Inducible cAMP Early Repressor Regulates Corticosterone Suppression after Tricyclic Antidepressant Treatment

Journal of Neuroscience

Volumn 24, Issue 8, 2004, Pages 1967-1975

  Conti, Alana C ^a   Kuo, Yuo Chen ^a   Valentino, Rita J ^a   Blendy, Julie A ^a,b,c  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c NONE   (United States)

Author keywords

Antidepressant; Corticosterone; Corticotropin releasing factor; CREM; CRH; Desipramine; Forced swim test; ICER; Real time quantitative PCR; Stress; Tail suspension test

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DESIPRAMINE; MESSENGER RNA; TRANSCRIPTION FACTOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE RELEASE; DRUG EFFECT; DRUG MECHANISM; FORCED SWIMMING TEST; GENE CONTROL; GENE EXPRESSION; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INDUCIBLE CYCLIC AMP EARLY REPRESSOR GENE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTITATIVE REAL TIME POLYMERASE CHAIN REACTION; REAL TIME POLYMERASE CHAIN REACTION; REPRESSOR GENE; SEIZURE; STRESS; TAIL SUSPENSION TEST; THALAMUS MIDLINE NUCLEUS;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BEHAVIOR, ANIMAL; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; CYCLIC AMP RESPONSE ELEMENT MODULATOR; DESIPRAMINE; DNA-BINDING PROTEINS; GENE EXPRESSION; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; NEURONS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PITUITARY-ADRENAL SYSTEM; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STRESS;

EID: 1442300142     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4804-03.2004     Document Type: Article

References (51)

1. Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB (1999) The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol 160:1-12.
2. Asnis GM, Sanderson WC, van Praag HM (1992) Cortisol response to intramuscular desipramine in patients with major depression and normal control subjects: a replication study. Psychiatry Res 44:237-250.
3. Blendy JA, Kaestner KH, Weinbauer GF, Nieschlag E, Schutz G (1996) Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature 380:162-165.
4. Brady LS, Whitfield Jr HJ, Fox RJ, Gold PW, Herkenham M (1991) Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications. J Clin Invest 87:831-837.
5. Centeno VA, Volosin M (1997) Chronic treatment with desipramine: effect on endocrine and behavioral responses induced by inescapable stress. Physiol Behav 62:939-944.
6. Cole AJ, Abu-Shakra S, Saffen DW, Baraban JM, Worley PF (1990) Rapid rise in transcription factor mRNAs in rat brain after electroshock-induced seizures. J Neurochem 55:1920-1927.
7. Connor TJ, Kelliher P, Shen Y, Harkin A, Kelly JP, Leonard BE (2000) Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test. Pharmacol Biochem Behav 65:591-597.
8. Conti AC, Cryan JF, Dalvi A, Lucki I, Blendy JA (2002) cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs. J Neurosci 22:3262-3268.
9. Cryan JF, Markou A, Lucki I (2002) Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci 23:238-245.
10. Dahmen N, Fehr C, Reuss S, Hiemke C (1997) Stimulation of immediate early gene expression by desipramine in rat brain. Biol Psychiatry 42:317-323.
11. Della Fazia MA, Servillo G, Foulkes NS, Sassone-Corsi P (1998) Stress-induced expression of transcriptional repressor ICER in the adrenal gland. FEBS Lett 434:33-36.
12. Delmas V, Laoide BM, Masquilier D, de Groot RP, Foulkes NS, Sassone-Corsi P (1992) Alternative usage of initiation codons in mRNA encoding the cAMP-responsive-element modulator generates regulators with opposite functions. Proc Natl Acad Sci USA 89:4226-4230.
13. Dowlatshahi D, MacQueen GM, Wang JF, Young LT (1998) Increased temporal cortex CREB concentrations and antidepressant treatment in major depression. Lancet 352:1754-1755.
14. Dowlatshahi D, MacQueen GM, Wang JF, Reiach JS, Young LT (1999) G Protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death. J Neurochem 73:1121-1126.
15. Fitzgerald LR, Vaidya VA, Terwilliger RZ, Duman RS (1996a) Electroconvulsive seizure increases the expression of CREM (cyclic AMP response element modulator) and ICER (inducible cyclic AMP early repressor) in rat brain. J Neurochem 66:429-432.
16. Fitzgerald LR, Li Z, Machida CA, Fishman PH, Duman RS (1996b) Adrenergic regulation of ICER (inducible cyclic AMP early repressor) and beta1-adrenergic receptor gene expression in C6 glioma cells. J Neurochem 67:490-497.
17. Foulkes NS, Sassone-Corsi P (1992) More is better: activators and repressors from the same gene. Cell 68:411-414.
18. Foulkes NS, Borrelli E, Sassone-Corsi P (1991) CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64:739-749.
19. Foulkes NS, Mellstrom B, Benusiglio E, Sassone-Corsi P (1992) Developmental switch of CREM function during spermatogenesis: from antagonist to activator. Nature 355:80-84.
20. Gold PW, Licinio J, Wong ML, Chrousos GP (1995) Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs. Ann NY Acad Sci 771:716-729.
21. Gonzalez GA, Montminy MR (1989) Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59:675-680.
22. Heuser IJ, Schweiger U, Gotthardt U, Schmider J, Lammers CH, Dettling M, Yassouridis A, Holsboer F (1996) Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects. Am J Psychiatry 153:93-99.
23. Holsboer-Trachsler E, Hemmeter U, Hatzinger M, Seifritz E, Gerhard U, Hobi V (1994) Sleep deprivation and bright light as potential augmenters of antidepressant drug treatment-neurobiological and psychometric assessment of course. J Psychiatry Res 28:381-399.
24. Kalitchenko N, Liu Y, Kasckow J, Aguilera G (2003) Self-limitation of cAMP-stimulated CRH transcription in the hypothalamic cell line 4B: role of inducible cAMP early repressor (ICER). Soc Neurosci Abstr 29:15.11.
25. Lalli E, Sassone-Corsi P (1994) Signal transduction and gene regulation: the nuclear response to cAMP. J Biol Chem 269:17359-17362.
26. Laoide BM, Foulkes NS, Schlotter F, Sassone-Corsi P (1993) The functional versatility of CREM is determined by its modular structure. EMBO J 12:1179-1191.
27. Lee KA, Masson N (1993) Transcriptional regulation by CREB and its relatives. Biochim Biophys Acta 1174:221-233.
28. Liu Y, Shepard JD, Morales M, Sassone-Corsi P, Aguilera G (2003) Involvement of glucocorticoids and inducible isoforms of CREM in the termination of corticotropin releasing hormone transcriptional responses to stress. Soc Neurosci Abstr 29:15.10.
29. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408.
30. Lucki I (2001) A prescription to resist proscriptions for murine models of depression. Psychopharmacology (Berl) 153:395-398.
31. Lucki I, Dalvi A, Mayorga AJ (2001) Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice. Psychopharmacology (Berl) 155:315-322.
32. Luckman SM, Cox HJ (1995) Expression of inducible cAMP early repressor (ICER) in hypothalamic magnocellular neurons. Brain Res Mol Brain Res 34:231-238.
33. Maldonado R, Smadja C, Mazzucchelli C, Sassone-Corsi P, Mazucchelli C (1999) Altered emotional and locomotor responses in mice deficient in the transcription factor CREM. Proc Natl Acad Sci USA 96:14094-14099.
34. Mazzucchelli C, Sassone-Corsi P (1999) The inducible cyclic adenosine monophosphate early repressor (ICER) in the pituitary intermediate lobe: role in the stress response. Mol Cell Endocrinol 155:101-113.
35. Mellstrom B, Naranjo JR, Foulkes NS, Lafarga M, Sassone-Corsi P (1993) Transcriptional response to cAMP in brain: specific distribution and induction of CREM antagonists. Neuron 10:655-665.
36. Meyer TE, Waeber G, Lin J, Beckmann W, Habener JF (1993) The promoter of the gene encoding 3′,5′-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription. Endocrinology 132:770-780.
37. Molina CA, Foulkes NS, Lalli E, Sassone-Corsi P (1993) Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Cell 75:875-886.
38. Nantel F, Monaco L, Foulkes NS, Masquilier D, LeMeur M, Henriksen K, Dierich A, Parvinen M, Sassone-Corsi P (1996) Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature 380:159-162.
39. Nibuya M, Nestler EJ, Duman RS (1996) Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci 16:2365-2372.
40. O'Brien D, Skelton KH, Owens MJ, Nemeroff CB (2001) Are CRF receptor antagonists potential antidepressants? Hum Psychopharmacol 16:81-87.
41. Porsolt RD, Le Pichon M, Jalfre M (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266:730-732.
42. Sapolsky RM (2000) Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 57:925-935.
43. Silva AJ, Simpson EM, Takahashi JS, Lipp H-P, Nakanishi S, Wehner JM, Giese KP, Tully T, Abel T, Chapman PF, Fox K, Grant S, Itohara S, Lathe R, Mayford M, McNamara JO, Morris RJ, Picciotto M, Roder J, Shin H-S, Slessinger PA, Storm DR, Stryker MP, Tonegawa S, Wang Y, Wolfer DP (1997) Mutant mice and neuroscience: Recommendations concerning genetic background. Neuron 19:755-759.
44. Stehle JH, Foulkes NS, Molina CA, Simonneaux V, Pevet P, Sassone-Corsi P (1993) Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland. Nature 365:314-320.
45. Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85:367-370.
46. Sunal R, Gumusel B, Kayaalp SO (1994) Effect of changes in swimming area on results of "behavioral despair test". Pharmacol Biochem Behav 49:891-896.
47. Tamura T, Sumita K, Fujino I, Aoyama A, Horikoshi M, Hoffmann A, Roeder RG, Muramatsu M, Mikoshiba K (1991) Striking homology of the "variable" N-terminal as well as the "conserved core" domains of the mouse and human TATA-factors (TFIID). Nucleic Acids Res 19:3861-3865.
48. Thome J, Sakai N, Shin K, Steffen C, Zhang YJ, Impey S, Storm D, Duman RS (2000) cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment. J Neurosci 20:4030-4036.
49. Valentino RJ, Page M, Van Bockstaele E, Aston-Jones G (1992) Corticotropin-releasing factor innervation of the locus coeruleus region: distribution of fibers and sources of input. Neuroscience 48:689-705.
50. Van Bockstaele EJ, Colago EE, Valentino RJ (1996) Corticotropin-releasing factor-containing axon terminals synapse onto catecholamine dendrites and may presynaptically modulate other afferents in the rostral pole of the nucleus locus coeruleus in the rat brain. J Comp Neurol 364:523-534.
51. Wilson PA, Melton DA (1994) Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr Biol 4:676-686.