-
1
-
-
18344410191
-
Blockade of IL-6 transsignaling abrogates established experimental colitis in mice by suppression of the antiapoptotic resistance of lamina propria T cells
-
Atreya R., Mudter J., Finotto S., Müllberg J., Jostock T., Wirtz S., Schütz M., Bartsch B., Holtmann M., Becker C., Strand D., Czaja J., Schlaak J.F., Lehr H.A., Autschbach F., Schürmann G., Nishimoto N., Yoshizaki K., Ito H., Kishimoto T., Galle P.R., Rose-John S., Neurath M.F. Blockade of IL-6 transsignaling abrogates established experimental colitis in mice by suppression of the antiapoptotic resistance of lamina propria T cells. Nat. Med. 6:2000;583
-
(2000)
Nat. Med.
, vol.6
, pp. 583
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
Müllberg, J.4
Jostock, T.5
Wirtz, S.6
Schütz, M.7
Bartsch, B.8
Holtmann, M.9
Becker, C.10
Strand, D.11
Czaja, J.12
Schlaak, J.F.13
Lehr, H.A.14
Autschbach, F.15
Schürmann, G.16
Nishimoto, N.17
Yoshizaki, K.18
Ito, H.19
Kishimoto, T.20
Galle, P.R.21
Rose-John, S.22
Neurath, M.F.23
more..
-
2
-
-
0027296376
-
Suramin inhibits the stimulation of acute phase plasma protein genes by IL-6-type cytokines in rat hepatoma cells
-
Baumann H., Strassmann G. Suramin inhibits the stimulation of acute phase plasma protein genes by IL-6-type cytokines in rat hepatoma cells. J. Immunol. 151:1993;1456
-
(1993)
J. Immunol.
, vol.151
, pp. 1456
-
-
Baumann, H.1
Strassmann, G.2
-
3
-
-
0028013066
-
Brief report: Alleviation of systemic manifestations of Castleman's disease by monoclonal anti-interleukin-6 antibody
-
Beck J.T., Hsu S.M., Wijdenes J., Bataille R., Klein B., Vesole D., Hayden K., Jagannath S., Barlogie B. Brief report: alleviation of systemic manifestations of Castleman's disease by monoclonal anti-interleukin-6 antibody. N. Engl. J. Med. 330:1994;602
-
(1994)
N. Engl. J. Med.
, vol.330
, pp. 602
-
-
Beck, J.T.1
Hsu, S.M.2
Wijdenes, J.3
Bataille, R.4
Klein, B.5
Vesole, D.6
Hayden, K.7
Jagannath, S.8
Barlogie, B.9
-
4
-
-
0025076369
-
Structure-function analysis of human IL-6. Epitope mapping of neutralizing monoclonal antibodies with amino- and carboxyl-terminal deletion mutants
-
Brakenhoff J.P., Hart M., De Groot E.R., Di Padova F., Aarden L.A. Structure-function analysis of human IL-6. Epitope mapping of neutralizing monoclonal antibodies with amino- and carboxyl-terminal deletion mutants. J. Immunol. 145:1990;561
-
(1990)
J. Immunol.
, vol.145
, pp. 561
-
-
Brakenhoff, J.P.1
Hart, M.2
De Groot, E.R.3
Di Padova, F.4
Aarden, L.A.5
-
5
-
-
0036899812
-
Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial
-
Choy E.H., Isenberg D.A., Garrood T., Farrow S., Ioannou Y., Bird H., Cheung N., Williams B., Hazleman B., Price R., Yoshizaki K., Nishimoto N., Kishimoto T., Panayi G.S. Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum. 46:2002;3143
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 3143
-
-
Choy, E.H.1
Isenberg, D.A.2
Garrood, T.3
Farrow, S.4
Ioannou, Y.5
Bird, H.6
Cheung, N.7
Williams, B.8
Hazleman, B.9
Price, R.10
Yoshizaki, K.11
Nishimoto, N.12
Kishimoto, T.13
Panayi, G.S.14
-
6
-
-
0030760235
-
Concentrations and origins of soluble interleukin-6 receptor-alpha in serum and synovial fluid
-
Desgeorges A., Gabay C., Silacci P., Novick D., Roux-Lombard P., Grau G., Dayer J.M., Vischer T., Guerne P.A. Concentrations and origins of soluble interleukin-6 receptor-alpha in serum and synovial fluid. J. Rheumatol. 24:1997;1510
-
(1997)
J. Rheumatol.
, vol.24
, pp. 1510
-
-
Desgeorges, A.1
Gabay, C.2
Silacci, P.3
Novick, D.4
Roux-Lombard, P.5
Grau, G.6
Dayer, J.M.7
Vischer, T.8
Guerne, P.A.9
-
7
-
-
0037082158
-
High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells
-
Durocher Y., Perret S., Kamen A. High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells. Nucleic Acids Res. 30:2002;2002
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 2002
-
-
Durocher, Y.1
Perret, S.2
Kamen, A.3
-
8
-
-
0030614539
-
A designer cytokine with high activity on human hematopoietic progenitor cells
-
Fischer M., Goldschmitt J., Peschel C., Kallen K.J., Brakenhoff J.P.J., Wollmer A., Grötzinger J., Rose-John S. A designer cytokine with high activity on human hematopoietic progenitor cells. Nat. Biotechnol. 15:1997;142
-
(1997)
Nat. Biotechnol.
, vol.15
, pp. 142
-
-
Fischer, M.1
Goldschmitt, J.2
Peschel, C.3
Kallen, K.J.4
Brakenhoff, J.P.J.5
Wollmer, A.6
Grötzinger, J.7
Rose-John, S.8
-
9
-
-
0037987019
-
The family of the IL-6-type cytokines: Specificity and promiscuity of the receptor complexes
-
Grötzinger J., Kurapkat G., Wollmer A., Kalai M., Rose-John S. The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes. Prot. Struct. Funct. Genet. 27:1997;96
-
(1997)
Prot. Struct. Funct. Genet.
, vol.27
, pp. 96
-
-
Grötzinger, J.1
Kurapkat, G.2
Wollmer, A.3
Kalai, M.4
Rose-John, S.5
-
10
-
-
0041677606
-
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
-
Heinrich P.C., Behrmann I., Haan S., Hermanns H.M., Muller-Newen G., Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 374:2003;1
-
(2003)
Biochem. J.
, vol.374
, pp. 1
-
-
Heinrich, P.C.1
Behrmann, I.2
Haan, S.3
Hermanns, H.M.4
Muller-Newen, G.5
Schaper, F.6
-
11
-
-
0001640974
-
Human herpesvirus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells
-
Hoischen S.H., Vollmer P., März P., Özbek S., Götze K., Jostock T., Geib T., Müllberg J., Mechtersheimer S., Fischer M., Grötzinger J., Galle P.R., Rose-John S. Human herpesvirus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells. Eur. J. Biochem. 267:2000;3604
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 3604
-
-
Hoischen, S.H.1
Vollmer, P.2
März, P.3
Özbek, S.4
Götze, K.5
Jostock, T.6
Geib, T.7
Müllberg, J.8
Mechtersheimer, S.9
Fischer, M.10
Grötzinger, J.11
Galle, P.R.12
Rose-John, S.13
-
12
-
-
0034960582
-
Control of leukocyte infiltration during inflammation: IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment
-
Hurst S.M., Wilkinson T.S., McLoughlin R.M., Jones S., Horiuchi S., Yamamoto N., Rose-John S., Fuller G.M., Topley N., Jones S.A. Control of leukocyte infiltration during inflammation: IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment. Immunity. 14:2001;705
-
(2001)
Immunity
, vol.14
, pp. 705
-
-
Hurst, S.M.1
Wilkinson, T.S.2
McLoughlin, R.M.3
Jones, S.4
Horiuchi, S.5
Yamamoto, N.6
Rose-John, S.7
Fuller, G.M.8
Topley, N.9
Jones, S.A.10
-
13
-
-
0031856408
-
IL-6 functions in cynomolgus monkeys blocked by a humanized antibody to human IL-6 receptor
-
Imazeki I., Saito H., Hasegawa M., Shinkura H., Kishimoto T., Ohsugi Y. IL-6 functions in cynomolgus monkeys blocked by a humanized antibody to human IL-6 receptor. Int. J. Immunopharmacol. 20:1998;345
-
(1998)
Int. J. Immunopharmacol.
, vol.20
, pp. 345
-
-
Imazeki, I.1
Saito, H.2
Hasegawa, M.3
Shinkura, H.4
Kishimoto, T.5
Ohsugi, Y.6
-
15
-
-
0033080801
-
C-reactive protein: A physiological activator of interleukin 6 receptor shedding
-
Jones S.A., Novick D., Horiuchi S., Yamamoto N., Szalai A.J., Fuller G.M. C-reactive protein: a physiological activator of interleukin 6 receptor shedding. J. Exp. Med. 189:1999;599
-
(1999)
J. Exp. Med.
, vol.189
, pp. 599
-
-
Jones, S.A.1
Novick, D.2
Horiuchi, S.3
Yamamoto, N.4
Szalai, A.J.5
Fuller, G.M.6
-
16
-
-
0032986036
-
Immunoadhesins of IL-6 and hyper IL-6
-
Jostock T., Blinn G., Renné C., Kallen K.-J., Rose-John S., Müllberg J. Immunoadhesins of IL-6 and hyper IL-6. J. Immunol. Methods. 223:1999;171
-
(1999)
J. Immunol. Methods
, vol.223
, pp. 171
-
-
Jostock, T.1
Blinn, G.2
Renné, C.3
Kallen, K.-J.4
Rose-John, S.5
Müllberg, J.6
-
17
-
-
0035160256
-
Soluble gp130 is the natural inhibitor of soluble IL-6R transsignaling responses
-
Jostock T., Müllberg J., Özbek S., Atreya R., Blinn G., Voltz N., Fischer M., Neurath M.F., Rose-John S. Soluble gp130 is the natural inhibitor of soluble IL-6R transsignaling responses. Eur. J. Biochem. 268:2001;160
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 160
-
-
Jostock, T.1
Müllberg, J.2
Özbek, S.3
Atreya, R.4
Blinn, G.5
Voltz, N.6
Fischer, M.7
Neurath, M.F.8
Rose-John, S.9
-
18
-
-
0037064550
-
The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases
-
Kallen K.-J. The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases. Biochem. Biophys. Acta. 1592:2002;323
-
(2002)
Biochem. Biophys. Acta
, vol.1592
, pp. 323
-
-
Kallen, K.-J.1
-
19
-
-
0032169769
-
A possible role for soluble IL-6 receptor in the pathogenesis of systemic onset juvenile chronic arthritis
-
Keul R., Heinrich P.C., Muller-Newen G., Muller K., Woo P. A possible role for soluble IL-6 receptor in the pathogenesis of systemic onset juvenile chronic arthritis. Cytokine. 10:1998;729
-
(1998)
Cytokine
, vol.10
, pp. 729
-
-
Keul, R.1
Heinrich, P.C.2
Muller-Newen, G.3
Muller, K.4
Woo, P.5
-
20
-
-
0028359668
-
Epitope analysis of human IL-6 receptor gp80 molecule with monoclonal antibodies
-
Liautard J., Gaillard J.P., Mani J.C., Montero Julian F., Duperray C., Lu Z.Y., Jourdan M., Klein B., Brailly H., Brochier J. Epitope analysis of human IL-6 receptor gp80 molecule with monoclonal antibodies. Eur. Cytokine Netw. 5:1994;293
-
(1994)
Eur. Cytokine Netw.
, vol.5
, pp. 293
-
-
Liautard, J.1
Gaillard, J.P.2
Mani, J.C.3
Montero Julian, F.4
Duperray, C.5
Lu, Z.Y.6
Jourdan, M.7
Klein, B.8
Brailly, H.9
Brochier, J.10
-
21
-
-
0026828552
-
Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
-
Lust J.A., Donovan K.A., Kline M.P., Greipp P.R., Kyle R.A., Maihle N.J. Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine. 4:1992;96
-
(1992)
Cytokine
, vol.4
, pp. 96
-
-
Lust, J.A.1
Donovan, K.A.2
Kline, M.P.3
Greipp, P.R.4
Kyle, R.A.5
Maihle, N.J.6
-
22
-
-
0026782577
-
Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins
-
Mackiewicz A., Schooltink H., Heinrich P.C., Rose-John S. Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins. J. Immunol. 149:1992;2021
-
(1992)
J. Immunol.
, vol.149
, pp. 2021
-
-
MacKiewicz, A.1
Schooltink, H.2
Heinrich, P.C.3
Rose-John, S.4
-
23
-
-
0027518860
-
Serum interleukin-6 levels in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity
-
Madhok R., Crilly A., Watson J., Capell H.A. Serum interleukin-6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity. Ann. Rheum. Dis. 52:1993;232
-
(1993)
Ann. Rheum. Dis.
, vol.52
, pp. 232
-
-
Madhok, R.1
Crilly, A.2
Watson, J.3
Capell, H.A.4
-
24
-
-
0035090840
-
Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys
-
Mihara M., Kotoh M., Nishimoto N., Oda Y., Kumagai E., Takagi N., Tsunemi K., Ohsugi Y., Kishimoto T., Yoshizaki K., Takeda Y. Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys. Clin. Immunol. 98:2001;319
-
(2001)
Clin. Immunol.
, vol.98
, pp. 319
-
-
Mihara, M.1
Kotoh, M.2
Nishimoto, N.3
Oda, Y.4
Kumagai, E.5
Takagi, N.6
Tsunemi, K.7
Ohsugi, Y.8
Kishimoto, T.9
Yoshizaki, K.10
Takeda, Y.11
-
25
-
-
0028269268
-
Immunoassay for functional human soluble interleukin-6 receptor in plasma based on ligand/receptor interactions
-
Montero Julian F.A., Liautard J., Flavetta S., Romagne F., Gaillard J.P., Brochier J., Klein B., Brailly H. Immunoassay for functional human soluble interleukin-6 receptor in plasma based on ligand/receptor interactions. J. Immunol. Methods. 169:1994;111
-
(1994)
J. Immunol. Methods
, vol.169
, pp. 111
-
-
Montero Julian, F.A.1
Liautard, J.2
Flavetta, S.3
Romagne, F.4
Gaillard, J.P.5
Brochier, J.6
Klein, B.7
Brailly, H.8
-
26
-
-
0027074343
-
Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor
-
Müllberg J., Schooltink H., Stoyan T., Heinrich P.C., Rose-John S. Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor. Biochem. Biophys. Res. Commun. 189:1992;794
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.189
, pp. 794
-
-
Müllberg, J.1
Schooltink, H.2
Stoyan, T.3
Heinrich, P.C.4
Rose-John, S.5
-
27
-
-
0342264579
-
IL-6-receptor independent stimulation of human gp130 by viral IL-6
-
Müllberg J., Geib T., Jostock T., Hoischen S.H., Vollmer P., Voltz N., Heinz D., Galle P.R., Klouche M., Rose-John S. IL-6-receptor independent stimulation of human gp130 by viral IL-6. J. Immunol. 164:2000;4672
-
(2000)
J. Immunol.
, vol.164
, pp. 4672
-
-
Müllberg, J.1
Geib, T.2
Jostock, T.3
Hoischen, S.H.4
Vollmer, P.5
Voltz, N.6
Heinz, D.7
Galle, P.R.8
Klouche, M.9
Rose-John, S.10
-
28
-
-
0034731504
-
The mechanism of heat shock activation of ERK mitogen-activated protein kinases in the interleukin 3-dependent ProB cell line BaF3
-
Ng D.C., Bogoyevitch M.A. The mechanism of heat shock activation of ERK mitogen-activated protein kinases in the interleukin 3-dependent ProB cell line BaF3. J. Biol. Chem. 275:2000;40856
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40856
-
-
Ng, D.C.1
Bogoyevitch, M.A.2
-
29
-
-
0042834261
-
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: Blockade of arthritis severity by soluble glycoprotein 130
-
Nowell M.A., Richards P.J., Horiuchi S., Yamamoto N., Rose-John S., Topley N., Williams A.S., Jones S.A. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. J. Immunol. 171:2003;3202
-
(2003)
J. Immunol.
, vol.171
, pp. 3202
-
-
Nowell, M.A.1
Richards, P.J.2
Horiuchi, S.3
Yamamoto, N.4
Rose-John, S.5
Topley, N.6
Williams, A.S.7
Jones, S.A.8
-
30
-
-
0032533949
-
Interleukin-6 and soluble interleukin-6 receptor: Direct stimulation of gp130 and hematopoiesis
-
Peters M., Müller A., Rose-John S. Interleukin-6 and soluble interleukin-6 receptor: direct stimulation of gp130 and hematopoiesis. Blood. 92:1998;3495
-
(1998)
Blood
, vol.92
, pp. 3495
-
-
Peters, M.1
Müller, A.2
Rose-John, S.3
-
31
-
-
0028226196
-
Soluble receptors for cytokines and growth factors: Generation and biological function
-
Rose-John S., Heinrich P.C. Soluble receptors for cytokines and growth factors: generation and biological function. Biochem. J. 300:1994;281
-
(1994)
Biochem. J.
, vol.300
, pp. 281
-
-
Rose-John, S.1
Heinrich, P.C.2
-
32
-
-
0027488473
-
Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo
-
Strassmann G., Fong M., Freter C.E., Windsor S., D'Alessandro F., Nordan R.P. Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo. J. Clin. Invest. 92:1993;2152
-
(1993)
J. Clin. Invest.
, vol.92
, pp. 2152
-
-
Strassmann, G.1
Fong, M.2
Freter, C.E.3
Windsor, S.4
D'Alessandro, F.5
Nordan, R.P.6
-
33
-
-
0028946686
-
Signaling mechanisms through cytokine receptors that share signal transducing receptor components
-
Taga T., Kishimoto T. Signaling mechanisms through cytokine receptors that share signal transducing receptor components. Curr. Opin. Immunol. 7:1995;17
-
(1995)
Curr. Opin. Immunol.
, vol.7
, pp. 17
-
-
Taga, T.1
Kishimoto, T.2
-
34
-
-
0024393839
-
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
-
Taga T., Hibi M., Hirata Y., Yamasaki K., Yasukawa K., Matsuda T., Hirano T., Kishimoto T. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell. 58:1989;573
-
(1989)
Cell
, vol.58
, pp. 573
-
-
Taga, T.1
Hibi, M.2
Hirata, Y.3
Yamasaki, K.4
Yasukawa, K.5
Matsuda, T.6
Hirano, T.7
Kishimoto, T.8
-
35
-
-
0032429668
-
Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis
-
Takagi M., Mihara M., Moriya Y., Nishimoto N., Yoshizaki K., Kishimoto T., Takeda Y., Ohsugi Y. Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum. 41:1998;2117
-
(1998)
Arthritis Rheum.
, vol.41
, pp. 2117
-
-
Takagi, M.1
Mihara, M.2
Moriya, Y.3
Nishimoto, N.4
Yoshizaki, K.5
Kishimoto, T.6
Takeda, Y.7
Ohsugi, Y.8
-
36
-
-
0033565363
-
A role for the immunoglobulin-like domain of the human IL-6 receptor: Intracellular protein transport and shedding
-
Vollmer P., Oppmann B., Voltz N., Fischer M., Rose-John S. A role for the immunoglobulin-like domain of the human IL-6 receptor: intracellular protein transport and shedding. Eur. J. Biochem. 263:1999;438
-
(1999)
Eur. J. Biochem.
, vol.263
, pp. 438
-
-
Vollmer, P.1
Oppmann, B.2
Voltz, N.3
Fischer, M.4
Rose-John, S.5
-
37
-
-
0027402917
-
Treatment of severe rheumatoid arthritis by anti-interleukin-6 monoclonal antibody
-
Wendling D., Racadot E., Wijdenes J. Treatment of severe rheumatoid arthritis by anti-interleukin-6 monoclonal antibody. J. Rheumatol. 20:1993;259
-
(1993)
J. Rheumatol.
, vol.20
, pp. 259
-
-
Wendling, D.1
Racadot, E.2
Wijdenes, J.3
-
38
-
-
0026598810
-
Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130
-
Yasukawa K., Futatsugi K., Saito T., Yawata H., Narazaki M., Suzuki H., Taga T., Kishimoto T. Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130. Immunol. Lett. 31:1992;123
-
(1992)
Immunol. Lett.
, vol.31
, pp. 123
-
-
Yasukawa, K.1
Futatsugi, K.2
Saito, T.3
Yawata, H.4
Narazaki, M.5
Suzuki, H.6
Taga, T.7
Kishimoto, T.8
|