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Volumn 138, Issue 8, 1997, Pages 3195-3206

Alterations in the insulin signaling pathway induced by immortalization and H-ras transformation of brown adipocytes

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHOTRANSFERASE; RAF PROTEIN; RAS PROTEIN;

EID: 0030806281     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.8.5293     Document Type: Article
Times cited : (18)

References (42)
  • 1
    • 0025746299 scopus 로고
    • The insulin receptor: Signaling mechanism and contribution to the pathogenesis of insulin resistance
    • Haring HU 1991 The insulin receptor: signaling mechanism and contribution to the pathogenesis of insulin resistance. Diabetologia 34:848-861
    • (1991) Diabetologia , vol.34 , pp. 848-861
    • Haring, H.U.1
  • 5
    • 0026438979 scopus 로고
    • Regulation of insulin receptor substrate 1 in liver and muscle of animal models of insulin resistance
    • Saad MJ, Araki E, Miralpeix M, Rothenberg PL, White MF, Kahn CR 1992 Regulation of insulin receptor substrate 1 in liver and muscle of animal models of insulin resistance. J Clin Invest 90:1839-1849
    • (1992) J Clin Invest , vol.90 , pp. 1839-1849
    • Saad, M.J.1    Araki, E.2    Miralpeix, M.3    Rothenberg, P.L.4    White, M.F.5    Kahn, C.R.6
  • 6
    • 0027489828 scopus 로고
    • Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats
    • Saad MJ, Folli F, Kahn JA, Kahn CR 1993 Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. J Clin Invest 92:2065-2072
    • (1993) J Clin Invest , vol.92 , pp. 2065-2072
    • Saad, M.J.1    Folli, F.2    Kahn, J.A.3    Kahn, C.R.4
  • 7
    • 0028904053 scopus 로고
    • Insulin action and the insulin signaling network
    • Cheatham B, Kahn CR 1995 Insulin action and the insulin signaling network. Endocr Rev 16:117-142
    • (1995) Endocr Rev , vol.16 , pp. 117-142
    • Cheatham, B.1    Kahn, C.R.2
  • 8
    • 0027484001 scopus 로고
    • Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin resistant and insulin-deficient diabetes mellitus
    • Folli F, Saad MJA, Backer JM, Kahn CR 1993 Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin resistant and insulin-deficient diabetes mellitus. J Clin Invest 92:17871-1794
    • (1993) J Clin Invest , vol.92 , pp. 17871-21794
    • Folli, F.1    Saad, M.J.A.2    Backer, J.M.3    Kahn, C.R.4
  • 9
    • 0028964599 scopus 로고
    • Insulin and dexametasone regulate insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells
    • Saad MJ, Folli F, Kahn RC 1995 Insulin and dexametasone regulate insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells. Endocrinology 136:1579-1588
    • (1995) Endocrinology , vol.136 , pp. 1579-1588
    • Saad, M.J.1    Folli, F.2    Kahn, R.C.3
  • 10
    • 0029071293 scopus 로고
    • Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes
    • Ricort JM, Tanti JF, Van Obberghen E, Le Marchand-Brustel Y 1995 Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes. Diabetologia 38:1148-1156
    • (1995) Diabetologia , vol.38 , pp. 1148-1156
    • Ricort, J.M.1    Tanti, J.F.2    Van Obberghen, E.3    Le Marchand-Brustel, Y.4
  • 11
    • 0028791344 scopus 로고
    • Insulin resistance is mediated by a proteolytic fragment of the insulin receptor
    • Knutson VP, Donnelly PV, Balba Y, Lopez-Reyes M 1995 Insulin resistance is mediated by a proteolytic fragment of the insulin receptor. J Biol Chem 270:24972-24981
    • (1995) J Biol Chem , vol.270 , pp. 24972-24981
    • Knutson, V.P.1    Donnelly, P.V.2    Balba, Y.3    Lopez-Reyes, M.4
  • 13
    • 0028825748 scopus 로고
    • Tumor necrosis factor α-induced phosphorylation of insulin receptor substrate-1
    • Kanety H, Feinstein R, Papa MZ, Hemi R, Karasik A 1995 Tumor necrosis factor α-induced phosphorylation of insulin receptor substrate-1. J Biol Chem 270:23780-23784
    • (1995) J Biol Chem , vol.270 , pp. 23780-23784
    • Kanety, H.1    Feinstein, R.2    Papa, M.Z.3    Hemi, R.4    Karasik, A.5
  • 14
    • 0025089836 scopus 로고
    • Development of the uncoupling protein in the rat brown adipose tissue during the perinatal period
    • Porras A, Peñas M, Fernandez M, Benito M 1990 Development of the uncoupling protein in the rat brown adipose tissue during the perinatal period. Eur J Biochem 187:671-675
    • (1990) Eur J Biochem , vol.187 , pp. 671-675
    • Porras, A.1    Peñas, M.2    Fernandez, M.3    Benito, M.4
  • 15
    • 0029143609 scopus 로고
    • Differentiation of rat brown adipocytes during late foetal development: Role of insulin-like growth factor 1
    • Teruel T, Valverde AM, Alvarez A, Benito M, Lorenzo M 1995 Differentiation of rat brown adipocytes during late foetal development: role of insulin-like growth factor 1. Biochem J 310:771-776
    • (1995) Biochem J , vol.310 , pp. 771-776
    • Teruel, T.1    Valverde, A.M.2    Alvarez, A.3    Benito, M.4    Lorenzo, M.5
  • 16
    • 0029828493 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 and insulin induce adipogenic-related gene expression in foetal brown adipocyte primary cultures
    • Teruel T, Valverde AM, Benito M, Lorenzo M 1996 Insulin-like growth factor 1 and insulin induce adipogenic-related gene expression in foetal brown adipocyte primary cultures. Biochem J 319:627-632
    • (1996) Biochem J , vol.319 , pp. 627-632
    • Teruel, T.1    Valverde, A.M.2    Benito, M.3    Lorenzo, M.4
  • 17
    • 0023913992 scopus 로고
    • Hormonal regulation of foetal lipogenesis in brown adipocyte primary cultures
    • Lorenzo M, Roncero C, Fabregat I, Benito M 1988 Hormonal regulation of foetal lipogenesis in brown adipocyte primary cultures. Biochem J 251:617-620
    • (1988) Biochem J , vol.251 , pp. 617-620
    • Lorenzo, M.1    Roncero, C.2    Fabregat, I.3    Benito, M.4
  • 18
    • 0024450642 scopus 로고
    • Hormonal regulation of Malic enzyme expression in primary cultures of foetal brown adipocytes
    • Lorenzo M, Fabregat I, Benito M 1989 Hormonal regulation of Malic enzyme expression in primary cultures of foetal brown adipocytes. Biochem Biophys Res Commun 163:341-347
    • (1989) Biochem Biophys Res Commun , vol.163 , pp. 341-347
    • Lorenzo, M.1    Fabregat, I.2    Benito, M.3
  • 19
    • 0026557397 scopus 로고
    • Hormonal regulation of malic enzyme and glucose 6-phosphate dehydrogenase in fetal brown adipocyte primary cultures
    • Valverde AM, Benito M, Lorenzo M 1992 Hormonal regulation of malic enzyme and glucose 6-phosphate dehydrogenase in fetal brown adipocyte primary cultures. Eur J Biochem 203:313-319
    • (1992) Eur J Biochem , vol.203 , pp. 313-319
    • Valverde, A.M.1    Benito, M.2    Lorenzo, M.3
  • 21
    • 0030021071 scopus 로고
    • Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes and hyperlipidemia
    • Hamann A, Flier JS, Lowell BB 1995 Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes and hyperlipidemia. Endocrinology 137:22-29
    • (1995) Endocrinology , vol.137 , pp. 22-29
    • Hamann, A.1    Flier, J.S.2    Lowell, B.B.3
  • 22
    • 0027131838 scopus 로고
    • Establishment of permanent brown adipocyte cell lines by transfection with SV40 large T antigen and ras genes
    • Benito M, Porras A, Santos E 1993 Establishment of permanent brown adipocyte cell lines by transfection with SV40 large T antigen and ras genes. Exp Cell Res 209:248-254
    • (1993) Exp Cell Res , vol.209 , pp. 248-254
    • Benito, M.1    Porras, A.2    Santos, E.3
  • 23
    • 0029658616 scopus 로고    scopus 로고
    • P21-ras induced differentiation-related gene expression in fetal brown adipocyte primary cells and cell lines
    • Lorenzo M, Valverde AM, Teruel T, Alvarez A, and Benito M 1996 P21-ras induced differentiation-related gene expression in fetal brown adipocyte primary cells and cell lines. Cell Growth Differ 7:1251-1259
    • (1996) Cell Growth Differ , vol.7 , pp. 1251-1259
    • Lorenzo, M.1    Valverde, A.M.2    Teruel, T.3    Alvarez, A.4    Benito, M.5
  • 24
    • 0027763185 scopus 로고
    • IGF-1 is a mitogen also involved in differentiation-related gene expression in fetal rat brown adipocytes
    • Lorenzo M, Valverde AM, Teruel T, Benito M 1993 IGF-1 is a mitogen also involved in differentiation-related gene expression in fetal rat brown adipocytes. J Cell Biol 123:1567-1575
    • (1993) J Cell Biol , vol.123 , pp. 1567-1575
    • Lorenzo, M.1    Valverde, A.M.2    Teruel, T.3    Benito, M.4
  • 26
    • 0027193980 scopus 로고
    • Divergent regulation of phosphatidylinositol 3-kinase P85α and P85β isoforms upon T cell activation
    • Reif K, Gout I, Waterfield MD, Cantrell DA 1993 Divergent regulation of phosphatidylinositol 3-kinase P85α and P85β isoforms upon T cell activation. J Biol Chem 268:10780-10788
    • (1993) J Biol Chem , vol.268 , pp. 10780-10788
    • Reif, K.1    Gout, I.2    Waterfield, M.D.3    Cantrell, D.A.4
  • 27
    • 0027716596 scopus 로고
    • Inhibition by cAMP of Ras-dependent activation of Raf
    • Cook SJ, McCormick F 1993 Inhibition by cAMP of Ras-dependent activation of Raf. Science 262:1069-1072
    • (1993) Science , vol.262 , pp. 1069-1072
    • Cook, S.J.1    McCormick, F.2
  • 29
    • 0023625090 scopus 로고
    • Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
    • Angel P, Imagawa M, Chiu R, Stein B, Imbra R, Rahmsdord H, Jonat C, Herrlich P, Karin M 1987 Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729-739
    • (1987) Cell , vol.49 , pp. 729-739
    • Angel, P.1    Imagawa, M.2    Chiu, R.3    Stein, B.4    Imbra, R.5    Rahmsdord, H.6    Jonat, C.7    Herrlich, P.8    Karin, M.9
  • 30
    • 0028844021 scopus 로고
    • Impairment of the liver insulin receptor autoactivation cascade at full-term pregnancy in the rat
    • Martinez C, Molero JC, Ruiz P, del Arco A, Andrés A, Carrascosa JM 1995 Impairment of the liver insulin receptor autoactivation cascade at full-term pregnancy in the rat. Biochem J 311:523-529
    • (1995) Biochem J , vol.311 , pp. 523-529
    • Martinez, C.1    Molero, J.C.2    Ruiz, P.3    Del Arco, A.4    Andrés, A.5    Carrascosa, J.M.6
  • 31
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities utilizing the principle of protein dye binding
    • Bradford M 1976 A rapid and sensitive method for the quantitation of microgram quantities utilizing the principle of protein dye binding. Anal Biochem 72:248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.1
  • 32
    • 0020065416 scopus 로고
    • Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor
    • Kasuga M, Karlsson FA, Kahn CR 1982 Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. Science 215:185-187
    • (1982) Science , vol.215 , pp. 185-187
    • Kasuga, M.1    Karlsson, F.A.2    Kahn, C.R.3
  • 34
    • 0029135003 scopus 로고
    • New frontiers in insulin receptor substrate signaling
    • Myers MG Jr, White M 1995 New frontiers in insulin receptor substrate signaling. Trends Endocrinol Metab 6:209-215
    • (1995) Trends Endocrinol Metab , vol.6 , pp. 209-215
    • Myers Jr., M.G.1    White, M.2
  • 37
    • 0023605610 scopus 로고
    • Phosphorylation of purified insulin receptor by cAMP kinase
    • Roth J, Beaudoin J 1987 Phosphorylation of purified insulin receptor by cAMP kinase. Diabetes 36:123-126
    • (1987) Diabetes , vol.36 , pp. 123-126
    • Roth, J.1    Beaudoin, J.2
  • 38
    • 0023834876 scopus 로고
    • Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity
    • Takayama S, White MF, Kahn R 1988 Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. J Biol Chem 263:3440-3447
    • (1988) J Biol Chem , vol.263 , pp. 3440-3447
    • Takayama, S.1    White, M.F.2    Kahn, R.3
  • 41
    • 0029119085 scopus 로고
    • Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle
    • Dunaif A, Xia J, Book C-B, Schenker E, Tang Z 1995 Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. J Clin Invest 96:801-810
    • (1995) J Clin Invest , vol.96 , pp. 801-810
    • Dunaif, A.1    Xia, J.2    Book, C.-B.3    Schenker, E.4    Tang, Z.5
  • 42
    • 0028228521 scopus 로고
    • Insulin stimulates phosphorylation of c-Jun, c-Fos, and Fos-related proteins in cultured adipocytes
    • Kim S-J, Kahn CR 1994 Insulin stimulates phosphorylation of c-Jun, c-Fos, and Fos-related proteins in cultured adipocytes. J Biol Chem 269:11887-11892
    • (1994) J Biol Chem , vol.269 , pp. 11887-11892
    • Kim, S.-J.1    Kahn, C.R.2


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