The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) provokes a prolonged morphologic response and ERK activation in Tsc2-null renal tumor cells

Toxicological Sciences

Volumn 81, Issue 1, 2004, Pages 233-242

  Kolb, Todd M ^b   Davis, Myrtle A ^a  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Protein kinase C; TPA; Tsc2

Indexed keywords

BISINDOLYLMALEIMIDE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; RAP PROTEIN; TUBERIN; TUMOR PROMOTER; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL DEATH; CELL INTERACTION; CELL PROLIFERATION; CELL STRUCTURE; CELL TYPE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; KIDNEY TUMOR; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TUMOR CELL; TUMOR PROMOTION;

ANIMALS; APOPTOSIS; CARCINOGENS; CARCINOMA, RENAL CELL; CELL DEATH; CELL DIVISION; CELL LINE, TUMOR; ENZYME ACTIVATION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLASMIDS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; RATS; REPRESSOR PROTEINS; TELOMERE-BINDING PROTEINS; TETRADECANOYLPHORBOL ACETATE; TUMOR SUPPRESSOR PROTEINS;

EID: 4444292225     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh183     Document Type: Article

References (34)

1. Astrinidis, A., Cash, T. P., Hunter, D. S., Walker, C. L., Chernoff, J., and Henske, E. P. (2002). Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene 21, 8470-8476.
2. Blumberg, P., Acs, P., Bhattacharyya, D., and Lorenzo, P. (2000). Inhibitors of protein kinase C and related receptors for the lipophilic second messenger sn- 1,2-diacylglycerol. In Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases (J. S. Gutkind, Ed.), pp. 347-364. Humana Press, Totowa, NJ.
3. Chao, T. S., Foster, D. A., Rapp, U. R., and Rosner, M. R. (1994). Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium. J. Biol. Chem. 269, 7337-7341.
4. Engers, R., Mrzyk, S., Springer, E., Fabbro, D., Weissgerber, G., Gernharz, C. D., and Gabbert, H. E. (2000). Protein kinase C in human renal cell carcinomas: Role in invasion and differential isoenzyme expression. Br. J. Cancer 82, 1063-1069.
5. Everitt, J. I., Goldsworthy, T. L., Wolf, D. C., and Walker, C. L. (1992). Hereditary renal cell carcinoma in the Eker rat: A rodent familial cancer syndrome. J. Urol. 148, 1932-1936.
6. Franke, B., Akkerman, J. W., and Bos, J. L. (1997). Rapid Ca2+-mediated activation of Rap1 in human platelets. Embo J. 16, 252-259.
7. Freed, J. J., Howard, S., Lerro, A., Dodson, L., Scsok, D., and Knudson, A. G. (1990). Hereditary renal tumors in the rat: Cell lines from adenocarcinomas induced by the Eker mutation. Proc. Am. Assoc. Cancer Res. 31, 317.
8. Gao, X., and Pan, D. (2001). TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev. 15, 1383-1392.
9. Goncharova,E.A.,Goncharov,D.A.,Eszterhas,A.,Hunter,D.S.,Glassberg,M.K., Yeung, R. S., Walker, C. L., Noonan, D., Kwiatkowski, D. J., Chou, M. M., Panettieri, R. A., Jr., and Krymskaya, V. P. (2002). Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J. Biol. Chem. 277, 30958-30967.
10. Gottlicher, M. (1999). Receptor toxicology. In Toxicology (H. Marquardt, S. Schafer, R. McClellan, and R. Welsch, Eds.), pp. 231-243. Academic Press, San Diego, CA.
11. Hall, A. (2000). GTPases. In Frontiers in Molecular Biology (B. Hames and D. Glover, Eds.), pp. 67-175. Oxford University Press, New York.
12. Herrmann, C., Horn, G., Spaargaren, M., and Wittinghofer, A. (1996). Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor. J. Biol. Chem. 271, 6794-6800.
13. Hyatt, S. L., Liao, L., Chapline, C., and Jaken, S. (1994). Identification and characterization of alpha-protein kinase C binding proteins in normal and transformed REF52 cells. Biochemistry 33, 1223-1228.
14. Imamura, H., Takaishi, K., Nakano, K., Kodama, A., Oishi, H., Shiozaki, H., Monden, M., Sasaki, T., and Takai, Y. (1998). Rho and Rab small G proteins coordinately reorganize stress fibers and focal adhesions in MDCK cells. Mol. Biol. Cell 9, 2561-2575.
15. Inoki, K., Li, Y., Zhu, T., Wu, J., and Guan, K. L. (2002). TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4, 648-657.
16. Jaken, S., Leach, K., and Klauck, T. (1989). Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts. J Cell. Biol. 109, 697-704.
17. Kenerson, H. L., Aicher, L. D., True, L. D., and Yeung, R. S. (2002). Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res. 62, 5645-5650.
18. Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischak, H., Finkenzeller, G., Marme, D., and Rapp, U. R. (1993). Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature 364, 249-252.
19. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
20. Lamb, R. F., Roy, C., Diefenbach, T. J., Vinters, H. V., Johnson, M. W., Jay, D. G., and Hall, A. (2000). The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat. Cell Biol. 2, 281-287.
21. Lee, H. W., Smith, L., Pettit, G. R., Vinitsky, A., and Smith, J. B. (1996). Ubiquitination of protein kinase C-alpha and degradation by the proteasome. J. Biol. Chem. 271, 20973-20976.
22. Momose, S., Kobayashi, T., Mitani, H., Hirabayashi, M., Ito, K., Ueda, M., Nabeshima, Y., and Hino, O. (2002). Identification of the coding sequences responsible for Tsc2-mediated tumor suppression using a transgenic rat system. Hum. Mol. Genet. 11, 2997-3006.
23. M'Rabet, L., Coffer, P., Zwartkruis, F., Franke, B., Segal, A. W., Koenderman, L., and Bos, J. L. (1998). Activation of the small GTPase rap1 in human neutrophils. Blood 92, 2133-2140.
24. Nakashima, S. (2002). Protein kinase calpha (PKCalpha): Regulation and biological function. J. Biochem. (Tokyo) 132, 669-675.
25. Ng, T., Parsons, M., Hughes, W. E., Monypenny, J., Zicha, D., Gautreau, A., Arpin, M., Gschmeissner, S., Verveer, P. J., Bastiaens, P. I., and Parker, P. J. (2001). Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility. Embo J. 20, 2723-2741.
26. Rahilly, M. A., and Fleming, S. (1992). A tumour promoter induces alterations in vinculin and actin distribution in human renal epithelium. J. Pathol. 166, 283-288.
27. Tee, A. R., Fingar, D. C., Manning, B. D., Kwiatkowski, D. J., Cantley, L. C., and Blenis, J. (2002). Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)mediated downstream signaling. Proc. Natl. Acad. Sci. U.S.A. 99, 13571-13576.
28. Toullec, D., Pianetti, P., Coste, H., Bellevergue, P., Grand-Perret, T., Ajakane, M., Baudet, V., Boissin, P., Boursier, E., Loriolle, F., Duhamel, L., Charon, D., and Kirilovsky, J. (1991). The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266, 15771-15781.
29. Wienecke, R., Konig, A., and DeClue, J. E. (1995). Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity. J. Biol. Chem. 270, 16409-16414.
30. Wilkinson, S. E., Parker, P. J., and Nixon, J. S. (1993). Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem. J. 294, 335-337.
31. Xiao, G. H., Shoarinejad, F., Jin, F., Golemis, E. A., and Yeung, R. S. (1997). The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis. J. Biol. Chem. 272, 6097-6100.
32. York, R. D., Yao, H., Dillon, T., Ellig, C. L., Eckert, S. P., McCleskey, E. W., and Stork, P. J. (1998). Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392, 622-626.
33. Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., and Pan, D. (2003). Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol. 5, 578-581.
34. Zwartkruis, F. J., Wolthuis, R. M., Nabben, N. M., Franke, B., and Bos, J. L. (1998). Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling. Embo J. 17, 5905-5912.