Free fatty acids act as endogenous ionophores, resulting in Na+ and Ca2+ influx and myocyte apoptosis

Cardiovascular Research

Volumn 78, Issue 3, 2008, Pages 533-545

  Fang, Kwang Ming ^a,b   Lee, An Sheng ^a   Su, Ming Jai ^a   Lin, Chien Liang ^a   Chien, Chung Liang ^a   Wu, Mei Lin ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Apoptosis; Arachidonic acid; Mitochondrial Na+

Indexed keywords

ARACHIDONIC ACID; CALCIUM ION; CASPASE 3; FATTY ACID; LINOLEIC ACID; OLEIC ACID; PALMITIC ACID; SODIUM ION;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CONDUCTANCE; CALCIUM TRANSPORT; CONTROLLED STUDY; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; ELECTRON MICROSCOPY; FEMALE; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART VENTRICLE WALL; LIPID METABOLISM; MALE; MITOCHONDRIAL MEMBRANE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SODIUM CONDUCTANCE; SODIUM TRANSPORT; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ARACHIDONIC ACID; CALCIUM; CASPASE 3; CYTOCHROMES C; CYTOSOL; FATTY ACIDS, NONESTERIFIED; FEMALE; GUINEA PIGS; IONOPHORES; LINOLEIC ACID; MALE; MEMBRANE POTENTIALS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL SWELLING; MYOCYTES, CARDIAC; OLEIC ACID; PALMITIC ACID; PATCH-CLAMP TECHNIQUES; SODIUM; TIME FACTORS;

EID: 44449105986     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvn030     Document Type: Article

References (41)

1. van Bilsen M, van der Vusse GJ, Willemsen PHM, Coumans WA, Roemen THM, Reneman RS. Lipid alterations in isolated working rat hearts during ischemia and reperfusion: its relation to myocardial damage. Circ Res 1989;64:304-314.
2. van der Vusse GJ, Glatz JFC, Stam HCG, Reneman RS. Fatty acid homeostasis in the normoxic and ischemic heart. Physiol Rev 1992;72:881-940.
3. Vork MM, Glatz JFC, van der Vusse GJ. Release of fatty acid-binding protein and long chain fatty acids from isolated rat heart after ischemia and subsequent calcium paradox. Mol Cell Biol 1993;123:175-184.
4. Meves H. Modulation of ion channels by arachidonic acid. Prog Neurobiol 1994;43:175-186.
5. Mamas MA, Terrar DA. Actions of arachidonic acid on contractions and associated electrical activity in guinea-pig isolated ventricular myocytes. Exp Physiol 2001;86:437-449.
6. 2+-dependent apoptosis through the mitochondrial pathway. J Biol Chem 2004;279:25219-25225.
7. van der Vusse GJ, Cornelussen RN, Roemen TH, Snoeckx LH. Heat stress pretreatment mitigates postischemic arachidonic acid accumulation in rat heart. Mol Cell Biochem 1998;185:205-211.
8. Cocco T, Di Paola M, Papa S, Lorusso M. Arachidonic acid interaction with the mitochondrial electron transport chain promotes reactive oxygen species generation. Free Rad Biol Medicine 1999;27:51-59.
9. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J 1999;341:233-249.
10. Petronilli V, Penzo D, Scorrano L, Bernardi P, Di Lisa F. The mitochondrial permeability transition, release of cytochrome c and cell death. J Biol Chem 2001;276:12030-12034.
11. + and is a causative event in the death of myocytes in post-ischemic reperfusion of the heart. J Biol Chem 2001;276:2571- 2575.
12. Halestrap AP. A pore way to die. Nature 2005;434:578-579.
13. Duchen MR, McGuinness O, Brown LA, Crompton M. On the involvement of a cyclosporin-A sensitive mitochondrial pore in myocardial reperfusion injury. Cardiovasc Res 1993;27:1790-1794.
14. Suleiman M-S, Halestrap AP, Griffiths EJ. Mitochondria: a target for myocardial protection. Pharmacol Therapt 2001;89:29-46.
15. 2+ channel alpha1 G. J Gen Physiol 2004;124:225-238.
16. 2+ entry channel. J Biol Chem 2000;275:9114-9119.
17. 2+ (ARC) channels. J Biol Chem 2003;278:10174-10181.
18. Su M-J, Chang G-J, Wu M-H, Kuo S-C. Electrophysiological basis for the antiarrhythmic action and positive inotropy of HA-7, a furoquinoline alkaloid derivative, in rat heart. Br J Pharmacol 1997;122:1285-1298.
19. 2+ transients during the contractile cycle in adult rabbit cardiac myocytes. Biochem Biophys Res Commun 1997;236:738-742.
20. 2+ signals. J Biol Chem 2001;276:26411-26420.
21. 2+ uptake into mitochondria in vitro and in situ in single cardiac myocytes. J Biol Chem 1998;273:10223-10231.
22. Gincel D, Zaid H, Shoshan-Barmatz V. Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function. Biochem J 2001;358:147-155.
23. Rizzuto R, Bernardi P, Pozzan T. Mitochondria as all-round players of the calcium game. J Physiol (London) 2000;529:37-47.
24. 2+ exchange. Trends Pharmacol Sci 1993;14:408-413.
25. Griffiths EJ, Halestrap AP. Mitochondrial non-specific pores remain closed during cardiac ischemia, but open upon reperfusion. Biochem J 1995;307:93-98.
26. Gunter TE, Buntinas L, Sparagna G, Eliseev R, Gunter K. Mitochondrial calcium transport: mechanisms and functions. Cell Calcium 2000;28:285-296.
27. 2+ exchange during metabolic inhibition in rat cardiomyocytes. FEBS Lett 1999;453:400-404.
28. Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS. Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation. J Neurochem 2002;80:531-538.
29. Takeuchi Y, Morii H, Tamura M, Hayaishi O, Watanabe Y. A possible mechanism of mitochondrial dysfunction during cerebral ischemia: inhibition of mitochondrial respiration activity by arachidonic acid. Arch Biochem Biophys 1991;289:33-38.
30. Buja LM, Entman ML. Modes of myocardial cell injury and cell death in ischemic heart disease. Circulation 1998;98:1355-1357.
31. Ohno M, Takemura G, Ohno A, Misao J, Hayakawa Y, Fujiwara H et al. 'Apoptotic' myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA fragmentation: analysis by immunogold electron microscopy combined with in situ nick end-labeling. Circulation 1998;98:1422-1430.
32. 2+ exchange. Circ Res 1989;71:547-557.
33. Piper HM, Meuter K, Schafer C. Cellular mechanism of ischemia-reperfusion injury. Ann Thorac Surg 2003;5:S644-S648.
34. 2+ loading. Circulation 1994;90:391-399.
35. 2+ overload in ischemic/reperfused hearts. Eur J Pharmacol 2004;499:179-187.
36. + current during cardiac ischemia and hypoxia. J Cardiovasc Electrophysiol 2006;17:S96-S103.
37. 2+ permeability defect. Circ Res 1981;48:711-719.
38. 2+: a control point for apoptosis. Science 2003;300:135-139.
39. Scorrano L, Penzo D, Petronilli V, Pagano F, Bernardi P. Arachidonic acid causes cell death through the mitochondrial permeability transition: implications for tumor necrosis factor-a apoptotic signaling. J Biol Chem 2001;276:12035-12040.
40. Newmeyer DD, Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell 2003;112:481-490.
41. Arends MJ, Morris RG, Wyllie AH. Apoptosis: the role of the endonuclease. Am J Pathol 1990;136:593-608.