Characterization of thiol-conjngated metabolites of 2-propylpent-4-enoic acid (4-ene VPA), a toxic metabolite of valproic acid, by electrospray tandem mass spectrometry

Journal of Mass Spectrometry

Volumn 31, Issue 8, 1996, Pages 926-936

  Tang, Wei ^a   Abbott, Frank S ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Bioactivation; Liquid chromatography tandem mass spectrometry; Metabolic profiling; Toxins; Valproic acid

Indexed keywords

2 PROPYL 4 PENTENOIC ACID; DRUG METABOLITE; VALPROIC ACID; 2-PROPYL-4-PENTENOIC ACID; ANTICONVULSIVE AGENT; MONOUNSATURATED FATTY ACID; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVATION; DRUG BILE LEVEL; DRUG METABOLISM; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; LIQUID CHROMATOGRAPHY; LIVER TOXICITY; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; ANIMAL; BILE; BIOTRANSFORMATION; CHEMISTRY; LIVER; MASS SPECTROMETRY; ONLINE SYSTEM; SPRAGUE DAWLEY RAT; SYNTHESIS;

ANIMALS; ANTICONVULSANTS; BILE; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; FATTY ACIDS, MONOUNSATURATED; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; ONLINE SYSTEMS; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL COMPOUNDS; VALPROIC ACID;

EID: 0029664922     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9888(199608)31:8<926::AID-JMS383>3.0.CO;2-P     Document Type: Article

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