Effect of selected anti-cataract agents on opacification in the selenite cataract model

Experimental Eye Research

Volumn 62, Issue 1, 1996, Pages 11-20

  Hiraoka, T ^a,d   Clark, J I ^a,b   Li, X Y ^c   Thurston, G M ^c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Oculon Corporation   (United States)

^d DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

anti cataract agents; cataract; lens; phase separation; selenite model

Indexed keywords

AMIFOSTINE; AMINOGUANIDINE; ANTICATARACT AGENT; ASCORBIC ACID; CYSTAMINE; DEFEROXAMINE; GLUTATHIONE; GLUTATHIONE ISOPROPYL ESTER; PANTETHINE; PENICILLAMINE; PHOSPHOROTHIOIC ACID S (3 AMINO 2 HYDROXYPROPYL) ESTER; SELENITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATARACT; CATARACTOGENESIS; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029874158     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.1996.0002     Document Type: Article

References (69)

1. Abraham, E. C., Cherian, M., Abraham, A. and Swamy, M. S. (1994). Glycation of lens crystalling. Exp. Eye Res. 59 (Suppl. 1), S.129.
2. Al-Ghoul, K. J. and Costello, M. J. (1993). Morphological changes in human nuclear cataracts of late-onset diabetes. Exp. Eye Res. 57, 469-86.
3. Anderson, R. S., Shearer, T. R. and Claycomb, C. K. (1986). Selenite-induced epithelial damage and cortical cataract. Curr. Eye Res. 5, 53-61.
4. Benedek, G. B. (1971). Theory of transparency of the eye. Appl. Optics. 10, 459-73.
5. Bettelheim, F. A. (1985). Physical basis of lens transparency. In The Ocular Lens: Structure, Function and Pathology (Ed. Maisel, H.). pp. 265-300. Marcel Dekker: New York, U.S.A.
6. Bunce, G. E., Hess, J. L. and Batra, R. (1984). Lens calcium and selenite-induced cataract. Curr. Eye Res. 3, 315-20.
7. Calvin, H. I., Medvedovsky, C., David, J. C., Braglia, T. M., Hess, J. L., Fu, S.-C. J. and Worgul, B. V. (1991). Rapid deterioration of lens fibers in GSH-depleted mouse pups. Invest. Ophthalmol. Vis. Sci. 32, 1916-24.
8. Cenedella, R. J. (1987). Direct chemical measurement of DNA synthesis and net rates of differentiation of rat lens epithelial cells in vivo : applied to the selenium cataract. Exp. Eye Res. 44, 677-90.
9. Clark, J. I. and Benedek, G. B. (1980a). The effects of glycols, aldehydes, and acrylamide on phase separation and opacification in the calf lens. Invest. Ophthalmol. Vis. Sci 19, 771-6.
10. Clark, J. I. and Benedek, G. B. (1980b). Phase diagram for cell cytoplasm from the calf lens. Biochem. Biophys. Res. Commun. 95, 482-9.
11. Clark, J. I., Delaye, M., Hammer, P. and Mengel, L. (1981). Preparation and characterization of native lens cell cytoplasm. Curr. Eye Res. 1, 695-704.
12. Clark, J. I., Giblin, F. J., Reddy, V. N. and Benedek, G. B. (1982). Phase separation in x-irradiated lenses of rabbit. Invest. Ophthalmol Vis. Sci. 22, 186-90.
13. Clark, J. I., Livesey, J. C., Steele, J. E. (1993). Phase separation inhibitors and lens transparency. Optom. Vis. Sci. 70, 873-9.
14. Clark, J. I. (1994a). Lens cytoplasmic protein solutions: analysis of a biologically occurring aqueous phase separation. Methods Enzymol. 228, 525-37.
15. Clark, J. I. (1994b). Development and maintenance of lens transparency. In Principles and Practice of Ophthalmology (Eds E. M. Alberts and F. A. Jakobiec). Pp. 114-123. W. B. Saunders: Philadelphia, U.S.A.
16. Clark, J. I., Steele, J. E. and Livesey, J. C. (1992). Phase separation inhibitors, P.S.I, and the inhibition of cataract in rats. Invest. Ophthalmol. Vis. Sci. 33, 868a.
17. Clark, J. I. and Carper, D. (1987). Phase separation in lens cytoplasm in genetically linked to cataract formation in the Philly mouse. Proc. Natl. Acad. Sci., USA 84, 122-5.
18. Clark, J. I., Osgood, T. B. and Trask, S. J. (1987). Inhibition of phase separation by reagents that prevent x-irradiation cataract in vivo. Exp. Eye Res. 45, 961-7.
19. Clark, J. I. (1990). Phase separation and hydrogen bonding in cells of the ocular lens. Biopolymers 30, 995-9.
20. Clark, J. I. and Steele, J. E. (1992). Phase-separation inhibitors and prevention of selenite cataract. Proc Natl. Acad. Sci., USA 89, 1720-4.
21. Crompton, M., Rixon, K. C. and Harding, J. J. (1985). Aspirin prevents carbamylation of soluble lens proteins and prevents cyanate-induced phase separation opacities in vitro; a possible mechanism by which aspirin could prevent cataract. Exp. Eye Res. 40, 297-311.
22. Davies, S. C., Hungerford, J. L., Arden, G. B., Marcus, R. E., Miller, M. H. and Huehns, E. R. (1983). Ocular toxicity of high dose intravenous desferrioxamine. Lancet ii, 181-4.
23. DeDuve, C. (1991). Blueprint for a Cell. Neil Patterson Publications: Burlington, U.S.A.
24. Devamanoharen, P. S., Henein, M., Morris, S., Ramachandran, S., Richards, R. D. and Varma, S. D. (1991). Prevention of selenite cataract by vitamin C. Exp. Eye Res. 52, 563-8.
25. Eccarius, S. and Clark, J. I. (1987). Effect of aspirin and vitamin E on phase separation in calf lens homogenate. Ophthalmic Res. 19, 65-71.
26. Francois, P. J. and Beheyt, J. (1955). Cataracte par rayons X et cysteamine. Ophthalmologica 130, 397-402.
27. Gupta, S. K. and Joshi, S. (1994). Role of Naproxen as anti-oxidant in selenite cataract. Ophthalmic Res. 26, 226-31.
28. Harding, J. (1991). Cataract: biochemistry, epidemiology and pharmacology. Chapman & Hall : London.
29. Harding, C. V., Jr., Susan, S. R., Lo, W.-K. and Bobrowski, W. F. (1985). The structure of the human cataractous lens. In The Ocular Lens, Structure, Function and Pathology, (Ed. Maisel H.) p. 367. Marcel Dekker: New York, U.S.A.
30. Hiraoka, T. and Clark, J. I. (1995). Inhibition of lens opacification during the early stages of cataract formation Invest. Ophthalmol. Vis. Sci. 36, 2550-5.
31. Huang, L., Hess, J. L. and Bunce, G. E. (1990). DNA damage, repair, and replication in selenite-induced cataract in rat lens. Curr. Eye Res. 9, 1041-50.
32. Ishimoto, I., Goalwin, P. W., Sun, S. T., Mishio, I. and Tanaka, T. (1979). Cytoplasmic phase separation in formation of galactosemic cataract in lenses of young rats. Proc. Natl. Acad. Sci., USA 76, 4414-16.
33. Jaffe, I.A. (1979). Penicillamine. In Pharmacological and Biochemical Properties of Drug Substances, Vol. 2 (Ed. Goldberg, M.E.) Pp. 465-478. American Pharmaceutical Association, Washington, U.S.A.
34. Kobayashi, S., Kasuya, M., Shimizu, K., Ishii, Y., Takehana, M., Sakai, K., Suzuki, N. and Itoi, M. (1993). Glutathione isopropyl ester (YM737) inhibits the progression of X-ray-induced cataract in rats. Curr. Eye Res. 12, 115-22.
35. Kuck, J. F., Jr. and Kuck, K. D. (1988). The emory mouse cataract: The effects on cataractogenesis of a-tocopherol, penicillamine, triethylenetetramine, and mercaptopropionylglycine. J. Ocular Pharmacol. 4, 243-51.
36. Lewis, B. S. and Harding, J. (1990). The effects of amino-guanidine on the glycation (non-enzymic glycosylation) of lens protein. Exp. Eye Res. 50, 463-7.
37. Lipmann, F. (1971). Attempts to map a process evolution to peptide biosynthesis. Science 173, 875-84.
38. Livesey, J. C. and Reed, D. J. (1987). Chemical protection against ionizing radiation. Adv. Radiat. Biol. 13, 285-353.
39. Livesey, J. C., Wiens, L. W., Von Seggern, D. J., Barlow, W. E. and Arnold, A. M. (1995). Inhibition of radiation cataractogenesis by WR-77913. Radiation Res. 141, 99-104.
40. 2+-treated lens. Invest. Ophthalmol Vis. Sci. 28, 1218-22.
41. Lou, M. F., Dickerson, J. E. and Garadi, R. (1990). The role of protein-thiol mixed disulfides in cataractogenesis. Exp. Eye Res. 50, 819-26.
42. Menard, T. W., Osgood, T. B., Clark, J. I., Spence, A. M., Steele, J. E., Krohn, K. A., Livesey, J. C. (1986). Radio-protection against cataract formation by WR-77913 in gamma-irradiated rats. Int. J. Radiation Oncol. Biol. Phys. 12, 1483-6.
43. Miesbauer, L. R., Zhou, X., Yang, Z., Sun, Y., Smith, D. L. and Smith, J. B. (1994). Post-translational modifications of water-soluble human lens crystallins from young adults. J. Biol. Chem. 269, 12494-502.
44. Nishigori, H., Hayashi, R., Lee, J. W. and Iwatsuru, M. (1984). Effect of MPG on glucocorticoid-induced cataract formation in developing chick embryo. Invest. Ophthal Vis. Sci. 25, 1051-5.
45. Olivieri, N. F., Buncic, J. R., Chew, E., Gallant, T., Harrison, R. V., Keenan, B. A., Logan, W., Mitchell, D., Ricci, G., Skarf, B., Taylor, M. and Freedman, M. H. (1986). Visual and auditory neurotoxicity in patients receiving subcutaneous deferoxamine infusions. N. Engl. J. Med. 314, 869-73.
46. Osgood, T. B., Menard, T. W., Clark, J. I. Krohn, K. A. (1986). Inhibition of lens opacification in x-irradiated rats treated with WR-77913. Invest. Ophthalmol. Vis. Sic. 27, 1780-4.
47. Ostadalova, I., Babicky, A. and Obenberger, J. (1978). Cataract induced by administration of a single dose of sodium selenite to sucking rats. Experimentia 34, 222-3.
48. Pande, J., Ogun, O., Nath, C., and Benedek, G. (1993). Suppression of phase separation in bovine γIV crystallin solutions: Effect of modification by charged versus uncharged polar groups. Exp. Eye Res. 57, 257-264.
49. Pande, J., McGiffert, C., Ogun, O., Sokolinsky, I. and Benedek, G. (1994). Protein-thiol mixed disulfides and lens opacification. Invest. Ophthalmol. Vis. Sci. 35, 1810a.
50. Pande, J., Berland, C., Broide, M., Ogun, O., Melhuish, J. and Benedek, G. B. (1991). Suppression of phase separation in solutions of bovine γIV-crystallin by polar modification of the sulfur-containing amino acids. Proc. Natl. Acad. Sci., USA 88, 4916-20.
51. Qin, W., Smith, J. B. and Smith, D. L. (1993). Reaction of aspirin with cysteinyl residues of lens γ-crystallins : a mechanism for the proposed anti-cataract effect of aspirin. Biochem Biophys. Acta 1181, 103-10.
52. 2-induced injury. Lens Eye Toxicity Res. 9, 385-93.
53. Reddan, J., Sevilla, M., Giblin, F., Padgaonkar, V., Dziedzic, D. and Leverenz, V., Misra, I. C. and Peters, J. L. (1993). The superoxiode dismutase mimic tempol protects cultured rabbit lens epithelial cells from hydrogen peroxide insult. Exp. Eye Res. 56, 543-54.
54. Reddy, V. N., Ikebe, H., Giblin, F. J., Clark, J. I. and Livesey, J. C. (1989). Effect of radioprotective agents on x-ray cataracts. Lens Eye Toxicity Res. 6, 573-88.
55. Saika, S. (1993). Ascorbic acid and proliferation of cultured rabbit keratocytes. Cornea 12, 191-8.
56. Saika, S., Uenoyama, K., Hiroi, K., Tanioka, H., Takase, K. and Hikita, M. (1993). Ascorbic acid phosphate ester and wound healing in rabbit corneal alkali burns: epithelial basement membrane and stroma. Graefe's Arch. Clin. Exp. Ophthalmol 231, 221-7.
57. Sasaki, K., Kuriyama, H., Yeh, L. I. and Fukuda, M. (1983). Studies on diabetic cataract in rats induced by streptozotocin. Ophthalmic. Res. 15, 185-90.
58. Shearer, T. R., David, L. L., Anderson, R. S. and Azuma, M. (1992). Review of selenite cataract. Curr. Eye Res. 11, 357-69.
59. Shearer, T. R., David, L. L. and Anderson, R. S. (1987). Selenite cataract: a review. Curr. Eye Res. 6, 289-300.
60. Shearer, T. R., Azuma, M., David, L. L. and Murachi, T. (1991). Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64. Invest. Ophthalmol. Vis. Sci. 32, 533-40.
61. Siezen, R. J., Coppin, S. M. and Benedek, G. B. (1985). Permanent suppression of phase separation cataract in calf lens using amine modification agents. Biochem. Biophys. Res. Comm. 133, 239-47.
62. Tanaka, T., Ishimoto, C. and Chylack, L. T. (1977). Phase separation of a protein-water mixture in cold cataract in the young rat lens. Science 197, 1010-12.
63. Taratuta, V. G., Holschbach, A., Thurston, G. M., Blankschtein, D. and Benedek, G. B. (1990). Liquid-liquid phase separation of aqueous lysozyme solutions: effects of pH and salt identity. J. Phys. Chem. 94, 2140-4.
64. Trokel, S. (1962). The physical basis for transparency of the crystalline lens. Invest Ophthalmol. 1, 493-501.
65. von Sallmann, L. and Munoz, C. M. (1951). Further efforts to influence X-ray cataract by chemical agents. Trans. Am. Ophthalmol. Soc. 49, 391-417.
66. Vrensen, G. and Willekens, B. (1990). Biomicroscopy and scanning electron microscopy of early opacities in the aging human lens. Invest. Ophthalmol. Vis. Sci. 31, 1582-91.
67. Wang, Z., Hess, J. L. and Bunce, G. E. (1992). Deferoxamine effect on selenite-induced cataract formation in rats. Invest. Ophthalmol. Vis. Sci. 33, 2511-19.
68. Wu, G.-S., Walker, J. and Rao, N. A. (1993). Effect of deferoxamine on retinal lipid peroxidation in experimental uveitis. Invest. Ophthalmol Vis. Sci. 34, 3084-9.
69. Young, R. W. (1991). Age-Related Cataract. Oxford University Press : New York, U.S.A.