Constitutive activity of β-adrenergic receptors in C6 glioma cells

Pharmacological Reports

Volumn 57, Issue 5, 2005, Pages 659-663

  Sokołowska, Paulina ^a   Nowak, Jerzy Z ^a,b  

^a INSTITUTE OF MEDICAL BIOLOGY   (Poland)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Alprenolol; C6 glioma cells; Constitutive receptor activtiy; Inverse agonists; Propranolol; adrenergic receptors

Indexed keywords

ALPRENOLOL; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CYCLIC AMP; ISOPRENALINE; NUCLEOTIDE; PROPRANOLOL;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN CORTEX; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; GLIOMA CELL; IC 50; MALE; NONHUMAN; PROTEIN FUNCTION; RAT; STATISTICAL SIGNIFICANCE;

EID: 33646201592     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Alewijnse AE, Smit MJ, Rodriguez-Pena MS, Verzijl D, Timmerman H, Leurs R: Modulation of forskolin-mediated adenylyl cyclase activation by constitutively active Gs-coupled receptors. FEBS Lett, 1997, 419, 171-174.
2. Benda P, Lightbody J, Sato G, Levine L, Sweet W. Differentiated rat glial cell strain in tissue culture. Science, 1968, 161, 370.
3. Chidiac P, Hebert TE, Valiquette M, Dennis M, Bouvier M: Inverse agonist activity of β-adrenergic antagonists. Mol Pharmacol, 1993, 45, 490-499.
4. Costa T, Ogino Y, Munson PJ, Onara HO, Rodbard D: Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand. Mol Pharmacol, 1992, 41, 549-560.
5. de Ligt RA, Kourounakis AP, Ijzerman AP: Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery. Br J Pharmacol, 2000, 130, 1-12.
6. Kenakin T: Efficacy as a vector: the relative prevalence and paucity of inverse agonism. Mol Pharmacol, 2004, 65, 2-11.
7. Nagaraja S, Iyer S, Liu X, Eichberg J, Bond RA: Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic beta2-adrenoceptor activation. Br J Pharmacol, 1999, 127, 1099-1104.
8. Neve KA, Barrett DA, Molinoff PB: Selective regulation of beta-1 and beta-2 adrenergic receptors by atypical agonists. J Pharmacol Exp Ther, 1985, 235, 657-664.
9. Prather P: Inverse agonists: tools to reveal ligandspecific conformations of G protein-coupled receptors. Sci STKE, 2004, 215, pel (on-line).
10. Ruck A, Millns P, Kendall DA, Hill SJ: Expression of beta2-adrenoceptors mediating cyclic AMP accumulation in astroglial and neuronal cell lines derived from the rat CNS. Biochem Pharmacol, 1990, 40, 2371-2375.
11. Salomon Y, Londos C, Rodbell M: A highly sensitive adenylate cyclase assay. Anal Biochem, 1974, 58, 541-544.
12. Shimizu H, Daly JW, Creveling CR: A radioisotopic method for measuring the formation of adenosine 3',5'- cyclic monophosphate in incubated slices of brain. J Neurochem, 1969, 16, 1609-1619.
13. Seifert R, Wenzel-Seifert K: Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors. Naunyn Schmiedebergs Arch Pharmacol, 2002, 366, 381-416.
14. Zawilska JB, Gendek-Kubiak H, Woldan-Tambor A, Wiktorowska-Owczarek A, Nowak JZ: Histamine-induced cyclic AMP formation in the chick hypothalamus: interaction with vasoactive intestinal peptide. Pharmacol Rep, 2005, 57, 188-194.