Association of E-cadherin and β-catenin with metastasis in nasopharyngeal carcinoma

Chinese Medical Journal

Volumn 117, Issue 8, 2004, Pages 1232-1239

  Li, Zhi ^a   Ren, Yi ^b   Lin, Su Xia ^a   Liang, Ying Jie ^a   Liang, Hui Zhen ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

catenin; E cadherin; Invasion and metastasis; Methylation; Mutation; Nasopharyngeal tumor

Indexed keywords

ADENINE; BETA CATENIN; CYTOSINE; GUANINE; MESSENGER RNA; SERINE; THYMINE; UVOMORULIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CELL NUCLEUS; CHINA; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DISEASE ASSOCIATION; DOWN REGULATION; EXON; FEMALE; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; NASOPHARYNX CARCINOMA; NASOPHARYNX TUMOR; PATHOGENESIS; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN METHYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; TUMOR BIOPSY; UNIVERSITY HOSPITAL; WESTERN BLOTTING;

ADULT; AGED; BETA CATENIN; BLOTTING, WESTERN; CADHERINS; CYTOSKELETAL PROTEINS; DNA METHYLATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; NASOPHARYNGEAL NEOPLASMS; NEOPLASM METASTASIS; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATORS;

EID: 4444253496     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Fandi A, Altun M, Azli N, et al. Nasopharyngeal cancer: epidemiology, staging, and treatment. Semin Oncol 1994; 21:382-397.
2. Horikawa T, Yoshizaki T, Sheen TS, et al. Association of latent membrane protein 1 and matrix metalloproteinase 9 with metastasis in nasopharyngeal carcinoma. Cancer 2000; 89: 715-723.
3. Benassi MS, Gamberi G, Magagnoli G, et al. Metalloproteinase expression and prognosis in soft tissue sarcomas. Ann Oncol 2001;12:75-80.
4. Lim SC, Lee MS. Significance of E-cadherin/beta-catenin complex and cyclin D1 in breast cancer. Oncol Rep 2002;9: 915-928.
5. Hoteiya T, Hayashi E, Satomura K, et al. Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo. J Oral Pathol Med 1999; 28:107-111.
6. Garcia del Muro X, Torregrosa A, Munoz J, et al. Prognostic value of the expression of E-cadherin and beta-catenin in bladder cancer. Eur J Cancer 2000;36:357-362.
7. Huiping C, Sigurgeirsdottir JR, Jonasson JG, et al. Chromosome allerations and E-cadherin gene mutations in human lobular breast cancer. Br J Cancer 1999; 81: 1103-1110.
8. Kim HC, Kim HJ, Kim JC. Reduced E-cadherin expression as a cause of distinctive signet-ring cell variant in colorectal carcinoma. J Korean Med Sci 2002;17:23-28.
9. Zheng Z, Pan J, Chu B, Wong YC, et al. Downregulation and abnormal expression of E-cadherin and beta-catenin in nasopharyngeal carcinoma: close association with advanced disease stage and lymph node metastasis. Hum Pathol 1999; 30:458-466.
10. Graff JR, Herman JG, Lapidus RG, et al. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 1995;55:5195-5199.
11. Graff JR, Greenberg VE, Herman JG, et al. Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma. Cancer Res 1998;58:2063-2066.
12. Chang HJ, Jee CD, Kim WH. Mutation and altered expression of beta-catenin during gallbladder carcinogenesis. Am J Surg Pathol 2002;26:758-766.
13. Ewing CM, Ru N, Morton RA, et al. Chromosome 5 suppresses tumorigenicity of PC3 prostate cancer cells: correlation with re-expression of alpha-catenin and restoration of E-cadherin function. Cancer Res 1995;55:4813-4817.
14. Clements WM, Wang J, Sarnaik A, et al. Beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Res 2002;62:3503-3506.
15. Gumbiner BM. Carcinogenesis: a balance between beta-catenin and APC. Curr Biol 1997;7:443-446.
16. Orford K, Crockett C, Jensen JP, et al. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J Biol Chem 1997;272:24735-24738.
17. Rubinfeld B, Albert I, Porfiri E, et al. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 1996;272:1023-1026.
18. Saegusa M, Hashimura M, Yoshida T, et al. Beta-Catenin mutations and aberrant nuclear expression during endometrial tumorigenesis. Br J Cancer 2001;84:209-217.
19. Woo DK, Kim HS, Lee HS, et al. Altered expression and mutation of beta-catenin gene in gastric carcinomas and cell lines. Int J Cancer 2001;95:108-113.
20. Fujimori M, Ikeda S, Shimizu Y, et al. Accumulation of beta-catenin protein and mutations in exon 3 of beta-catenin gene in gastrointestinal carcinoid tumor. Cancer Res 2001;61: 6656-6659.
21. Yanagisawa N, Mikami T, Saegusa M, Okayasu I. More frequent beta-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages. Cancer Res 2001;61:19-22.
22. Joo YE, Rew JS, Choi SK, et al. Expression of e-cadherin and catenins in early gastric cancer. J Clin Gastroenterol 2002;35:35-42.
23. Kallakury BV, Sheehan CE, Winn-Deen E, et al. Decreased expression of catenins (alpha and beta), p120 CTN, and E-cadherin cell adhesion proteins and E-cadherin gene promoter methylation in prostatic adenocarcinomas. Cancer 2001;92: 2786-2795.
24. Garcia-Rostan G, Camp RL, Herrero A, et al. Beta-catenin dysregulation in thyroid neoplasms: down-regulation, aberrant nuclear expression, and CTNNB1 exon 3 mutations are markers for aggressive tumor phenotypes and poor prognosis. Am J Pathol 2001;158:987-996.
25. Herman JG, Graff JR, Myohanen S, et al. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996;93:9821-9826.
26. Tamura G, Yin J, Wang S, et al. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas. J Natl Cancer Inst 2000;92:569-573.
27. El-Bahrawy MA, Poulsom R, Jeffery R, et al. The expression of E-cadherin and catenins in sporadic colorectal carcinoma. Hum Pathol 2001;32:1216-1224.
28. Acs G, Lawton TJ, Rebbeck TR, et al. Differential expression of E-cadherin in lobular and ductal neoplasms of the breast and its biologic and diagnostic implications. Am J Clin Pathol 2001;115:85-98.
29. Chang HW, Chow V, Lam KY, et al. Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance. Cancer 2002;94:386-392.
30. Hasegawa M, Nelson HH, Peters E, et al. Patterns of gene promoter methylation in squamous cell cancer of the head and neck. Oncogene 2002;21:4231-4236.
31. Joo YE, Rew JS, Choi SK, et al. Expression of e-cadherin and catenins in early gastric cancer. J Clin Gastroenterol 2002;35:35-42.
32. Morin P, Spark AB, Rago C, et al. Activation of beta-catenin -Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997;275:1787-1790.
33. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999;398:422-426.
34. Samowitz WS, Powers MD, Spirio LN, et al. Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas. Cancer Res 1999;59:1442-1444.