Synthesis of 1-benzothiepine and 1-benzazepine derivatives as orally active CCR5 antagonists

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 2, 2004, Pages 254-258

  Aramaki, Yoshio ^a   Seto, Masaki ^a   Okawa, Tomohiro ^a   Oda, Tsuneo ^a   Kanzaki, Naoyuki ^a   Shiraishi, Mitsuru ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

1 benzazapine; 1 benzothiepine; CCR5 antagonist; Quaternary ammonium salt; Tertiary amine moiety

Indexed keywords

1 BENZOTHIEPIN 1,1 DIOXIDE; 1 METHYL 7 (4 METHYLPHENYL) N [4 [[METHYL (TETRAHYDRO 2H PYRAN 4 YL)AMINO]METHYL]PHENYL] 2,3 DIHYDRO 1H 1 BENZAZEPINE 4 CARBOXAMIDE; 7 (4 METHYLPHENYL) N [4 [[METHYL (TETRAHYDRO 2H PYRAN 4 YL)AMINO]METHYL]PHENYL] 2,3 DIHYDRO 1 BENZOTHIEPINE 4 CARBOXAMIDE; 7 (4 METHYLPHENYL) N [4 [[METHYL (TETRAHYDRO 2H PYRAN 4 YL)AMINO]METHYL]PHENYL] 2,3 DIHYDRO 1 BENZOTHIEPINE 4 CARBOXAMIDE 1 OXIDE; BENZAZEPINE DERIVATIVE; BENZOCYCLOHEPTENE; BENZOTHIEPIN DERIVATIVE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; FUSED ALICYCLIC AROMATIC COMPOUND; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; CRICETULUS; DRUG ANTAGONISM; HAMSTER; SYNTHESIS;

ANIMALS; BENZAZEPINES; BENZOCYCLOHEPTENES; BENZOTHIEPINS; CHO CELLS; CRICETINAE; CRICETULUS; MOLECULAR STRUCTURE; RECEPTORS, CCR5;

EID: 4444384251     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.52.254     Document Type: Article

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8. The further details of experimental conditions and data are not shown.