyperbaric-oxygen therapy
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32. Differential protective activity of αA- and αB-crystallin in lens epithelial cells
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35. Intermolecular exchange and stabilization of recombinant human αA- and αB-crystallin
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37. Thermodynamic stability of human lens recombinant αA- and αB-crystallins
38. Heat-induced conformational change of human lens recombinant αA- and αB-crystallins
39. 2 but phosphorylation has no effect on chaperone activity
40. Chaperone function of mutant versions of αA- and αB-crystallin prepared to pinpoint chaperone binding sites
41. Studies of the denaturation patterns of bovine α-crystallin using an ionic denaturant, guanidine hydrochloride and a non-ionic denaturant, urea
42. Conversion from oligomers to tetramers enhances autophosphorylation by lens αA-crystallin: Specificity between αA- and αB-crystallin subunits
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44. Inherited cataracts in inbred mice
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46. αB-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain
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48. Expression of αB-crystallin in Alzheimer's disease
49. The molecular chaperone αB-crystallin enhances amyloid beta neurotoxicity
50. Ser-59 is the major phosphorylation site in αB-crystallin accumulated in the brains of patients with Alexander's disease
51. Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation
52. Fiber-type-specific αB-crystallin distribution and its shifts with T-3 and PTU treatments in rat hindlimb muscles
53. αB-crystallin in skeletal muscle: Purification and localization
54. Storage of phosphorylated desmin in a familial myopathy
55. Mutation R120G in αB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function
56. Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice
57. Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy