Folate and cobalamin synergistically decrease the risk of high plasma homocysteine in a nonsupplemented elderly institutionalized population

Clinical Biochemistry

Volumn 37, Issue 10, 2004, Pages 904-910

  Huerta, José M ^a   González, Sonia ^a   Vigil, Elena ^b   Prada, Mercedes ^b   San Martín, Julia ^b   Fernández, Serafina ^a   Patterson, Ángeles M ^a   Lasheras, Cristina ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

Author keywords

Cobalamin; Elderly; Folate; Homocysteine; Hyperhomocysteinemia; Spain

Indexed keywords

COBALAMIN; FOLIC ACID; HOMOCYSTEINE;

AGED; AGING; ARTICLE; BLOOD LEVEL; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUESTIONNAIRE; RISK ASSESSMENT; RISK REDUCTION;

AGED; AGED, 80 AND OVER; CROSS-SECTIONAL STUDIES; DIET; DRUG SYNERGISM; FEMALE; FOLIC ACID; HOMES FOR THE AGED; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; MIDDLE AGED; NUTRITIONAL STATUS; RISK FACTORS; VITAMIN B 12; VITAMIN B COMPLEX;

EID: 4444355689     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2004.06.012     Document Type: Article

References (33)

1. C.J. Boushey, S.A. Beresford, G.S. Omenn, and A.G. Motulsky A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes JAMA 274 1995 1049 1057
2. I.M. Graham, L.E. Daly, and H.M. Refsum Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project JAMA 277 1997 1775 1781
3. I.A. Brouwer, M. vanDusseldorp, and C.M. Thomas Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial Am. J. Clin. Nutr. 69 1999 99 104
4. A.R. Folsom, F.J. Nieto, and P.G. McGovern Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the atherosclerosis risk in communities (ARIC) study Circulation 98 1998 204 210
5. J.W. Eikelboom, E. Lonn, J. Genest Jr., G. Hankey, and S. Yusuf Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence Ann. Intern. Med. 131 1999 363 375
6. The Homocysteine Studies Collaboration Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis JAMA 288 2002 2015 2022
7. H.J. Blom Determinants of plasma homocysteine Am. J. Clin. Nutr. 67 1998 188 189
8. P.F. Jacques, A.G. Bostom, P.W. Wilson, S. Rich, I.H. Rosenberg, and J. Selhub Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort Am. J. Clin. Nutr. 73 2001 613 621
9. O. Nygard, H. Refsum, P.M. Ueland, and S.E. Vollset Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study Am. J. Clin. Nutr. 67 1998 263 270
10. G. Varela-Moreiras Nutritional regulation of homocysteine: effects of drugs Biomed. Pharmacother. 55 2001 448 453
11. J. Selhub, P.F. Jacques, and I.H. Rosenberg Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991â€"1994): population reference ranges and contribution of vitamin status to high serum concentrations Ann. Intern. Med. 131 1999 331 339
12. A. Chait, M.R. Malinow, and D.N. Nevin Increased dietary micronutrients decrease serum homocysteine concentrations in patients at high risk of cardiovascular disease Am. J. Clin. Nutr. 70 1999 881 887
13. A. García, A. Paris-Pombo, L. Evans, A. Day, and M. Freedman Is low-dose oral cobalamin enough to normalize cobalamin function in older people? J. Am. Geriatr. Soc. 50 2002 1401 1404
14. R.Z. Stolzenberg-Solomon, E.R. Miller III, M.G. Maguire, J. Selhub, and L.J. Appel Association of dietary protein intake and coffee consumption with serum homocysteine concentrations in an older population Am. J. Clin. Nutr. 69 1999 467 475
15. C. Lasheras, J.M. Huerta, S. González, A.F. Braña, A.M. Patterson, and S. Fernández Independent and interactive association of blood antioxidants and oxidative damage in elderly people Free Radic. Res. 36 2002 875 882
16. J. Selhub, P.F. Jacques, P.W. Wilson, D. Rush, and I.H. Rosenberg Vitamin status and intake as primary determinants of homocysteinemia in an elderly population JAMA 270 1993 2693 2698
17. 12 deficiency in the elderly Annu. Rev. Nutr. 19 1999 357 377
18. W. Herrmann, H. Schorr, and M. Bodis Role of homocysteine, cystathionine and methylmalonic acid measurement for diagnosis of vitamin deficiency in high-aged subjects Eur. J. Clin. Invest. 30 2000 1083 1089
19. J. Selhub Homocysteine metabolism Annu. Rev. Nutr. 19 1999 217 246
20. W. Herrmann The importance of hyperhomocysteinemia as a risk factor for diseases: an overview Clin. Chem. Lab. Med. 39 2001 666 674
21. W. CSIC Tablas de Composición de Alimentos Instituto de Nutrición (Universidad Complutense) 1994 CSIC Madrid
22. A. Araki, and Y. Sako Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection J. Chromatogr. 422 1987 43 52
23. B.L. Kasiske, and W.F. Keane Laboratory assessment of renal disease: clearance, urinalysis, and renal biopsy B.M. Brenner F.C. Rector Jr. The kidney 1996 WB Saunders Philadelphia 1137 1173
24. 12, pantothenic acid, biotin, and choline 1998 National Academy Press Washington (DC)
25. 12 & C dietary intake of an elderly institutionalized population in León, Spain Nutr. Hosp. 18 2003 222 225
26. R.M. Ortega, R. Redondo, P. Andrés, and I. Eguileor Nutritional assessment of folate and cyanocobalamin status in a Spanish elderly group Int. J. Vitamin Nutr. Res. 63 1993 17 21
27. L.B. Rasmussen, L. Ovesen, I. Bulow, N. Knudsen, P. Laurberg, and H. Perrild Folate intake, lifestyle factors, and homocysteine concentrations in younger and older women Am. J. Clin. Nutr. 72 2000 1156 1163
28. J.B. Ubbink, P.J. Becker, W.J. Vermaak, and R. Delport Results of B-vitamin supplementation study used in a prediction model to define a reference range for plasma homocysteine Clin. Chem. 41 1995 1033 1037
29. E. Riboli, H. Ronnholm, and R. Saracci Biological markers of diet Cancer Surv. 6 1987 685 718
30. D.S. Wald, L. Bishop, and N.J. Wald Randomized trial of folic acid supplementation and serum homocysteine levels Arch. Intern. Med. 161 2001 695 700
31. National Research Council Recommended Dietary Allowances tenth ed. 1989 National Academy Press Washington (DC)
32. J. Selhub, and I.H. Rosenberg Folic Acid E.F. Ziegler L.J. Filer Present knowledge in nutrition seventh ed. 1996 ILSI Press Washington (DC) 206 219
33. V. Herbert Folic acid M.E. Shils J.A. Olson Modern nutrition in health and disease ninth ed. 1999 Williams & Wilkins Baltimore 443 446